Construction and validation of a predictive model for the risk of myelosuppression after first-line chemotherapy in patients with advanced colorectal cancer by WANG Xuexing, ZHANG Rong, CHU Jie, LIU Zhijin

“…The World Health Organization classification standard for acute and subacute toxicity of anticancer drugs were used as the standards for diagnosing CIM, and the patients were subsequently categorized into CIM and non-CIM groups. …”
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The Role of Polyphenols in Abiotic Stress Tolerance and Their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals by Muhammad Junaid Rao, Bingsong Zheng

“…We discussed how various abiotic stresses, including heat and chilling stress, drought, salinity, light stress, UV radiation, nanoparticles stress, chemical stress, and heavy metal toxicity, modulate phenylpropanoid metabolism and trigger the accumulation of specific polyphenolic compounds. …”
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Antihyperglycemic Potential of Dried Powder Combination of Hygrophila auriculata and Cordia macleodii: In Vivo Study in Sprague Dawley Rats by Farooq M. Almutairi

“…The powders were macerated in methanol, evaporated, and further processed. Acute toxicity was assessed by administering flower powder to rats in doses from 5 mg/kg to 5,000 mg/kg, determining LD50 values per OECD guidelines. …”
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Hydrogen sulfide removal from biogas using chemical absorption technique in packed column reactors by M.B. Kulkarni, P.M. Ghanegaonkar

“…The toxicity and corrosion potential of hydrogen sulfide in raw biogas underlines the need for biogas purification. …”
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Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition by Huanyu Chen, Jun Liu, Zhichao Cao, Jiajia Li, Hong Zhang, Qianqian Yang, Jian Cheng, Yuxian Shen, Kewu He

“…Abstract Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been developed. …”
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Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo by Atik Ismiyati, I. Wayan Arsana Wiyasa, Dwi Yuni Nur Hidayati

“…Therefore, this may provide an antioxidant therapy for attenuating the ovarian toxicity found in the DMPA therapy.…”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…The current standard of care for cutaneous leishmaniasis (CL) is organic antimonial compounds, but the administration of these compounds is complicated by a low therapeutic - toxic index, as well as parenteral administration. …”
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Virtual screening, molecular docking and identification of umami peptides derived from Oncorhynchus mykiss by Wenzhu Zhao, Lijun Su, Shitong Huo, Zhipeng Yu, Jianrong Li, Jingbo Liu

“…Subsequently, water-soluble and toxicity screening were performed by Innovagen and ToxinPred software, respectively. …”
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A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA by Andrew V. Doodnauth, Miriam M. Klar, Zohra R. Malik, Krunal H. Patel, Samy I. McFarlane

“…However, immune-related renal adverse events remain low, representing only a small incidence of reported cases. Common renal toxicity described includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis. …”
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Spinach ameliorates dietary oxidized tallow-induced NAFLD by regulating inflammatory cytokines, peroxisome proliferator-activated receptors, and antioxidant systems by Neelab, Alam Zeb, Muhammad Jamil

“…Purpose: This study aimed to evaluate the ability of Spinacia oleracea dried powder in protecting rabbits from the toxicity caused by oxidized-tallow. Methods: Oxidized tallow and spinach powder were administered to the rabbits. …”
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Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study by JiSuk Lee

“…The study suggests that triterpene esters from U. rhynchophylla could represent a new class of potent HIV-1 PR inhibitors with less toxicity, suitable for combination antiretroviral therapy for AIDS.…”
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Advances in electrochemical sensors for naproxen detection: Mechanisms, performance factors, and emerging challenges by Seyed Saman Nemati, Gholamreza Dehghan, Jafar Soleymani, Abolghasem Jouyban

“…However, its use has complications such as changes in kidney function, severe gastrointestinal lesions, and increased bleeding after surgery. In addition, the toxicity of NAP or its metabolites affects the organisms in the ecosystem. …”
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Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms by Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello

“…Eugenol and methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically with terbinafine, providing effective antifungal treatment with minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense <i>C. albicans</i> biofilm and disrupted the fungal cell membrane. …”
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Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach by Riska Ayu Sutriyansyah, Muhamad Hilmi Ihsanul Iman, Cahya Ajeng Valenta Tresna Sulung, Nelly Indira Kusuma Wardani, Arif Nur Muhammad Ansori

“…This peptide is predicted to have high antigenicity, non-allergenicity and non-toxicity. This study concluded that peptide 6E is a promising vaccine candidate. …”
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Role of Cyclosporine in Crohn's Disease by CN Williams

“…Consequently, there is a requirement for monitoring of blood levels. There is renal toxicity, particularly when prior renal disease is present, when nephrotoxic drugs arc used concomitantly and in the elderly. …”
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A Prospective Study Assessing Tumour Response, Survival, and Palliative Care Outcomes in Patients with HIV-Related Kaposi's Sarcoma at Queen Elizabeth Central Hospital, Blantyre, M... by H. Francis, M. J. Bates, L. Kalilani

“…Tumour response, survival, and chemotherapy-related toxicities were documented. Palliative care outcomes were assessed using the African Palliative Care Association (APCA) Palliative Outcome Scale (POS). …”
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Surface State Treatment of Carbon Dots Using Sulphur Dioxide Isotherm by L. Natrayan, Dhinakaran Veeman, Pravin P. Patil, V. Swamy Nadh, P. Balamurugan, Muse Degefe Chewaka

“…Low toxicity carbon dots are combating the disadvantages of quantum dots. …”
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Drugs from poisonous plants: Ethnopharmacological relevance to modern perspectives by Bhagya Lakhmi Rajbongshi, Ashis K. Mukherjee

“…While some plants are known for their toxicity, they also contain beneficial phytochemicals that are important for both plants and humans, indicating their dual nature. …”
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Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2 by Niti Yashvardhini, Amit Kumar, Deepak Kumar Jha

“…Further, physicochemical properties, allergenicity, toxicity, and stability of RdRp protein were evaluated to demonstrate the specificity of the epitope candidates. …”
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Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production by V. Bocci, G. Valacchi, F. Corradeschi, G. Fanetti

“…While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be elicited in human blood with practically no toxicity. On the other hand plasma and cells are endowed with a powerful antioxidant system so that a fairly wide range of O3 concentrations between 40 and 80μ g/ml per gram of blood (˜0.83-1.66 mM) are effective but not deleterious. …”
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