Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice by Daisuke Katagiri, Shinya Nagasaka, Keiko Takahashi, Suwan Wang, Ambra Pozzi, Roy Zent, Akira Shimizu, Ming-Zhi Zhang, Joachim R. Göthert, Toin H. van Kuppevelt, Raymond C. Harris, Takamune Takahashi

“…NO donor suppressed NFAT2 expression and activation in high-glucose cultured podocytes as well as in diabetic E-eNOSKO mice. …”
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Influence of Floral Strip Width on Spider and Carabid Beetle Communities in Maize Fields by Jia-Lu Li, Lan-Mei Huang, Zi-Yi Xiang, Jian-Ning Zhao, Dian-Lin Yang, Hui Wang, Yan-Jun Zhang

“…Carabid beetle activity density varied considerably with strip width and proximity to the edge, typically peaking at the edges of wider strips. …”
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Ring finger protein 5 mediates STING degradation through ubiquitinating K135 and K155 in a teleost fish by Xiaowei Qin, Chuanrui Li, Mincong Liang, Zhen Qian, Yanlin You, Shaoping Weng, Jianguo He, Jianguo He, Changjun Guo, Changjun Guo

“…Stimulator of interferon genes (STING) is a key connector protein in interferon (IFN) signaling, crucial for IFN induction during the activation of antiviral innate immunity. In mammals, ring finger protein 5 (RNF5) functions as an E3 ubiquitin ligase, mediating STING regulation through K150 ubiquitylation to prevent excessive IFN production. …”
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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M by Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards

“…The IL-6-type cytokine Oncostatin M (OSM) elevates lung inflammation, Th2-skewed cytokines, alternatively activated (M2) macrophages, and eosinophils in C57Bl/6 mice in vivo. …”
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Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway by Jian-Hong Lin, Huan-Hsin Chang, Wen-Sen Lee, Pei-Ching Ting, Yu-Po Luo, Kun-Ta Yang

“…Our data suggest that PAME activated the GPR40/120/PLC-mediated pathway, which in turn increased the intracellular Ca2+ levels, thereby activating the ERK, and eventually enhanced adipogenic differentiation in rAD-MSCs. …”
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Quantitative profiling and mechanisms exploration of Epimedium total flavonoid capsules in neuroinflammation: An integrated study of pharmacokinetics, network pharmacology, and mol... by Xiaochun Zeng, Junran Shao, Dabo Pan, Siying Zeng, Zhenzhong Wang, Xinsheng Yao, Haibo Li, Wei Xiao, Yang Yu

“…The LPS-induced BV-2 cell model confirmed ETFCs′ constituents showed inhibitory activities on pro-inflammatory cytokine secretion, mRNA expressions of IL-6, TNF-α, COX-2, iNOS and could down-regulate the protein expressions of COX-2 and iNOS. …”
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Multicentre study conducted across centres in the USA, Europe and Australia to assess the safety and effectiveness of a bilateral hypoglossal nerve stimulation system for the treat... by B Tucker Woodson, Maria V Suurna, M Boyd Gillespie, Tod C Huntley, Melyssa Hancock, Angela Santos, Jeyakumar Subbaroyan, Fatima Makori, Grégoire Fesneau, Clemens Heiser, David T Kent

“…Bilateral hypoglossal nerve stimulation (HNSBL) is a new treatment for managing OSA, and this study is intended to determine whether an HNSBL system is a safe and effective treatment option for adults with OSA.Methods and analysis This is a pivotal, multicentre, prospective, single-arm study of HNSBL in PAP-intolerant adults with moderate to severe OSA. The device is activated 2 months after implantation with stimulation settings optimised before the final 12-month sleep study. …”
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Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…Conclusion The systematic review will comprise the knowledge of the existing literature with regards to the effects of the physical activity interventions compared to an active or inactive control group. …”
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Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease by Beth Whittington, Evangelos Tzolos, Shruti Joshi, Rong Bing, Jack Andrews, Krithika Loganath, Neil Craig, Craig Balmforth, Laura Clark, Christophe Lucatelli, Mark G MacAskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Marc R. Dweck, Michelle C. Williams, William Whiteley, Edwin J. R. van Beek, Joanna M. Wardlaw, David E. Newby

