Lyophilized and Oven-Dried <i>Manilkara zapota</i> Extracts: Characterization and <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Analyses by María Fernanda Rivas-Gastélum, Patricia Ariadna Galindo-Castillo, Juan Esparza-Sánchez, Miriam Irene Jiménez-Pérez, Yocanxóchitl Perfecto-Avalos, Luis Eduardo Garcia-Amezquita, Diego E. Navarro-López, Edgar R. López-Mena, Eugenio Sánchez-Arreola, Juan Pablo Tamayo-Martínez, Humberto L. Mendoza-Figueroa, María Magdalena Crosby-Galván, Elsa Margarita Crosby-Galván, Jorge L. Mejía-Méndez, Angélica Lizeth Sánchez-López

“…It was noted that the antibacterial and antioxidant activities of extracts were weak due to their MIC (>1000 μg/mL) and IC₅₀ (>2000 μg/mL) values. Still, the toxicity of extracts was poor against <i>Artemia salina</i> nauplii. …”
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A key technology for synergistic backfilling of coal-based solid waste and high-salinity wastewater by Shuning DONG, Shujiang YU, Xingling DONG, Buqin ZHANG, Xiaoming GUO, Xiaodong WANG, Kai WANG, Shibin ZHU, Boqiang WU, Lei LIU

“…The assessment results obtained using Nemerow’s pollution index and extraction toxicity tests indicate that the leachate from the solidified filling paste exhibited a comprehensive pollution index of heavy metals of 0.25, rated as “Safety” according to the grading criteria for comprehensive pollution assessment. …”
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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…Dose escalation followed a modified toxicity probability interval-2 design. Objectives included evaluation of safety, dose-limiting toxicity, recommended phase II dose, pharmacokinetic (PK) and pharmacodynamic (PD) parameters, and antitumor activity.Results 27 patients (median age 66 years (range, 33–85); median of 4 prior systemic therapies (range, 2–9)) with ovarian (70%), fallopian tube (15%), or primary peritoneal (15%) cancer received SL-172154. …”
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Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature by Nicole M. Agostino, Rebecca Gingrich, Joseph J. Drabick

“…These heavily pretreated patients sustained very prolonged periods of stable disease (median of 12 months) with very little toxicity and excellent quality of life. The activity of this agent in patients who had failed prior therapies directed against the VEGFR and mTOR suggests that therapy targeting the ligand, VEGF, is still a viable approach in these patients and deserves further study.…”
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Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment by Lu Y, Li Z, Zhu X, Zeng Q, Liu S, Guan W

“…However, their clinical translation is hindered by the negative electrical properties, sensitivity to hydrolytic enzymes, and systemic toxicity. Recently, various CDN delivery systems have made significant progress in addressing these issues, either through monotherapy or in combination with other treatment modalities. …”
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Exploration on the Interaction Ability of Antitumor Compound Bis-[2,6-difluoro-N-(hydroxyl-<κ>O)benzamidato-<κ>O]dibutylitin(IV) with Human Peroxisome Proliferator-Activated Recept... by Jiaqi Mai, Yunlan Li, Xiaozhi Qiao, Xiaoqing Ji, Qingshan Li

“…Diorganotin(IV) antitumor compound bis-[2,6-difluoro-N-(hydroxyl-<κ>O)benzamidato-<κ>O] (DBDF2,6T) was one of the novel patent organotin compounds with high antitumor activity and relatively low toxicity. In this study, several methods were used to study the interaction between DBDF2,6T and hPPARγ protein, including fluorescence quenching, three-dimensional (3D) fluorescence, drug affinity responsive target stability (DARTS), ultrafiltration-LC, and molecular docking. …”
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Association between air pollution and osteoporosis: A systematic review by Prabowo Nurhasan Agung, Soetrisno, Nurwati Ida, Ardyanto Tonang Dwi, Poncorini Eti, Nurudhin Arief, Dirgahayu Paramasari

“…These mechanisms include oxidative stress, systemic inflammation, and heavy metal toxicity in women disproportionately, older adults and urban populations. …”
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Role of Copper and Zinc Ions in the Hydrolytic Degradation of Neurodegeneration-Related Peptides by Valentina Pirota, Enrico Monzani, Simone Dell’Acqua, Chiara Bacchella

“…Spontaneous cleavage reactions normally occur in vivo on amino acid peptide backbones, leading to fragmentation products that can have different physiological roles and toxicity, particularly when the substrate of the hydrolytic processes are neuronal peptides and proteins highly related to neurodegeneration. …”
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Bio-Tribocorrosion of Titanium Dental Implants and Its Toxicological Implications: A Scoping Review by Sumit Gaur, Rupali Agnihotri, Sacharia Albin

“…However, further validation of the role of bio-tribocorrosion on the durability of the Ti dental implants and Ti toxicity is warranted through clinical trials.…”
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The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment by Delia Nelson, Scott Fisher, Bruce Robinson

