Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…Further mediation analysis suggested that the intratumoral microbiome may affect the expression of neuron-related genes through bacteria-associated metabolites. …”
Get full text

Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…CTSB further induced ferroptosis via spermidine/spermine-N1-acetyltransferase (SAT1)-mediated lipid peroxidation, mitochondrial damage and mitogen-activated protein kinase (MAPK) signalling pathway activation, eventually affecting the function of HSFs. Moreover, FRA treatment attenuated the formation of HS in rabbit ears via CTSB-mediated ferroptosis. …”
Get full text

Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

“…Contralateral acupuncture (CAT) (Jùcì) is an ancient classic acupuncture technique from Huang Di Nei Jing that refers to the acupoints on the right side (healthy side) selected for diseases on the left (affected side) and vice versa. Some studies have shown that efficacy of CAT on the painful disorder is even better than ipsilateral acupuncture (IAT), but there remains a lack of high-quality evidence to support it.Methods and analysis This is a single-centre, randomised and sham-controlled clinical trial in China with three parallel groups that aim to evaluate the efficacy of CAT in women with unilateral MwoA. 243 participants will be randomly divided into the experimental group (CAT group), control group 1 (IAT group) and control group 2 (sham acupuncture group) (1:1:1 allocation ratio). …”
Get full text

Differential responses of soil C, N, and P ecological stoichiometric characteristics to different configurations of edge-locked forests in the Kubuqi Desert by Xue Chen, Hejun Zuo, Hejun Zuo, Min Yan, Min Yan, Haibing Wang, Haibing Wang, Cheng Xi, Yinchao Chai

“…The vertical distribution patterns of particle size and parameter characteristics had variations. (4) Soil C, N, P, and stoichiometric characteristics are affected by vegetation type, soil depth, and soil texture. …”
Get full text

Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation by Jinru Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Yingying Li, Minglan Yao, Hao Li, Xiaoping Luo, Yan Hao

“…Additionally, IL-6 contributed to ASD by activating JUN/HIF1A pathway, affecting CDKN1A, LYN, and SLC16A3 expression in microglia. …”
Get full text

Seroprevalence of Leptospira spp. antibodies in humans and livestock at various human-animal interfaces in Jordan by Zuhair Bani Ismail, Lea Widemann, Yasmin Daradkeh, Omar Al-Omari, Alaa Fahmawi, Mais Lakaideh, Belal Sha’fout, Haia Mellhem, Leen Al-Bayari, Saad Al-Omari, Hani Talafha, Zaidoun Hijazeen, Bilal Al-Omari, Jean DeMarco, William B. Karesh, Ehab A. Abu-Basha

“…Background and Aim: Leptospirosis, caused by Leptospira spp., affects humans and animals, posing significant health and economic burdens. …”
Get full text

Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course by Elisabetta Zucchi, Elisabetta Zucchi, Federico Banchelli, Cecilia Simonini, Sara De Biasi, Ilaria Martinelli, Giulia Gianferrari, Giulia Gianferrari, Domenico Lo Tartaro, Andrea Cossarizza, Andrea Cossarizza, Roberto D’Amico, Roberto D’Amico, Jessica Mandrioli, Jessica Mandrioli

“…Male sex and cholesterol levels were associated with increasing Tregs (%) over time, while monocytes positively affected Treg concentrations. Treg concentrations showed a modesty association with FVC decline but were not associated with ALSFRS-r decline.DiscussionTreg levels remained stable during the ALS observation period and were not significantly associated with ALSFRS-r variations, suggesting that Treg numbers alone may have limited utility as a pharmaco-dynamic biomarker for ALS trials. …”
Get full text

Cool topoclimates promote cold-adapted plant diversity in temperate mountain forests by Borderieux, Jeremy, De Lombaerde, Emiel, De Pauw, Karen, Sanczuk, Pieter, Vangansbeke, Pieter, Vanneste, Thomas, De Frenne, Pieter, Gégout, Jean-Claude, Serra-Diaz, Josep

“…Understanding how topography and canopies interactively affect understory temperature is key to identifying stable refugia that could shelter cold-adapted forest specialist plants under climate change. …”
Get full text

Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis by Danni Luo, Minyao Zou, Xi Rao, Mingping Wei, Lingzhi Zhang, Yuping Hua, Lingzi Yu, Jiajia Cao, Jinyi Ye, Sichao Qi, Huanan Wang, Yuling Mi, Caiqiao Zhang, Jian Li

“…The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which subsequently affects the mucosal absorptive capacity. However, the underlying mechanisms remain unclear. …”
Get full text