“…Abstract 18F-GP1 is a novel highly specific radiotracer that binds to activated platelets and thrombus. We aimed to establish the observer repeatability of coronary, carotid and cerebral 18F-GP1 uptake in patients presenting with acute myocardial infarction or ischaemic stroke. …”
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Bacterial and Viral-Induced Changes in the Reflectance Spectra of <i>Nicotiana benthamiana</i> Plants by Alyona Grishina, Maxim Lysov, Maria Ageyeva, Victoria Diakova, Oksana Sherstneva, Anna Brilkina, Vladimir Vodeneev

“…<i>P. syringae</i> caused severe inhibition of photosynthetic activity in the infected leaf, while PVX did not have a pronounced effect on photosynthetic activity. …”
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NMR Studies on the Structure of Yeast Sis1 and the Dynamics of Its Interaction with Ssa1-EEVD by Carolina O. Matos, Glaucia M. S. Pinheiro, Icaro P. Caruso, Gisele C. Amorim, Fabio C. L. Almeida, Carlos H. I. Ramos

“…While both classes stimulate the ATPase activity of Ssa1 (yeast HSP70) through the J-domain, only class B JDPs possess the unique ability to efficiently stimulate Ssa1 in disaggregation processes. …”
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Molecular mechanisms underlying sexual precocity in Chinese mitten crab (Eriocheir sinensis): aldh1a1 regulates retinol metabolism via miRNAs in the hepatopancreas by Xiaoyan Jia, Weibo Jiang, Ronghua Zhou, Wei Qiang, Xuejiao Lv, Le Chang, Qiyong Qiu, Wenbin Liu, Dingdong Zhang

“…In short, NW_020868524.1_2213 in the hepatopancreas could activate the retinol metabolic pathway via aldh1a1, thus regulating precocious and gonadal development in E. sinensis. …”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…ALK, FAK, and downstream target activation were rapidly decreased upon ESK440 treatment, and this was associated with impaired cellular migration and invasion. …”
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Comprehensive spatial mapping of metals and metalloids in the Peruvian Mantaro Valley using advanced geospatial data Integration by Samuel Pizarro, Narcisa G. Pricope, Jesús Vera, Juancarlos Cruz, Sphyros Lastra, Richard Solórzano-Acosta, Patricia Verástegui Martínez

“…Soil formation and the distribution of metals are shaped by various factors such as geology, climate, topography, and human activities, making accurate modeling highly challenging. …”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Our study suggests that apatinib, sintilimab combined with carboplatin and nab-paclitaxel chemotherapy showed a promising clinical activity and manageable safety profile in early TNBC and merits further study. …”
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Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis by Xiaohui Meng, Xiaohui Meng, Li Sheng, Yongqing You, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Funing Wang, Ziren Zhou, Ziren Zhou, Yun Shan, Meixiao Sheng

“…Qixue Huazheng formula (QXHZF), comprising Astragalus membranaceus, Centella asiatica, and Ligusticum sinense, is applied to treat PD-related peritoneum injury related; however, the active components, core genes, and underlying mechanism involved remain unclear.MethodsThe anti-PF effects of QXHZF were verified in vivo and in vitro. …”
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Antioxidant response of Calendula officinalis L. assisted synthesized zinc oxide nanoparticles by Ajay Kumar Tiwari, Saket Jha, Sharad Kumar Tripathi, Ram Raseele Awasthi, Abhishek Kumar Bhardwaj, Abhimanyu Kumar Singh, Anupam Dikshit

“…Further synthesized material was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay to evaluate its antioxidant activity. It showed that ZnO NPs exhibited significant antioxidant activity through scavenging DPPH free radicals. …”
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Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features by Han Jin, Shengwen Yang, Hao Huang, Sijing Cheng, Pengkang He, Sixian Weng, Min Gu, Hongxia Niu, Wei Hua, Yiran Hu, Hui Li

“…The RAP+LBBB group exhibited a prolonged overall ventricular activation time, delayed left ventricular activation, and lesser impact on the right ventricle. …”
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Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

“…Results: Patients with CLD showed CRSD-like phenotypes including increased night activity and early awakening, which were strongly correlated with increased BA levels (ie, cholemia). …”
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Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2 by Fan Sun, Pengrong Yan, Yadong Xiao, Hongqiao Zhang, Steven D Shapiro, Gutian Xiao, Zhaoxia Qu

“…NanoPDLIM2 showed low toxicity, high tumor specificity, antitumor activity, and greatly improved the efficacy of anti-PD-1 and chemotherapeutic drugs, with complete tumor remission in most mice and substantial tumor reduction in the remaining mice by their triple combination. …”
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