STATE-BUILDING PROCESS IN UZBEKISTAN: MANY MILES TO GO by Gürhan Ünal

“…With the dissolution of USSR, newly independent states struggled tofunction as independent nation-states since the transition efforts fromCommunism to post-Communism created an uncharted area for the post-Sovietsocieties. Transition studies gained widespread attention with thedemocratization of Latin America and Southern Europe. …”
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Conflict-induced displacement in Pakistan: a sociological study of lived experiences of involuntary migration among Afghan immigrants by Kashif Iqbal, Sheng Hongcheng, Hu Liang

“…Charting future territories, we advocate for longitudinal and comparative analyses, recognizing the uncharted realm of gendered experiences in involuntary migration.…”
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A Multi-Dimensional Resource Allocation Scheme: In Beam Hopping Technique Enhanced MF-TDMA Satellite Systems by Yifeng Jin, Zhong Zheng, Hanyu Zheng, Minglong Pu, Junjie Zeng, Zihe Gao

“…Against the backdrop of the widespread deployment of 5G systems and humanity’s entry into a new era of sixth-generation mobile communication, countries are now turning their attention to exploring uncharted territories through satellite communication. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…Despite the blood-brain barrier (BBB) serving as a crucial gatekeeper, conveying environmental influences into the brain parenchyma, the contributions of BBB in ASD pathogenesis remain largely uncharted. Here we report that SHANK3, an ASD-risk gene, expresses in the BBB-forming brain endothelial cells (BECs) and regulates tight junctional (TJ) integrity essential for BBB’s barrier function. …”
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Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study by Chunqi Jiang, Bo Wang, Jun Wang, Yinuo Qu, Xin Zhang, Xin Zhang

“…IntroductionFatty liver disease is potentially linked to chronic kidney disease (CKD), yet the association between the Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated the correlation between FSI and CKD, aiming to elucidate the underlying links between these two conditions.MethodsThe relationship between FSI and CKD was evaluated using a weighted multivariate logistic regression model, and the curvilinear relationship between FSI and CKD was explored through smooth curve fitting. …”
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Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia by Vijay Murali Ravi Mythili, Ramya Lakshmi Rajendran, Raksa Arun, Vasanth Kanth Thasma Loganathbabu, Danyal Reyaz, ArulJothi Kandasamy Nagarajan, Byeong-Cheol Ahn, Prakash Gangadaran

“…This review explores uncharted territory beyond traditional therapies, focusing on the potential of two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) and artificial nanovesicles. …”
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Comprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study by Luis Carlos López-Romero, José Jesús Broseta, Marta Roca-Marugán, Noemí Máñez Ramírez, Julio Hernández-Jaras

“…Metabolomic analysis, which examines metabolites as the final products of cellular processes, is a powerful tool for identifying in vivo biochemical changes, serving as biomarkers of pathological abnormalities, and revealing previously uncharted metabolic pathways. Methods: A multicenter cross-sectional case-control study of adult patients diagnosed with XLH was conducted. …”
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Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease by Guangming Su, Ping Huang, Dan Liu, Guorui Xing, Ruochun Guo, Shenghui Li, Shao Fan, Lin Cheng, Qiulong Yan, Wei Yang

“…ABSTRACT The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. …”
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An Exploration of the Cellular Microenvironment of the Female Pig Urethra: Translational Insights for Urological Research by Agustín Cartes, Caroll Stoore, María Soledad Baquedano, Christian Hidalgo, Felipe Lillo, Eduardo Landerer, Galia Ramírez-Toloza, Rodolfo Paredes

“…The aim of this study was to explore the largely uncharted muscular structure of the female pig urethra, linking urethral muscle dysfunction to incontinence. …”
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Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea by Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang

“…Our findings indicate the diversity of archaeal viruses, their interactions with archaeal hosts, and their roles in the adaptation of the host.IMPORTANCEThe field of archaeal virology has seen a rapid expansion through the use of metagenomics, yet the diversity of these viruses remains largely uncharted. In this study, the complete genomes of 38 novel archaeal proviruses were identified for the following four dominant phyla: Halobacteriota, Thermoplasmatota, Thermoproteota, and Nanoarchaeota. …”
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Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species by Wenyao Lv, Zhijie Zhou, Lingli Xie, Xinyue Wang, Yifei Zhou, Lang Gui, Xiaoyan Xu, Yubang Shen, Jiale Li, Junqiang Qiu

