Human–nature connectedness and sustainability across lifetimes: A comparative cross‐sectional study in France and Colombia by Gladys Barragan‐Jason, Maxime Cauchoix, Paula A. Diaz‐Valencia, Arielle Syssau‐Vaccarella, Solène Hemet, Camilo Cardozo, Suzanne M. Skevington, Philipp Heeb, Camille Parmesan

“…Human–nature connectedness is linked to improved human welfare and actions for nature conservation and can be increased by direct contact with natural environments in adults living in the Global North. It has not been shown whether these relations are true across lifetimes and in the Global South, making it difficult to generalise about the effects of human–nature connectedness globally. …”
Get full text

Atopic Dermatitis Treatments Before and After Initiation of Ruxolitinib Cream: 6-Month Follow-Up Analysis of a US Payer Claims Database by Liu J, Desai K, Teng CC, Sturm D, Stockbower G, Patadia H, Willey V

“…This analysis describes treatment patterns before and after initiation of ruxolitinib cream among patients with AD.Patients and Methods: This retrospective, observational study used medical and pharmacy claims data from the Healthcare Integrated Research Database (HIRD®) and included adults and adolescents (aged ≥ 12 years) with an AD diagnosis, a first claim for ruxolitinib cream (index date) between October 2021 and July 2022, and continuous enrollment in a commercial or managed Medicare plan for 6 months before and after the index date. …”
Get full text

Protocol publication rate and comparison between article, registry and protocol in RCTs by Sylvain Mathieu, Jean-Baptiste Bouillon-Minois, Laurent Renard Triché, Emmanuel Coudeyre, De Chazeron Ingrid, Finotto Thomas, Catherine Laporte, Xavier Moisset, Ludovic Samalin, Guillaume Villatte, Bruno Pereira, Methodology And Evidence Statistics for Transparency in medical Research and Outcome reporting (MAESTRO) working group

Get full text

Hospital in-reach family-centred social prescribing pilot for children with neurodisability: mixed methods evaluation with social return on investment analysis by Laura Gordon, Megan Hastry, Angela Bate, Katie Gordon, Emily Greaves, Simoni Dimitriadou, Tim Rapley, Anna Purna Basu

“…Most schemes are community-based, targetting adults. Vulnerable populations including hospitalized children with neurodisability and their families, could also benefit from social prescribing. …”
Get full text

Imaging and Clinical Characteristics of 8 Cases of COVID-19 Complicated with Pneumomediastinum in Children by FU Qiang, REN Zuolei, LIN Zhiqiang, GONG Jianfeng, WANG Changzheng, WANG Ting, HU Yalan, TAN Jufang

“…Background The imaging of COVID-19 (COVID-19) in children is different from that of adults, mainly manifested as subpleural ground glass shadows, patchy high-density shadow, and solid shadow, and rarely complicated with pneumomediastinum. …”
Get full text

Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients by Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Mitsuhiro Kitani, Kazuhiro Kawano, Yoshio Taketani, Masataka Sata

Get full text

Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions by Soumilee Chaudhuri, Minyoung Cho, Julia C. Stumpff, Paula J. Bice, Özkan İş, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho

“…We conducted an in-depth literature search using Medline and Covidence to identify pertinent AD studies that utilized single-cell technologies in human post-mortem brain tissue by focusing on understanding the transcriptional differences in cerebrovascular cell types and subtypes in AD and cognitively normal older adults. We also discuss impaired cellular crosstalk between vascular cells and neuroglial units, as well as astrocytes in AD. …”
Get full text

A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…Comparison of two oral dipeptidyl peptidase (DPP)-4 inhibitors, sitagliptin and linagliptin, for type 2 diabetes mellitus (T2DM) treatment was used as an example.Design Systematic review with MBMA.Data sources MEDLINE, EMBASE, http://www.ClinicalTrials.gov, Cochrane review of DPP-4 inhibitors for T2DM, sitagliptin trials on Food and Drug Administration website to December 2011 and linagliptin data from the manufacturer.Eligibility criteria for selecting studies Double-blind, randomised controlled clinical trials, ≥12 weeks’ duration, that analysed sitagliptin or linagliptin efficacies as changes in glycated haemoglobin (HbA1c) levels, in adults with T2DM and HbA1c >7%, irrespective of background medication.Model development and application A Bayesian model was fitted (Markov Chain Monte Carlo method). …”
Get full text

Extended Reality Interventions for Health and Procedural Anxiety: Panoramic Meta-Analysis Based on Overviews of Reviews by Tom Arthur, GJ Melendez-Torres, David Harris, Sophie Robinson, Mark Wilson, Sam Vine

