Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…LEGEND-T2DM will leverage the Observational Health Data Sciences and Informatics (OHDSI) community that provides access to a global network of administrative claims and electronic health record data sources, representing 190 million patients in the USA and about 50 million internationally. …”
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Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting by Martina A. McAteer, Daniel R. McGowan, Gary J. R. Cook, Hing Y. Leung, Tony Ng, James P. B. O’Connor, Luigi Aloj, Anna Barnes, Phil J. Blower, Kevin M. Brindle, John Braun, Craig Buckley, Daniel Darian, Paul Evans, Vicky Goh, David Grainger, Carol Green, Matt G. Hall, Thomas A. Harding, Catherine D. G. Hines, Simon J. Hollingsworth, Penny L. Hubbard Cristinacce, Rowland O. Illing, Martin Lee, Baptiste Leurent, Sue Mallett, Radhouene Neji, Natalia Norori, Nora Pashayan, Neel Patel, Kieran Prior, Thomas Reiner, Adam Retter, Alasdair Taylor, Jasper van der Aart, Joseph Woollcott, Wai-Lup Wong, Jan van der Meulen, Shonit Punwani, Geoff S. Higgins

“…While a centralised UK clinical imaging research infrastructure and open access federated data repository were considered necessary, there was ‘agreement without consensus’ regarding the requirement for a centralised UK preclinical imaging infrastructure. …”
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Factors associated with early childhood development: results from the Brazilian National Survey on Child Nutrition (ENANI-2019) by Gilberto Kac, Nadya Helena Alves-Santos, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Raquel Scincaglia, Paula Normando, Inês Rugani, Elisa Maria de Aquino Lacerda, Sandra Crispim, Alexandra Valeria Maria Brentani, Claudia Regina Lindgren Alves

“…For children aged 36–59 months, attendance to private daycare/school (β=0.08; p<0.01) was positively associated with DQ, and small for gestational age at birth (β=−0.05; p=0.01) and access to public health services (no-primary care) (β=−0.07; p<0.01) were inversely associated with DQ.Conclusions Adverse health, nutrition and learning factors predicted the ECD, demonstrating an inequitable environment for Brazilian children. …”
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Micronutrient levels of global tropical reef fish communities differ from fisheries capture by Conor Waldock, Eva Maire, Camille Albouy, Vania Andreoli, Maria Beger, Thomas Claverie, Katie L. Cramer, David A. Feary, Sebastian C. A. Ferse, Andrew Hoey, Nicolas Loiseau, M. Aaron MacNeil, Matthew McLean, Camille Mellin, Simon Ahouansou Montcho, Maria Lourdes Palomares, Santiago de laPuente, Mark Tupper, Shaun Wilson, Laure Velez, Jessica Zamborain‐Mason, Dirk Zeller, David Mouillot, Loïc Pellissier

“…However, small‐scale fisheries in some countries were already selective towards micronutrient mass, indicating policies that target improved access, distribution and consumption of fish could leverage this existing high micronutrient mass. …”
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Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017Research in context by Yi-Fan Wei, Li Ning, Yi-Lin Xu, Jing Ma, Dong-Run Li, Zan-Fei Feng, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Chun-Qing Lin, Ting-Ting Gong, Qi-Jun Wu, Jing-He Lang

“…Data were extracted from the Cancer Incidence in Five Continents (CI5 Ⅻ) and CI5plus databases (accessed in June 2024). Annual percent changes were computed to describe trends in age-standardized rates (ASRs) of OC and its subtypes. …”
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Role of three-dimensional computed tomography with humeral subtraction in assessing anteromedial facet coronoid fractures by Moayd Abdullah H Awad, MBBS, FRCSC, Michael Lapner, MD, FRCSC, Armin Badre, MD, MSc, FRCSC

“…In the first round, the evaluation was made based on all two-dimensional and 3D reconstruction images of the entire elbow; in the second round, the surgeons had access to images from the first round plus 3D reconstruction with humeral subtraction. …”
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Research on equity analysis and forecasting of nursing human resource allocation in Jiangxi Province, China by Yunyu Du, Zhiqin Xie, Zhen Yang, Wanyin Xiong, Li Zhou, Min Zhang, Suhua Zeng, Min Wang

“…These findings provide a foundation for optimizing future nursing resource allocation to ensure equitable access to healthcare services.…”
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Early diagnosis and the effect of treatment compliance on the prognosis and progression of glaucomatous optic neuropathy by S.V. Diordiychuk, A.V. Kuroyedov, N.E. Fomin, O.V. Gapon’ko, V.V. Gorodnichiy, I.V. Kondrakova, N.M. Sol’nov

