Predicting the Global Distribution of <i>Nitraria</i> L. Under Climate Change Based on Optimized MaxEnt Modeling by Ke Lu, Mili Liu, Qi Feng, Wei Liu, Meng Zhu, Yizhong Duan

“…UV-B seasonality (UVB-2), UV-B of the lowest month (UVB-4), precipitation of the warmest quarter (bio18), the DEM (Digital Elevation Model), and annual precipitation (bio12) were the key variables affecting the distribution area of <i>Nitraria</i> L, with contributions of 54.4%, 11.1%, 8.3%, 7.4%, and 4.1%, respectively. …”
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Simultaneous Debridement and Titanium Mesh Reconstruction in Patients with Compound Depressed Skull Fracture: A Retrospective Descriptive Study by Srikant Das, Acharya Suryakant Pattajoshi, Mahesh Kumar Kusta, Dibakar Sarkar

“…The predominant mechanism of injury was Road Traffic Accident (RTA), affecting 59 (60.2%) patients. The frequency of skull fractures was significantly higher in men 91 (92.8%) patients compared to women 7 (7.2%) patients. …”
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The Global Burden of Polycystic Ovary Syndrome in Women of Reproductive Age: Findings from the GBD 2019 Study by Jiang B

“…Countries such as Italy, Japan, New Zealand, and Australia had the highest burdens, while Central and Eastern Europe had the lowest. The age group most affected was women aged 20– 29 years, emphasizing the necessity for targeted interventions.Keywords: reproductive age, polycystic ovary syndrome, incidence, disability-adjusted life-years, socio-demographic index…”
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Assessment of Knowledge, Attitude and Practices of Health Workers Towards Hepatitis B Virus Infection Prevention in Health Centers of Bushenyi District. by Byamukama, Julius

“…This indicates that there is a need to alleviate the gaps as these might affect behaviors in seeking medical attention. In conclusion, my study found that health workers are at a very high risk of contracting HBV infection during their training owing to the low HBV vaccine uptake rate and high rate of accidental exposure to blood. …”
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Community Work Participation and Outcomes in Nyagatare District, Rwanda. by Jean Marie Vianney, Ruzindana

“…The study examined the factors affecting people’s participation in community work and outcomes in Nyagatare District, Rwanda. …”
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Prevalence, management, and outcomes of haemorrhagic events in left ventricular assist device recipients by Laetitia Pourtau, Maxime Beneyto, Jean Porterie, Jerome Roncalli, Montse Massot, Caroline Biendel, Pauline Fournier, Romain Itier, Michel Galinier, Olivier Lairez, Clement Delmas

“…However, LVADs are associated with various complications, including bleedings, which affect the prognosis. The aim of the study was to explore the prevalence, management, and outcomes of haemorrhagic adverse events in LVAD recipients. …”
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Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

“…We projected the incidence and mortality of CRC, cost, and quality-adjusted life years for 2023–2038; and performed incremental cost-effectiveness, probability acceptability, and sensitivity analyses to identify the optimal scheme and the factors affecting this choice. Results By 2038, all standard colonoscopy, colonoscopy following fecal immunochemical testing, and risk-tailored schemes were effective in reshaping China’s colorectal cancer trajectory, with relative reductions in colorectal cancer incidence and mortality rates of up to 34% and 33.7%, respectively, versus no screening. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…We also discovered that CDK8/CDK19 affect splicing, a novel means by which Mediator kinases control gene expression. …”
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Effectiveness and Safety of Treatments for Early‐Stage Merkel Cell Carcinoma: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies by Yves Paul Vincent Mbous, Rowida Mohamed, Usha Sambamoorthi, Murtuza Bharmal, Khalid M. Kamal, Traci LeMasters, Joanna Kolodney, George A. Kelley

“…Conclusions Although adjuvant RTx improves survival and recurrence outcomes among early‐stage MCC, the safety and effectiveness of standard therapies in MCC remains poorly studied and, thus, affects the synthesis of evidence across important patient and clinical characteristics. …”
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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

“…There has been, and continues to be, much discussion around the functional consequences of this Y402H polymorphism, whether the soluble FH protein confers its risk association, or if the cells expressing the protein themselves are affected by the genetic alteration. In our study, we examined the cell characteristics of the retinal pigment epithelium (RPE) cells, which play a major role in retinal homeostasis and stability and which are synonymously linked to AMD.MethodsHere, we employ RPE cells derived from induced pluripotent stem cells (iPSC) generated from donors, carrying either homozygous 402Y (low risk) or 402H (high risk) variants of the CFH gene. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…(His175Tyr) missense variant could modify the interaction between connexins and the connexon assembly, affecting the homotypic GJD3 gap junction between cells. …”
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Preconditioning of Rat Bone Marrow-Derived Mesenchymal Stromal Cells with Toll-Like Receptor Agonists by Fabiana Evaristo-Mendonça, Gabriela Sardella-Silva, Tais Hanae Kasai-Brunswick, Raquel Maria Pereira Campos, Pablo Domizi, Marcelo Felippe Santiago, Ricardo Augusto de Melo Reis, Rosalia Mendez-Otero, Victor Túlio Ribeiro-Resende, Pedro Moreno Pimentel-Coelho

