Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry by Ron M. Versteegen, Raffaella Rossin, Ivo A. W. Filot, Freek J. M. Hoeben, Arthur H. A. M. van Onzen, Henk M. Janssen, Marc S. Robillard

“…Abstract The bioorthogonal tetrazine-triggered cleavage of trans-cyclooctene(TCO)-linked payloads has strong potential for widespread use in drug delivery and in particular in click-cleavable antibody-drug conjugates (ADCs). However, clinical translation is hampered by an inverse correlation between click reactivity and payload release yield, requiring high doses of less reactive tetrazines to drive in vivo TCO reactions and payload release to completion. …”
Get full text

Rechtsgeschichte als Geschichte von Normativitätswissen? by Thomas Duve

“…Looking at legal history as a continuous process of the translation – and thus the production – of normative knowledge can provide an analytical framework that helps overcome these constraints. …”
Get full text

Study on the Generalized Displacement Boundary and Its Analytical Prediction for Ground Movements Induced by Shield Tunneling by Qianlong Tang, Fudong Chen, Mingfeng Lei, Binbin Zhu, Limin Peng

“…Then, a universal pattern of displacement boundary condition around the tunnel cavity is originally introduced, which is solved as the combination of three fundamental deformation modes, namely, uniform convergence, vertical translation, and ovalization. The expression for the above-mentioned displacement boundary condition is derived, by imposing which the analytical solution for ground movements, based on the stress function method, is proposed. …”
Get full text

State of the digital age: modeling of institutional transformations by D. V. Shelokov

“…The article considers the main areas of application of social modeling in public administration: assessment of the effectiveness of management bodies in the monitoring mode, development of strategic decisions, their translation into technological formats, digital representations of strategies and technologies.…”
Get full text

Study on the Instability Mechanism and Grouting Reinforcement Repair of Large-Scale Underground Stopes by Chengyu Xie, Nan Jia, Liwen He

“…The damage mode of instability collapse is a combination method of wedge collapse, circular arc rotation, triangular translation, and strip slip. According to the multiphysics coupling numerical calculation, the diffusion radius of the grouting slurry is 12 m, exhibiting an elliptical distribution. …”
Get full text

Limits and Risks of Digital Transformation by T. S. Akhromeeva, G. G. Malinetskiy, S. A. Posashkov

“…It is very likely that the tester of artificial intelligence systems will become one of the mass professions in the close future.We give examples to show that the "translation" from "continuous" to "discrete" language can lead to qualitatively different behavior of mathematical models. …”
Get full text

A Distribution Agnostic Rank-Based Measure for Proximity Search by Mayur Garg, Ashutosh Nayak, Rajasekhara Reddy Duvvuru Muni

“…However, these metrics are limited by their dependency on the distribution of data along different dimensions, making them sensitive to scaling and translation. The performance also suffers as the number of dimensions increase. …”
Get full text

Transferência de política pública e o papel do embaixador de políticas: dos Parques-Biblioteca de Medellín para os Centros Comunitários da Paz no Recife by Ana Pollinny de Freitas, Eliane Superti, Liliana Ramalho Fróio

“…Conclusions: It is identified that the translation of the policy was emulation; that is, Recife’s PP bears similarity to Medellín’s, with adaptations and adjustments to its reality. …”
Get full text

RUKUN NASUTION (1928-1998) AND HIS POETRY CORPUS: A Preliminary Study by Hasan Asari, Yusnaili Budianti

“…This corpus includes three types: 1) his orinigal compositions; 2) translations from Malay to vernacular Mandailing language; and 3) translation of poetries written in Malay script into Latin script. …”
Get full text

Le dessin de design en tant qu’œuvre en soi by Airton Cattani

“…Design drawing can therefore be considered as a kind of translation of the designer’s work into a wordless language, which can supposedly be decoded universally. …”
Get full text

