Design Optimization of a 3-PUU Parallel Machine for Friction Stir Welding Robots by Eka Marliana, Latifah Nurahmi, Arif Wahjudi, I. Made Londen Batan, Guowu Wei

“…To address this issue, a 3-PUU (Prismatic and Universal Joints) parallel machine with 3-DoF (Degrees of Freedom) translational movement is utilized to support the FSW robot’s tool head, allowing the robot to operate over a larger horizontal workspace. …”
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An original method of direct calculation for the identification of the last hinge and the definition of the deformative state at collapse by Roberto Maria De Salvo

“…If, for each hinge, the product between the plastic moment and the correspondent algebraic sum is made, this product has to be surely positive, due to the verses concordance. This can be translated in k+1 inequalities, with each one furnishing a lower limit for the parameter from which the articulated motion depends. …”
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Driving Innovation to Support Pupils with SEND Through Co-Production in Education and Research: Participatory Action Research with 22q11.2 Deletion Syndrome Families in England by Michelle Jayman, Sophie Edmonds, Maria Gudbrandsen

“…However, evidence suggests pupils’ learning and wellbeing needs are often missed or unmet and legislation designed to increase families’ decision-making in education provision has not been translated into practice. The current participatory action research study investigated the perceptions and experiences of a specific population of SEND pupils in mainstream schooling—CYP with 22q11.2 deletion syndrome (22q). …”
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Occupational Risks in Occupational Therapy Service Learning: A Single-Site “Fear Factor” Study in South Africa by Deshini Naidoo, Pragashnie Govender, Stephanie Nicole Naidoo, Naledi Ngubane, Zamankosi Nkosi, Aziza Mulla

“…These insights into the perceived occupational risk factors can be translated into actionable strategies to improve the preparation of health science students for service-learning, including coping skills to deal with the demands of service-learning.…”
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Form destabilization: Between reality and projection by Mojsilović Mila

“…In the plane of architectural production, the neutral framework of universal space for the production of diversity is translated into a digital one. A new definition of values and criteria, based on variability and potentiality, serves to introduce a metanarrative of multiplicity in terms of manifold ways of decoding the world and reality. …”
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Power consumption modeling and optimization for NB-IoT eDRX by Xin JIAN, Yixiao WEI, Yuqin LIU, Jian SONG, Xiaoping ZENG, Xiaoheng TAN

“…To extend the battery life of massive machine type devices (MTD),narrow-band Internet of things (NB-IoT) system extended discontinuous reception (eDRX) mechanism of LTE to the maximum as well as introduced a lower power state named as power saving mode (PSM).Three Markov models were established for three typical NB-IoT traffic scenarios,which called mobile autonomous reporting periodic report (MAR-P),mobile autonomous reporting exception report (MAR-E),software update/reconfiguration (SUR).The states of each Markov model were the working status of MTDs,including connected,idle and PSM state,in which the connected state was divided into random access state and data translating/receiving state to further evaluate the additional power consumption caused by collisions from massive MTDs concurrent access.Thereby,the power consumption and delay models with respect to each traffic scenarios were derived.Since the frequency of MAR-P traffic was far greater than the other two,the battery life of this traffic case with its optimal design choice was comprehensively analyzed.Numerical results show that,the battery life is mostly influenced by transmission period,maximum number of random access attempts,maximum number of data transmissions and traffic load,which can be maximized by appropriate parameters setting up.These works provide good references for NB-IoT device behavior modeling and optimization design.…”
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Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds by Adam Kokotkiewicz, Anna Badura, Żaneta Tabaczyńska, Andżelika Lorenc, Adam Buciński, Maria Luczkiewicz

“…The change of distillation mode from HD to SDE significantly increased the oil yield of whole seeds (from 2.8 to 5.8% for 6 h processing) while maintaining its high phthalide content (62.5%), which translated to an increase in the total phthalide yield from 19.4 to 36.0 g/kg.…”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…We detected a bivalent domain in the CYP1A promoter enhancer comprising both activating and repressive histone post-translational modifications. Activating modifications, relative to repressive ones, showed greater increases in response to PAH in sensitive embryos, relative to tolerant, consistent with greater gene activation. …”
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis by Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson

“…This study evaluated the histopathological and inflammatory components of bleomycin-induced pulmonary fibrosis in mouse and sheep models, in terms of their ability to translate to the human IPF. Merino sheep (n = 8) were bronchoscopically administered with two bleomycin infusions, two weeks apart, into a caudal lung segment, with a saline (control) administered into a caudal segment in the opposite lung. …”
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Continuum of Care - Building bridges between different phases of the patient's pathway by Michael Adolph, Marek Lichota

“…While guidelines on nutritional care exist, translating these guidelines into individualized nutritional plans is essential for providing optimal patient care. …”
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Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects by Andrew Wofford, Austin Bow, Steven Newby, Seth Brooks, Rachel Rodriguez, Tom Masi, Stacy Stephenson, Jack Gotcher, David E. Anderson, Josh Campbell, Madhu Dhar

“…Gelfoam®, a commonly used clinical biomaterial, can serve as a scaffold to deliver and maintain MSCs to the defect site. Translating this strategy to preclinical animal models provides hope for bone tissue engineering.…”
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Towards the praxis of a sustainable knowledge‑based economy by Agnieszka Klimska

“…Implementation of the preferred directions of development, requires not so much efficient, but proper management, i.e. one which would translate itself onto the plane of decision-making and, subsequently, that of application. …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…In addition, we discovered that circANKRD17 has an open reading frame and can be translated into a novel 571-amino-acid protein that promotes lipid metabolism. …”
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The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons by Catherine Schaefers, Simone Rothmiller, Horst Thiermann, Theo Rein, Annette Schmidt

“…However, these often apply viral vectors, feeder cells, or antibiotics to generate hiPSC and MNs, limiting their translational potential. In this study, a virus-, feeder-, and antibiotic-free method was used for reprogramming hiPSC, which were maintained in culture medium produced under clinical good manufacturing practice. …”
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Re-Calibrating Network by Refining Initial Features Through Generative Gradient Regularization by Naim Reza, Ho Yub Jung

“…Notably, this refinement in features translates to improved generalization and the proposed method also eliminates the necessity of total retraining of the target network. …”
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Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids by Mark C. Allenby, Asma Tahlawi, José C. F. Morais, Kang Li, Nicki Panoskaltsis, Athanasios Mantalaris

“…Herein, we propose HFs to improve 3D cell culture nutrient and metabolite diffusion, increase culture volume and cell density, and continuously harvest products for translational cell therapy biomanufacturing protocols.…”
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The impacts on population health by China's regional health data centers and the potential mechanism of influence by Jiaoli Cai, Yue Li, Peter C Coyte

“…Background China recently established a series of pilot regional health data centers with a mandate to acquire, consolidate, analyze, and translate data into evidence for health policy decision-making. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The combination of clinical drugs targeting different symptoms with smart hydrogels to achieve asynchronous releases is highly translational and challenging. Here, a hierarchical bioactive hydrogel (OACDP) is designed with asynchronous release based on PD pathology. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…In conclusion, the high phenotypic and molecular similarity allows the established PDXs to serve as potential preclinical models for future translational research of OCCC.…”
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Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples by Maxime Lafond, Allison Payne, Cyril Lafon

“…While the clinical indications explored in this review are at different points in the clinical evaluation path, based on the ever expanding research being conducted in preclinical realms, it is clear that additional clinical applications of therapeutic ultrasound that utilize a myriad of bioeffects will continue to grow and improve in the coming years.Conclusions: Therapeutic ultrasound will continue to improve in the next decades as the combination of transducer technology and treatment monitoring techniques will continue to evolve and be translated in clinical settings, leading to more personalized and efficient therapeutic ultrasound mediated therapies.…”
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