“…LPS or Poly(I:C) stimulation did not affect the viability or the morphology of rBM-MSCs and did not modify the expression pattern of key cell surface markers. …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

“…With a presumption that the early coagulation phase may affect the occurrence of NAION, this study aims to investigate the early coagulation markers, E-selectin and P-selectin, to determine whether these biomolecular changes play a significant role in NAION, thus potentially leading to a better clinical approach. …”
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Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts by Yanping Lin, Yanping Lin, Rui Zhao, Rui Zhao, Jiachun Huang, Tongying Chen, Tongying Chen, Haolin Yang, Haolin Yang, Haiwei Guo, Lei Wan, Zhihai Zhang, Ying Li, Genfu Zhu, Hongxing Huang, Hongxing Huang

“…BackgroundThe Beclin-1/Bcl-2 complex plays a pivotal role in regulating both autophagy and apoptosis in osteoblasts affected by osteoporosis. This study first investigates whether the Bushen Jianpi Huoxue Formula can enhance the cellular function of osteoblasts. …”
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Readiness of adults with type 1 diabetes and diabetes caregivers for diabetes distress monitoring using a voice-based digital health solution: insights from the PsyVoice mixed meth... by Carine de Beaufort, Guy Fagherazzi, Aurélie Fischer, Till Seuring, Franchesca Aguirre Vergara, Gloria A Aguayo, India Pinker, Maria A Tichomirowa, Siri-Maria Kamp

“…Objectives Diabetes distress can negatively affect the well-being of individuals with type 1 diabetes (T1D). …”
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Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries by Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente, Bjorn Gudbjornsson, Olafur Palsson, Vappu Rantalaiho, Ritva Peltomaa, Catalin Codreanu, Corina Mogosan, Florenzo Iannone, Marco Sebastiani, Gareth T. Jones, Gary J. Macfarlane, Isabel Castrejon, Ziga Rotar, Brigitte Michelsen, Johan K. Wallman, Irene van der Horst-Bruinsma, Oliver Distler, Mikkel Østergaard, Merete Lund Hetland, Raphael Micheroli, Caroline Ospelt

“…Conclusion The time to resolution of joint swelling upon treatment with TNFi in patients with PsA seems to depend on the localisation of the affected joints.…”
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Microgeographical Variation in <i>Dirofilaria immitis</i> Prevalence in Dogs in Suburban and Urban Areas of Rio De Janeiro, Brazil by Marianna Laura Elis Chocobar, Elizabeth Moreira dos Santos Schmidt, Ângelo Joel Ferreira Mendes, Paul Christopher Duncan Johnson, William Weir, Rossella Panarese

“…Dirofilariosis, a mosquito-borne disease caused by <i>Dirofilaria immitis</i> and <i>Dirofilaria repens</i>, affects canids, felids and occasionally humans. Recent evidence suggests that <i>D. immitis</i> prevalence is rising in the canine populations in several areas of Brazil, even those historically considered to be non-endemic, highlighting the need for ongoing surveillance. …”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Mean (± SD) follow-up period was 4.7 (± 2.8) years.ResultsThe overall prevalence of TA among our T1D children was 22.8% ([20.3;25.5], 310 cases) with significantly more girls affected (p&lt;0.001). From 2013 to 2022, TA prevalence rose from 15.9% to 20.6% (p=0.041). …”
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How do leaf functional traits influence above-ground tree carbon in tropical hill forests of Bangladesh? by Ariful Khan, Md Rezaul Karim, Mohammed A.S. Arfin-Khan, Md. Shamim Reza Saimun, Fahmida Sultana, Sharif A. Mukul

“…However, in RKWS, only CWM-leaf width (R2 = 0.015, P < 0.01) significantly affected AGTC, while other CWM-leaf traits showed no significant impact. …”
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Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer by Sung Uk Bae, Hye Won Lee, Jee Young Park, Incheol Seo, Jae-Min Cho, Jin Young Kim, Ju Yup Lee, Yoo Jin Lee, Seong Kyu Baek, Nam Kyu Kim, Sang Jun Byun, Shin Kim

“…Similarly, radiation increased PD-L1 in radioresistant DLD-1 cells more than in radiosensitive HCT116 cells, also affecting PD-L1-regulating genes and immune checkpoints in CRC cells. …”
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