Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…The molecular dynamic simulations of Adenosine 5’-phosphosulfate kinase in P. chrysogenum, UDP-N-acetylglucosamine in A. flavus, and FDC1 in A. niger with 10b also demonstrated the formation of stable complexes with favorable values of Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), Solvent Accessible Surface Area (SASA), and Radius of Gyration (Rg). …”
Get full text

The Impact of the COVID-19 Pandemic on Oldest-Old Social Capital and Health and the Role of Digital Inequalities: Longitudinal Cohort Study by Luca Guido Valla, Michele Rossi, Alessandra Gaia, Antonio Guaita, Elena Rolandi

“… BackgroundDuring the COVID-19 pandemic, information and communication technology (ICT) became crucial for staying connected with loved ones and accessing health services. In this scenario, disparities in ICT use may have exacerbated other forms of inequality, especially among older adults who were less familiar with technology and more vulnerable to severe COVID-19 health consequences. …”
Get full text

Digital Mindfulness Training for Burnout Reduction in Physicians: Clinician-Driven Approach by Lia Antico, Judson Brewer

“…In the first study, 27 physicians received the digital MT in a podcast format, while in the second study, 29 physicians and nurse practitioners accessed the same training through a free app-based platform. …”
Get full text

Electronic Health Record Data Collection Practices to Advance Standardization and Interoperability of Patient Preferences for Interpretation Services: Qualitative Study by Krysta Heaney-Huls, Rida Shams, Ruth Nwefo, Rachel Kane, Janna Gordon, Alison M Laffan, Scott Stare, Prashila Dullabh

“…Standardized collection and exchange of patient interpretation needs can improve access to appropriate language assistance services. …”
Get full text

Mechanism of abnormal specification of spermatogonial stem cells after Rb1 knockout in mitotic-arrested prospermatogonia by CHEN Xinling, CHEN Xinling, LONG Yixuan, DU Guihua, DU Guihua

“…Methods‍　‍① R language was used to analyze the single-cell RNA sequencing （scRNA-seq） data of prospermatogonia derived from postnatal day 0.5 （P0.5） male mice through the gene expression omnibus （GEO） public database （accession number： GSE124904）. ② Mitoti-arrested prospermatogonia Rb1 conditional knockout （cKO） mice as well as Rb1 cKO mice with Id4-gfp transgene were generated using Vasa-Cre mice crossed with Rb1flox/flox or Id4-gfpTg；Rb1flox/flox mice. …”
Get full text

Time-dynamic associations between symptom-related expectations, self-management experiences and somatic symptom severity in everyday life: an ecological momentary assessment study... by Bernd Löwe, Yvonne Nestoriuc, Anne Toussaint, Stefanie Hahn, Franz Pauls, Simon Kirchhof

“…Multilevel mixed-effects linear regression analyses were conducted for data analysis.Setting Data was collected in real-time from university students via smartphones, with three predetermined assessments per day over seven consecutive days.Participants A total of 104 students (63.5% male, 0% diverse) who were 18 years or older, possessing sufficient German language skills and had access to an Android-powered smartphone were included.Interventions Participants were randomised to one of two different expectation framing groups, either receiving questionnaires for the expected impairment due to somatic symptoms (negative framing) or for the expected freedom from impairment due to somatic symptoms (positive framing).Primary outcome measures Somatic symptom severity was assessed using an adapted version of the Patient Health Questionnaire, with 11-point instead of 3-point Likert-scales. …”
Get full text

Improving Mental Health and Well-Being Through the Paradym App: Quantitative Study of Real-World Data by Athina Marina Metaxa, Shaun Liverpool, Mia Eisenstadt, John Pollard, Courtney Carlsson

“… BackgroundWith growing evidence suggesting that levels of emotional well-being have been decreasing globally over the past few years, demand for easily accessible, convenient, and affordable well-being and mental health support has increased. …”
Get full text

Design of Intelligent Feature Selection Technique for Phishing Detection by Sharvari Sagar Patil, Narendra M. Shekokar, Sridhar Chandramohan Iyer

“… Phishing attacks lead to significant threats to individuals and organizations by gaining unauthorized access. The attackers redirect the users to fake websites and steal their credentials and other confidential data. …”
Get full text

The gene Sr38 for bread wheat breeding in Western Siberia by E. S. Skolotneva, V. N. Kelbin, V. P. Shamanin, N. I. Boyko, V. A. Aparina, E. A. Salina

“…A collection of hybrid lines and varieties of bread spring wheat adapted to West Siberia (Omsk SAU) was analyzed to identify accessions promising for the region. The presence of the gene was postulated by genotyping with specific primers (VENTRIUP-LN2) and phytopathological tests with avirulent clones of the fungus. …”
Get full text