“…However, the immunological mechanisms underlying co-infection by these pathogens remain largely uncharted. This study investigated the pathogenesis and host immune response in grass carp following concurrent infection with <i>A. hydrophila</i> and <i>A. veronii</i>. …”
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Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…The crucible of epidemics in the 21st century compels us to acknowledge the imperativeness of collective resilience and concerted efforts. As we navigate the uncharted territories of emerging infectious threats and persisting health challenges, the amalgamation of scientific innovation, proactive policy interventions, and unwavering global solidarity becomes indispensable. …”
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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life by Sebastiano Montante, Rym Ben-Othman, Nelly Amenyogbe, Asimenia Angelidou, Anita van den Biggelaar, Bing Cai, Yixuan Chen, Alansana Darboe, Joann Diray-Arce, Rebecca Ford, Olubukola Idoko, Amy Lee, Mandy Lo, Kerry McEnaney, Mehrnoush Malek, David Martino, Geraldine Masiria, Oludare A. Odumade, William Pomat, Casey Shannon, Kinga Smolen, The EPIC Consortium, Al Ozonoff, Peter Richmond, Scott Tebbutt, Ofer Levy, Beate Kampmann, Ryan Brinkman, Tobias Kollmann

“…Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted. To identify factors that may impact the trajectory of immune development, we conducted stringently standardized, high-throughput phenotyping of peripheral white blood cell (WBC) populations from 796 newborns across two distinct cohorts (The Gambia, West Africa; Papua New Guinea, Melanesia) in the framework of a Human Immunology Project Consortium (HIPC) study. …”
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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

“…High-dose IL-10 treatment may not achieve expected outcomes, raising the question of whether IL-10 has dose-dependency, or even uncharted side-effects from overdosing. We hypothesized that IL-10 has dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after MI.MethodsUsing RAW264.7 monocyte models, we examined whether administering differential doses of exogenous IL-10 (0–1,000 ng/mL) perturbs classic M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes of polarized Mφ or even alters the phenotypic transition of prospective M1 and M2 polarization. …”
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Bodies in Agony: Classical Sculpture and Violence in Herman Melville's works by Ronan Ludot-Vlasak

“…By releasing the darker energies which animate the figure of Apollo – a god “driven by a desire for transgression” in Marcel Détienne’s words – Melville’s writing subverts the immaculate and marmoreal antiquity fantasised by the champions of neoclassicism and opens up an unchartered territory within which agonizing pain and violence might only be glimpsed. …”
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Conquering myositis, beyond remission by Amber O'Connor, T G Sundaram

“…Akin to a stowed sailboat, limiting management of chronic illnesses such as idiopathic inflammatory myopathies (IIM) to diagnosis, investigations, and drug prescriptions, is like leaving the seas unchartered. The importance of holistic care, including psychological and social support, cannot be overemphasized. …”
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Shifting the lines of the British travel writing tradition: Marlow's vertical travel in Lord Jim by Isabelle LORÉAL

“…While the opening of the Suez Canal heralded the end of the period when it was still possible to discover unchartered territories on the surface of the earth, its drilling deep into the ground also signaled that exploration would need to become excavation, uncovering of what is layered stratigraphically under the surface. …”
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What is Legal Theory? by Marietta Auer

“…It suggests that interdisciplinary knowledge is a vital and indeed intrinsic part of legal scholarship. An unchartered space nevertheless remains between the disciplinary and the multi-, inter- and transdisciplinary forms of legal knowledge. …”
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Effective Facial Expression Recognition System Using Artificial Intelligence Technique by Imad S. Yousif, Tarik A. Rashid, Ahmed S. Shamsaldin, Sabat A. Abdulhameed, Abdulhady Abas Abdullah

“…ANNS are inspired by the neural architecture of human brain capable of learning and recognizing patterns in unchartered data after trained examples, on the other hand GAs come from fundamental principles underlying natural selection perform optimization process based-on evolutionary methods which includes fitness evaluation, comparison, selection, crossover, and mutation. …”
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Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…The sRNA-mediated regulation of type VI secretion system (T6SS) in Acinetobacter baumannii was unchartered. Previously, it was demonstrated that A. baumannii ATCC 17978 cells switch from T6− to T6+ phenotype, resulting in the loss of antibiotic resistance conferred by plasmid pAB3. …”
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