“…These factors include early diagnosis, accessible and effective screening system, rational management strategy that implies the drug change to prevent the reduction in therapeutic effect, and patient adherence to treatment that involves explaining the causes and characteristics of disease cours e, potential complications with recommendation noncompliance, and a professional work a doctor with a patient.…”
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Effects of different monochromatic light on growth performance and liver circadian rhythm of Yangzhou geese by Yingqing Xu, Yi Tang, Yiyi Cheng, Wen Yang, Jie Liu, Binbin Guo, Gang Luo, Huanxi Zhu

“…The geese were provided with ad libitum access to food and water, and were raised for 70 days under a photoperiod of 16 hours of light and 8 hours of darkness. …”
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Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon by Noura Efietngab Atembeh, Jean Patrick Molu, Jeanne Valerie Emvoutou Maboulou, Boris Fominyam, Rodrigue Nanfack Dongmo, Gabriel Bertrand Zambo, Emilie Tchinda Tiecheu, Jeannette Tombi, Lucia Nkengazong, Serge Hubert Zebaze Togouet, Jean Louis Essame Oyono

“…Maintaining proper personal cleanliness, environmental sanitation through the building of functional and accessible faecal disposal facilities and drainages and abstaining from using the rivers as waste dumps are essential in this area to prevent parasitic helminth disease outbreaks.…”
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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…Dissemination of the outcomes of the study is expected via publication in a peer-reviewed journal, presentation at relevant conferences, and via social media, podcast presentations and open-access medical education resources.Registration details The trial was prospectively registered with the Australian New Zealand Clinical Trials Registry as ‘Pilot testing of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children’ (the DAISY Pilot Study).Trial registration number ACTRN12621000799853.…”
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Inequalities in utilization of maternal health services in Ethiopia: evidence from the PMA Ethiopia longitudinal survey by Asebe Hagos, Misganaw Guadie Tiruneh, Melak Jejaw, Kaleb Assegid Demissie, Lemlem Daniel Baffa, Demiss Mulatu Geberu, Getachew Teshale, Tesfahun Zemene Tafere

“…Therefore, implementing targeted interventions for the most disadvantaged groups can help to reduce inequality in accessing maternal health services.…”
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100% oxygen mobilizes stem cells and up-regulates MIF and APRIL in humans: a new point on the hormetic dose curve by Kent J. MacLaughlin, Gregory P. Barton, Julia E. MacLaughlin, Jacob J. Lamers, Matthew D. Marcou, Matthew J. O’Brien, Rudolf K. Braun, Marlowe W. Eldridge

“…A positive outcome presents the potential to create and refine oxygen treatment protocols, expand access, and optimize patient outcomes.MethodsHealthy 30–35-year-old volunteers were exposed to 100% normobaric oxygen for 60 min, M-F, for 10 exposures over 2 weeks. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Abstract In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). …”
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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

“…Methods A systematic review and meta-analysis were conducted using PubMed, Medline, Cochrane Library, Henari, African Journals Online (AJOL), Web of science, and Google Scholar to access studies up to December 6, 2024. The PRISMA guideline, JBI, and Newcastle Ottawa quality assessment scale checklists were used. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…Content analysis further identified six key research areas within this domain: identity authentication and data verification, secure access control, attack detection and perception, data security and protection, data backup and recovery, and attack assessment and attribution. …”
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Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…We inferred that the likely ancestry of these alleles was from C. jejuni and was later acquired by C. coli through recombination. Publicly accessible global genomic data from 16,120 Campylobacter genomes identified these mutations in approximately 6% of C. jejuni and C. coli isolates globally, with higher prevalence in samples from poultry in many countries, including Peru. …”
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Respectful maternity care and associated factors among mothers who gave birth at public health institutions in Debre Tabor town, Northwest Ethiopia: a mixed-methods study by Tadesse Ayana Fentie, Abayneh Aklilu Solomon, Mihretu Molla Enyew, Meseret Mekuriaw Beyene, Ayalew Kassie Melese, Alamirew Enyew Belay, Gebrie Getu Alemu

“…Additionally, adequate access to basic equipment and supplies should be given due attention to ensure respectful maternity care.…”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…These identified species have been deposited in GenBank™ under the accession numbers OM817461 (C. parvum FSA-1), OM817462 (C. parvum FSA-2), and OM817463 (C. parvum FSA-3) and revealed closed genetic identity with those species reported from human and other animal species in the same geographic location.ConclusionOverall, this study represents the first morphological and genetic identification of C. parvum isolated from fecal samples of fat sand rats trapped from periurban areas in Egypt. …”
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