Association of expedited review programmes with postmarketing safety events of new drugs approved by the US food and drug administration between 2007 and 2017 by Bao Liu, Xingyue Zhu

“…Objective To explore the associations between the risks of postmarketing safety events of new drugs and the four expedited programmes of priority review, accelerated approval, fast track and breakthrough therapy established by the US Food and Drug Administration (FDA); and to investigate whether multiple uses of expedited programmes, and the combinations of expedited programmes with orphan designation, were relevant to different safety profiles.Design Cohort study.Setting USA.Participants All new drugs approved by the FDA between 1 January 2007 and 31 December 2017, followed up until 10 April 2021.Outcome measures Safety events included safety-related withdrawal, new boxed warning, drug safety communication, postapproval risk evaluation mitigation strategy and safety-related labelling changes. …”
Get full text

First insights into the spatio-temporal ecology of sympatric large carnivores in Niokolo-Koba National Park, Senegal by Robin Horion, Zoe Woodgate, Marine Drouilly

Get full text

Key components in the professional ethics of sign language interpreters in healthcare contexts: a qualitative study in Colombia by Nora Ellen Groce, Samia Hurst, Laura Catalina Izquierdo Martínez, Angela Martínez-R, Jessica Cuculick, Minerva C Rivas Velarde

Get full text

Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review by Adekunle Babajide Rowaiye, Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua, Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu

Get full text

Detection of Viable but Nonculturable E. coli Induced by Low-Level Antimicrobials Using AI-Enabled Hyperspectral Microscopy by MeiLi Papa, Aarham Wasit, Justin Pecora, Teresa M. Bergholz, Jiyoon Yi

Get full text

Enhancing prediction of wildfire occurrence and behavior in Alaska using spatio-temporal clustering and ensemble machine learning by A. Ahajjam, M. Allgaier, R. Chance, E. Chukwuemeka, J. Putkonen, T. Pasch

Get full text

The Role of Geographic Information Systems (GIS) in Participatory Conservation of Heritage Areas by Hamid Salimi, Somayeh Fadaei Nezhad Bahramjerdi, Rana Tootoonchi

“…A conceptual model is presented through a literature review, followed by an evaluation of five case studies from Iran, The USA, Finland, Egypt, and Spain that have utilized GIS in participatory planning processes. …”
Get full text

Research of Regenerative Braking Strategy for Electric Vehicles by Van Nghia Le, Hoang Phuc Dam, Trong Hoan Nguyen, S. V. Kharitonchik, V. A. Kusyak

“…In order to test the adequacy of the simulation model to reproduce the relationship between the operating parameters of electric vehicles various systems and evaluate their ability to regenerate energy during braking the simulation results were compared with the actual experimental data published by the Lab Avt research laboratory (USA). The relative error of the mathematical modeling results of the braking energy regeneration processes is 4.5 %, which indicates the adequacy of the electric vehicle simulation model and the possibility of its using as a base for research and comparison of the energy efficiency of various regenerative braking strategies. …”
Get full text

Drug-Induced Myoclonus: A Systematic Review by Jamir Pitton Rissardo, Ana Letícia Fornari Caprara, Nidhi Bhal, Rishikulya Repudi, Lea Zlatin, Ian M. Walker

Get full text

PACE Technique to Error Categories: Its Effectiveness in Improving Word Problem Performance in Mathematics among the 7th Grade Students by Roghene A. Coloma, Florante P. Ibarra, Amirul Mukminin, Lenny Marzulina, Herri Mulyono, Kasinyo Harto

“… This research determined the effectiveness of the PACE (Present the error, Analyze the error, Correct the Error, Explain the error) technique in improving the mathematics performance in solving word problems among 7th Grade students in Harnett Central Middle School, North Carolina, USA. The study utilized quasi-experimental research design with a validated researcher-made 7th Grade Mathematics test as the main instrument. …”
Get full text

Laboratory formation of micro-penitentes at temperatures and pressures relevant to Earth and other worlds by Daniel Floyd Berisford, Jeffrey Tyler Foster, Jacob Kosberg, Benjamin Furst, Michael Joseph Poston, Takuro Daimaru, Maggie Lang, Lavina Backman, Kevin Peter Hand