“…The “Trojan Horse” approach of intratumoural delivery aims to promote immune-mediated destruction by inducing microenvironmental changes within the tumour at the same time as avoiding the systemic toxicity that is often associated with more “full frontal” treatments such as transfer of large numbers of laboratory-expanded tumor-specific cytotoxic T lymphocytes or large intravenous doses of cytokine. …”
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DISTRIBUTION AND POTENTIAL OF CAMELLIA SPP. IN THE CENTRAL HIGHLANDS, VIETNAM, FOR DEVELOPING HIGH-VALUE PRODUCTS IN THE FOOD INDUSTRY by Thi Thang Long Nguyen, Vu Mai Quynh Luong

“…Camellia extract does not cause acute toxicity and has a blood sugar-lowering effect. Vietnam has much experience growing green tea; the total green tea growing area is 131,200 hectares. …”
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Construction of a Multicellular Communication Network Model for Cell Co-Culture Technology and Evaluation of Its Simulation Capability by Yuan-Yuan Geng, Chao Wei, Guo-Fei Chen, Bai-Xia Zhang

“…Results: The outputs generated by the model developed in this study showed that nimodipine inhibited smooth muscle contraction, due to the overload of Ca2+ and the toxicity of excitatory amino acids, and protected neurons and vascular endothelial cells by supporting cell proliferation and inhibiting cell apoptosis. …”
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Advances in Illuminating Prostate Cancer with Emerging Phototherapies by Ali Usman

“…Functionalized nanoparticles, such as those targeting prostate-specific membrane antigen (PSMA), enhance the precision of therapeutic delivery, reducing systemic toxicity. Combination strategies incorporating PDT and PTT with conventional modalities, including surgery, chemotherapy and immunotherapy, have demonstrated synergistic effects, leading to better therapy sensitization. …”
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PEGylated Cisplatin Nanoparticles for Treating Colorectal Cancer in a pH-Responsive Manner by Wei Li, Yongjun Sun, Jian Chen, Zhibin Jiang, Jinbao Yang

“…Cisplatin cannot target CRC cells and has notable toxicity, which significantly limits its clinical application. …”
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Monosodium glutamate (MSG) exposure induced oxidative stress and disrupted testicular hormonal regulation, exacerbating reproductive dysfunction in male WISTAR rats by Adesua Emmanuel Ogunmokunwa, Babatunde Oluwaseun Ibitoye

“…Background: Monosodium glutamate (MSG) is a common food additive linked to various health concerns, including potential reproductive toxicity. Objective: To investigate the effects of chronic, low-dose MSG on testicular hormones and oxidative stress biomarkers in adult male Wistar rats. …”
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Liver Injury Secondary to Anti-TNF-Alpha Therapy in Inflammatory Bowel Disease: A Case Series and Review of the Literature by Ravish Parekh, Nirmal Kaur

“…All TNF-α inhibitors have been associated with liver toxicity, but many of these cases have been reported in patients receiving therapy for rheumatologic disease. …”
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Neuropsychological profiles of patients suffering from hallucinogen persisting perception disorder (HPPD): A comparative analysis with psychedelic-using and non-using controls by Georg Leistenschneider, Tomislav Majić, Simon Reiche, Thomas G. Riemer

“…Abstract Classic psychedelics like LSD and psilocybin are showing promising effects in treating certain psychiatric disorders. Despite their low toxicity and lack of an addictive potential, in some individuals, psychedelics can be associated with persisting psychological harms. …”
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Prevalence and Associated Factors of Malaria Infection among Outpatients Visiting Shewa Robit Health Center, Northcentral Ethiopia by Azene Tesfaye, Tadegew Teshome

“…Interestingly, 73.2% (n = 309) of the participant did not utilize LLINs due to the fear of toxicity (37.4%, n = 158), misconception (21.6%, n = 91), and shortage (14.2%, n = 60). …”
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Status of Soil Acidity under Different Land Use Types and Soil Depths: The Case of Hojje Watershed of Gomibora District, Hadiya Zone, Southern Ethiopia by Tesfaye Abure

“…In the humid regions of Ethiopia, soil productivity and fertility are significantly affected by soil acidity, which is connected to infertility and mineral toxicity. The study aimed to assess the status of soil acidity under different land use types and soil depths in Hojje watershed of Gomibora district, Hadiya Zone, Southern Ethiopia, in November 1, 2020. …”
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Mineral Element Contents in Commercially Valuable Fish Species in Spain by Ana Rivas, Luis Peña-Rivas, Eduardo Ortega, Concepción López-Martínez, Fátima Olea-Serrano, Maria Luisa Lorenzo

“…In conclusion, metal contents in the fish species analyzed are acceptable for human consumption from a nutritional and toxicity point of view.…”
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