The rat's sciatic nerve functional index dynamics after its transection and recovery by means of epineural neurorrhaphy by Ziia K. Melikov, Volodymyr V. Medvediev

“…In animals of the Sham group (n=24) an access to the sciatic nerve was performed, in animals of the Sect group (n=29) — the sciatic nerve was transected, and Raph group (n=23) — transection and immediate epineural suturing of the sciatic nerve was performed. …”
Get full text

Peer- and community-led responses to HIV: A scoping review. by George Ayala, Laurel Sprague, L Leigh-Ann van der Merwe, Ruth Morgan Thomas, Judy Chang, Sonya Arreola, Sara L M Davis, Aditia Taslim, Keith Mienies, Alessandra Nilo, Lillian Mworeko, Felicita Hikuam, Carlos Garcia de Leon Moreno, José Antonio Izazola-Licea

“…Ten studies reported improvements in HIV service access, quality, linkage, utilization, and retention resulting from peer- or community-led programs or initiatives. …”
Get full text

Inequalities in total fertility rate in Sierra Leone, 2008–2019 by Augustus Osborne, Umaru Sesay, Mohamed S. Bah, Camilla Bangura, Bright Opoku Ahinkorah

“…While the decreasing educational inequality is encouraging, the continued disadvantage faced by women with no education indicates a need for enhanced educational access and adult literacy programs. The provincial disparities between Western and Eastern provinces point to a need for balanced provincial development policies and improved resource distribution, particularly in the Eastern province, where women face greater disadvantages. …”
Get full text

Provincial distribution and predictors of desire for more children among married and cohabiting women in Sierra Leone by Augustus Osborne

“…The association between contraceptive use and lower fertility desires underscores the role of access to and education about contraception in shaping family planning decisions. …”
Get full text

A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial by Ryan J Marker, Andrew J Kittelson, Jared J Scorsone, Ian A Moran, John C Quindry, Heather J Leach

“…Rural survivors of cancer, however, report specific barriers to engaging in exercise programs and lack overall access to effective programs. ObjectiveThe purpose of this investigation was to assess the feasibility of a novel telehealth exercise program designed specifically for rural survivors of cancer with CRF. …”
Get full text

Factors and Reasons Associated with Hesitating to Seek Care for Migraine: Results of the OVERCOME (US) Study by Robert E. Shapiro, Eva Jolanda Muenzel, Robert A. Nicholson, Anthony J. Zagar, Michael L. Reed, Dawn C. Buse, Susan Hutchinson, Sait Ashina, Eric M. Pearlman, Richard B. Lipton

“…The main limitation of the study includes the requirement for respondents to have internet, access which may have reflected cohort bias, and the quota sampling rather than random sampling to create a demographically representative sample. …”
Get full text

Rozwój usług bibliotecznych w czasach kryzysu. (przeł. Tomasz Olszewski) by Paul Ayris

“…W artykule podano dwa konkretne przykłady takiego rozwiązania: pierwszy, który jest już znany i zyskał dobrą opinię – portal DART-Europe udostępniający prace doktorskie i dyplomowe w formie elektronicznej na zasadach open access; drugi, który znajduje się dopiero w fazie wstępnych dyskusji i planowania – rozwiązanie oparte na chmurze obliczeniowej dla prawdziwie zespołowego katalogowania z udziałem brytyjskich bibliotek naukowych i narodowych. …”
Get full text

Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities by Beng Heng Ang, Sujatha Das Gollapalli, Mingzhe Du, See-Kiong Ng

“…MethodsWe curated a dataset of 29,329 posts from widely accessed OMHCs, labeling each with relevant schemas and mental health problems. …”
Get full text

Evaluation of Metabolic Characteristics of Brain Tumours Utilising 31-Phosphorus MR Spectroscopy in 3T MRI: A Cross-sectional Study by Nivetha Kannan, Babu Peter Sathyanathan

“…MR spectroscopy, a non invasive technique has provided access to the novel field of metabolomics in-vivo. …”
Get full text

Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the... by Christina Reuther, Louise von Essen, Mudassir Imran Mustafa, Markus Saarijärvi, Joanne Woodford

“…Digital interventions, such as internet-administered cognitive behavioral therapy, offer an accessible and flexible means to support parents. However, engagement with and adherence to digital interventions remain a significant challenge, potentially limiting efficacy. …”
Get full text

Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study by Zijie Wang, Zhitao Gong, Jianshang Wen, Shanyu Zhang, Xiao Hu, Wenliang Guo, Yanghua Tian, Qi Li

“…Noninvasive indices of liver fibrosis may serve as an easily accessible marker to detect individuals facing elevated risk of stroke and death in the primary prevention settings.…”
Get full text