Kinematics and Mechanical Properties of Knees following Patellar Replacing and Patellar Retaining Total Knee Arthroplasty by Rongying Huang, Yanqiang Liu, Jun Zhu

“…By contrast, patellar replacement had a significant influence on the patellofemoral joint; patellar internal rotation, external rotation, and medial-lateral translation were all increased. Moreover, the stress distribution on patellar prostheses was altered, resulting in an increased surface maximal equivalent stress on the corresponding area. …”
Get full text

Leches a base de plantas: Nuez de marañón (anacardo) by Jamie Zeldman, Daniela Rivero-Mendoza, Wendy J. Dahl

“…Dahl, translated by Daniela Rivero-Mendoza, and published by the UF/IFAS Food Science and Human Nutrition Department. https://edis.ifas.ufl.edu/fs418 …”
Get full text

Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity by Ponraj Prabakaran, Abhinav Gupta, Sambasiva P. Rao, Deepak Rajpal, Maria Wendt, Yu Qiu, Partha S. Chowdhury

“…These InvDs utilize all three reading frames during translation, producing distinct amino acid profiles enriched in histidine, proline, and lysine in CDR-H3s of antibodies with potential functional diversity. …”
Get full text

Primordial Germ Cells: Current Knowledge and Perspectives by Aleksandar Nikolic, Vladislav Volarevic, Lyle Armstrong, Majlinda Lako, Miodrag Stojkovic

“…Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer. Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility.…”
Get full text

Adipose-Derived Stem Cells Exosomes Improve Fat Graft Survival by Promoting Prolipogenetic Abilities through Wnt/β-Catenin Pathway by Kexin Chen, Jiachao Xiong, Sha Xu, Minliang Wu, Chunyu Xue, Minjuan Wu, Chuan Lv, Yuchong Wang

“…In summary, our results provide a theoretical basis for the clinical translation of hADSC-Exo in fat grafting.…”
Get full text

Teaching responsible chemistry: a challenge-based learning framework for the implementation of RRI courses in tertiary chemistry education by Mehlich Jan

“…This paper proposes a course concept that aims at filling a gap in the translation of RRI principles into tertiary chemistry education practice. …”
Get full text

Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…Moreover accumulating in vitro data confirm that TKIs, interacting with the TCR and other signalling molecules, carry potent immunomodulatory effects, being involved in both T-cell and B-cell response. Translation to the clinical setting revealed that treatment with Imatinib can achieve encouraging responses in patients with autoimmune diseases and steroid-refractory cGVHD, showing a favourable toxicity profile. …”
Get full text

English Grammar Error Correction Algorithm Based on Classification Model by Shanchun Zhou, Wei Liu

“…On the basis of summarizing and analyzing previous research works, this paper expounded the research status and significance of English grammar error correction algorithm, elaborated the development background, current status, and future challenges of the classification model, introduced the methods and principles of feature extraction method and dynamic residual structure, constructed a basic model for English grammar error correction based on the classification model, analyzed the classification model and translation model of English grammar error correction, proposed the English grammar error correction algorithm based on the classification model, performed the analyses of the model architecture and model optimizer of the grammar error correction algorithm, and finally conducted a simulation experiment and its result analysis. …”
Get full text

(SPT-)LSM theorems from projective non-invertible symmetries by Salvatore D. Pace, Ho Tat Lam, and Ömer M. Aksoy

“…In this paper, we investigate the consequences of projective algebras formed by non-invertible symmetries and lattice translations in a generalized $1+1$D quantum XY model based on group-valued qudits. …”
Get full text

Psychometric Properties of Diabetes Management Self-Efficacy in Thai Type 2 Diabetes Mellitus Patients: A Multicenter Study by Monthida Sangruangake, Chananya Jirapornkul, Cameron Hurst

“…The aims of this study were to translate and psychometrically evaluate the Thai version of diabetes management self-efficacy scale (T-DMSES) and to examine its association with HbA1c control in diabetic individuals. …”
Get full text