“…For procedural anxieties, effects may be influenced by publication bias and appear more pronounced for children (vs adults) and nonimmersive (vs immersive) technology interventions, but they were not different by indication. …”
Get full text

The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Methods Conducted in a hospital serving a socioeconomically deprived population, this study included all adults hospitalised with COVID-19 from 1st November 2023 to 31st August 2024. …”
Get full text

Impact of heavy metal pollution on the use of fishing pond land, a former site of used battery smelting by E. Riani, N.A. Butet, M. Ansori, M.R. Cordova

“…Goldfish from this area are contaminated with high levels of heavy metals and are unfortunately unsafe for consumption because zinc is perilous. Adults are only allowed 3 grams per week, while children may not consume goldfish from this fishing pond. …”
Get full text

Impact of Comorbidities on Prognosis and Treatment Outcomes in Elderly Patients with Hodgkin Lymphoma by Dávid Tóthfalusi, Boglárka Dobó, Fanni Borics, László Imre Pinczés, Árpád Illés, Zsófia Miltényi

“…<b>Background/Objectives</b>: Hodgkin lymphoma (HL) primarily affects young adults, but about 20% of cases occur in patients over the age of 60 years. …”
Get full text

Owners’ perceptions of dog treat management in Western Romania by Sorana Daina, Anamaria Blaga-Petrean, Silvana Popescu, Ioana Delia Pop, Daniel Mierlita, Adrian Macri

“…The wide range and availability of these products often pair with the fondness of owners for their companions, leading to overfeeding them with rewards.MethodsThis study explored owner treat provision behaviors among 890 voluntarily participating dog owners in Western Romania through an online survey conducted between June and November 2023.ResultsThe majority of respondents were women (72%) and younger adults aged 18–24 (39%). Emotional attachment was the primary motivation for providing treats (52%), followed by perceived health benefits (35%) and training purposes (25%). …”
Get full text

Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype by Niloufar Rasaei, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Mahsa Samadi, Mohammad Keshavarz Mohammadian, Elnaz Daneshzad, Khadijeh Mirzaei

“…Therefore, in this study, we investigated how dietary fat quality indices with metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUO) based on the Karelis criterion interact with genetic susceptibility in Iranian female adults. Methods In the current cross-sectional study, 279 women with overweight or obesity participated. …”
Get full text

Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
Get full text

Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…We investigated whether common genetic risk factors in IPF are associated with developing lung parenchymal abnormalities following severe COVID-19 disease.Methods Consecutive adults hospitalised for laboratory-confirmed COVID-19 infection were prospectively recruited from March to May 2020. …”
Get full text

Prevalence of hearing loss and factors associated with hearing loss in Ethiopia: findings from the 2023 National Ethiopia Hearing Survey by Tolesa Diriba Biratu, Alene Meshesha, Uta Fröschl, Michael Kebede, Yoseph Worku, Fufa Hunduma

“…The prevalence was 8.1% among children aged 5–14 years and 73.7% among adults aged 60+ years. Factors significantly associated with hearing loss included being over 60 years old (adjusted OR (AOR)=51.41; 95% CI 36.95, 71.53), having no formal education (AOR=2.12; 95% CI 1.47, 3.08), ear discharge (AOR=3.01; 95% CI 2.07, 4.38), wax presence (AOR=1.92; 95% CI 1.53, 2.40), and tympanic membrane abnormality (AOR=17.17; 95% CI 12.27, 24.02). …”
Get full text

Short Term Outcome of High Dose Dexamethasone Versus Prednisone In Children With Acute Immune Thrombocytopenic Purpura: A Single Center Trial by Ahmed Osama Kaddah, Niveen Salama, Doaa Maged Ahmed, Mariam Saad Nassim

“…While high dose dexamethasone (HD-DXM) can be used as a first line therapy in adults, data about its use in children is scarce. …”
Get full text

Association between various blood glucose variability-related indicators during early ICU admission and 28-day mortality in non-diabetic patients with sepsis by Jingyan Zhou, Zhiheng Chen, Hao-Neng Huang, Chun-Quan Ou, Xin Li

“…Methods The single-center retrospective cohort study included 7,049 non-diabetic adults with sepsis who had at least 3 records of bedside capillary point of care BG testing during the first day after ICU admission from MIMIC-IV database (2008 to 2019). …”
Get full text

Temptation at every corner: exploring public perceptions of food cues and policy support for governmental food cue regulation in outdoor public spaces by Tamika M. Wopereis, Sanne K. Djojosoeparto, Frédérique C. Rongen, Sanne C. Peeters, Emely de Vet, Maartje P. Poelman

“…Methods An exploratory study was conducted among 101 adults who photographed outdoor visual food cues in their municipality and answered survey questions about the food cues using a bespoke app (‘myfoodenvironment’). …”
Get full text