AI-assisted diagnosis of vulvovaginal candidiasis using cascaded neural networks by Zhongxiao Wang, Ruliang Wang, Haichun Guo, Qiannan Zhao, Huijun Ren, Jumin Niu, Ying Wang, Wei Wu, Bingbing Liang, Xin Yi, Xiaolei Zhang, Shiqi Xu, Xianling Dong, Liqun Wang, Qinping Liao

“…ABSTRACT Vulvovaginal candidiasis (VVC) is a prevalent fungal ailment affecting women globally. Timely and accurate diagnosis is crucial. …”
Get full text

Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the infl... by Graziela Vieira Cavalcanti, Fabiola Reis de Oliveira, Rafael Ferraz Bannitz, Natalia Aparecida de Paula, Ana Carolina Fragoso Motta, Eduardo Melani Rocha, John Chiorini, Hilton Marcos Alves Ricz, Denny Marcos Garcia, Maria Cristina Foss-Freitas, Luiz Carlos Conti de Freitas

“…Antimalarial drugs, like CQ, used to treat RAD, may affect the ER function in exocrine glands.…”
Get full text

Lignin Metabolism Is Crucial in the Plant Responses to <i>Tambocerus elongatus</i> (Shen) in <i>Camellia sinensis</i> L. by Wenli Wang, Xiaogui Zhou, Qiang Hu, Qiuhong Wang, Yanjun Zhou, Jingbo Yu, Shibei Ge, Lan Zhang, Huawei Guo, Meijun Tang, Xin Li

“…<i>Tambocerus elongatus</i> (Shen) (Hemiptera: Cicadellidae) is a devastating insect pest species of <i>Camellia sinensis</i>, significantly affecting the yield and quality of tea. Due to growing concerns over the irrational use of insecticides and associated food safety, it is crucial to better understand the innate resistance mechanism of tea trees to <i>T. elongatus</i>. …”
Get full text

Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…Background/Aims Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect the progression of chronic liver disease (CLD) or liver cirrhosis (LC). …”
Get full text

Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression by Yiting Shao, Yu Du, Zheng Chen, Lei Xiang, Shaoqin Tu, Yi Feng, Yuluan Hou, Xiaoxing Kou, Hong Ai

“…However, little is known about adipogenic differentiation alteration in OSCC-derived MSCs (OSCC-MSCs) and how these alterations affect OSCC growth. Methods MSCs were successfully isolated and cultured from normal gingival tissue, OSCC peritumoral tissue, and OSCC tissue. …”
Get full text

Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken by Jinli Tian, Yanxu Wu, Wei Zhao, Guojun Zhang, Hu Zhang, Lin Xue, Lijuan Yang, Tong Zhang, Yaling Gu, Juan Zhang

“…Kyoto Encyclopedia of Genes and Genomes (GSEA-KEGG) analysis identified sphingolipid_metabolism and multiple genes affecting IMF deposition including SPHK1, CERS1, CERS6, GLB1L, SGMS2, UGT8, and UGCG. …”
Get full text

The relationship between impostor phenomenon and emotional exhaustion among Chinese nurses: the mediating role of bi-directional work-family conflict by Yuan Li, Yuan Li, Yuan Li, Fangxinrui Qiu, Biru Luo, Biru Luo, Yanling Hu, Yanling Hu, Yanling Hu, Jie Li, Ying Xin Li, Ying Xin Li, Ying Xin Li, Ping He, Jinbo Fang

“…CI represents the confidence interval for the specified parameter).ConclusionThis study reveals that impostor phenomenon not only directly affects emotional exhaustion but also exerts parallel mediation effects through bi-directional work–family conflict, with work interfering with family exerting a stronger mediating effect than family interfering with work. …”
Get full text

Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…Objectives Thromboembolic events are the major factor affecting the prognosis of patients with chronic kidney disease (CKD). …”
Get full text

Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…IntroductionIdiopathic pulmonary fibrosis (IPF) is a rare but debilitating lung disease characterized by excessive fibrotic tissue accumulation, primarily affecting individuals over 50 years of age. Early diagnosis is challenging, and without intervention, the prognosis remains poor. …”
Get full text

Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…IntroductionAmyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons, resulting in muscle atrophy, spasticity, hyperreflexia, and paralysis. …”
Get full text

Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model by Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Luca Boldrini, Agnese Latorre, Deniz Can Guven, Serena Iacovelli, Tiziana Talienti, Alessandro Rizzo, Francesco Alfredo Zito, Raffaella Massafra

“…Conclusion Finally, the changes in DCE‐MRI at pre‐ and mid‐treatment could affect the accuracy of pCR prediction to NAC.…”
Get full text