Get full text

Insecticides may facilitate the escape of weeds from biological control by Elizabeth K. Rowen, Kirsten Ann Pearsons, Richard G. Smith, Kyle Wickings, John F. Tooker

“…Methods Here, in two 3-year corn-soy rotations in Pennsylvania USA, we investigated a PPM approach to insect management compared to an integrated pest management approach (IPM) and a “no (insect) pest management” (NPM) control. …”
Get full text

Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…Zahra Izadiyan,1 Misni Misran,1 Katayoon Kalantari,2 Thomas J Webster,3,4 Pooneh Kia,5 Noor Ashyfiyah Basrowi,1 Elisa Rasouli,6 Kamyar Shameli7 1Department of Chemistry, Universiti Malaya, Kuala Lumpur, Malaysia; 2Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 3Biomedical Engineering, Hebei University of Technology, Tianjin, People’s Republic of China; 4School of Engineering, Saveetha University, Chennai, India; 5Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 6Department of Electrical and Electronics Engineering, Nanyang Technological University, Nanyang, Singapore; 7School of Medicine, Institute of Virology, Technical University of Munich, Munich, GermanyCorrespondence: Zahra Izadiyan; Kamyar Shameli, Email zahra_izadiyan@yahoo.com.my; kamyarshameli@gmail.comAbstract: Liposomal nanomedicines have emerged as a pivotal approach for the treatment of various diseases, notably cancer and infectious diseases. …”
Get full text

Hazard assessment for a pharmaceutical mixture detected in the upper Tennessee River using Daphnia magna by D. Wolfe, M. Schorr, M. Hanson, C.H. Nelson, S.M. Richards

“…In a 2008 study, 13 pharmaceuticals, ranging in amounts from 0.0028 to 0.1757 µg/l, were identified in the Tennessee River, USA and its tributaries. In order to address the need for risk assessment of environmentally relevant pharmaceutical mixtures, Daphnia magna 21-d life cycle tests were performed on a mixture of 11 of the 13 pharmaceuticals as well as on the individual components of the mixture. …”
Get full text

Thermal Decarboxylation of Betacyanins in Red Beet Betalain-Rich Extract by Agnieszka Kumorkiewicz, Katarzyna Sutor, Boris Nemzer, Zbigniew Pietrzkowski, Sławomir Wybraniec

Get full text

Prevalence and Antimicrobial Resistance of Escherichia coli Isolated from Various Meat Types in the Tamale Metropolis of Ghana by Frederick Adzitey, Prince Assoah-Peprah, Gabriel A. Teye, Anou M. Somboro, Hezekiel M. Kumalo, Daniel G. Amoako

“…Isolation of Escherichia coli was done using the procedure according to the USA-FDA Bacteriological Analytical Manual. Antibiotic resistance patterns in the Escherichia coli isolates were determined by the Kirby-Bauer disk diffusion method against 8 antibiotics. …”
Get full text

Application of Perclose ProGlide closure device in transbrachial endovascular intervention by Peng Zhao, Yao Yao, Quan Yang, Ning Wang, Liang Wang, Qianquan Ma, Wenchao Zhang

“…Abstract This study aims to assess the clinical efficacy and feasibility of the Perclose ProGlide Suture-Mediated Closure System (Abbott Vascular, Redwood City, CA, USA) for transbrachial access. A total of 100 patients from July 2020 to December 2023 were included in this retrospective study. …”
Get full text

Why heads matter in palaeoanthropology: The impacts and consequences of collecting skulls by Lauren Schroeder, Paige Madison, Rebecca R. Ackermann

Get full text

The study of innovative activity features of organizations in the field of fish farming and fishing in 2003–2022 taking into account the analysis of parameters results of intellect... by Е. V. Leun, S. E. Pchelkin, Т. N. Gupalova

“…The article considers four groups of results of intellectual activity of Russia, the USA, the European Union and China in the field of fish farming and fisheries for the period 2003–2022. …”
Get full text

Sustaining reductions in postoperative nausea and vomiting after evidence-based practice initiative: A success story by Christopher A Smith, Richard E Haas

Get full text