Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases by Asako Otomo, Lei Pan, Shinji Hadano

“…It is currently believed that a complex interplay of multiple toxicity pathways is implicated in disease onset and progression. …”
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Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis by Davood Oliaee, Mohammad Taher Boroushaki, Naiime Oliaee, Ahmad Ghorbani

“…Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P<0.01). …”
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Environmental Impact of Limestone Mining Using A Life Cycle Assessment Method by Atfal Murodif, Anas Miftah Fauzi, Erizal, Lina Karlinasari

“…In conclusion, the research findings reveal environmental impact indicators with standardized values, such as Abiotic Depletion, Abiotic Depletion of Fossil Fuels, Acidification, Eutrophication of Freshwater Aquatic Ecotoxicity, Global Warming 100a, Human Toxicity, Marine Aquatic Ecotoxicity, Ozone Layer Depletion, Photochemical Oxidation, and Terrestrial Ecotoxicity.  …”
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Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives by Marco A. Luís, Marcelo A. D. Goes, Fátima Milhano Santos, Joana Mesquita, Paulo Tavares-Ratado, Cândida Teixeira Tomaz

“…However, despite advancements in gene manipulation tools and delivery systems, several challenges remain unresolved, including inefficient delivery, lack of sustained expression, immunogenicity, toxicity, capacity limitations, genomic integration risks, and limited tissue specificity. …”
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Interferon-gamma: A Potent Antiviral Agent Targeting Macrophages Infected with LP-BM5 Murine Leukemia Virus, the Causative Agent of 'AIDS' in Mice by Jens J Kort, Julie L Eiseman

“…Further, since a lower concentration of each agent was required for efficacy in combination therapy, toxicity associated with single agent therapy may be avoided.…”
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An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment by Banu Taskin, Mümin Alper Erdoğan, Gürkan Yiğittürk, Sibel Alper, Oytun Erbaş

“…Also, the eighteen liver toxicity model created rats were equally divided into two groups, one of which received digoxin 0.1 mg/kg/day digoxin (Group 1) and the other group (Group 2) was given saline (% 0.9NaCl) with a dose of 1 ml/kg/day for ten days. …”
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Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway by Pang Pengfei, Zhang Shirong

“…Cells were treated with curcumin only, dasatinib only, or the combination of curcumin and dasatinib for 24 hours. Cellular toxicity, cell proliferation, and cell death were determined by LDH, MTT, and trypan blue dye assays, respectively. …”
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In vitro characterization of beta-cyclodextrin liposomal formulation of cisplatin nanomedicine by Panijapatr Wasubhadtanasaka

“…By utilizing hydroxypropyl-β-cyclodextrin (BPCP) to increase drug hydrophilicity and liposomes for controlled release of cisplatin (CP), the hydroxypropyl-β-cyclodextrin-cisplatin liposomal formulation (BCDCPLP) demonstrated improved stability, targeted delivery, and reduced toxicity. The study confirmed that the above formulation had the highest cytotoxicity against HeLa cells, with significantly lower IC50 and IC90 values than cisplatin alone. …”
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Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy by Guodong Li, Shuangpeng Pu, Lisiyao You, Yuan Gao, Yuexia Zhong, Huadong Zhao, Dong Fan, Xiyan Lu

“…Recent studies have focused on engineering OMVs to enhance tumour-targeting capabilities, reduce toxicity, and extend circulation time in vivo. This article reviews the latest progress in OMV engineering for tumour treatment and discusses the challenges associated with the use of OMV-based antitumour therapy in clinical practice.…”
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Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches by Dong Li, Aixin Li, Hairui Zhou, Xi Wang, Peng Li, Sheng Bi, Yang Teng

“…Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.…”
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Physiochemical Studies of Sodium Chloride on Mungbean (Vigna radiata L. Wilczek) and Its Possible Recovery with Spermine and Gibberellic Acid by Srijita Ghosh, Sanglap Mitra, Atreyee Paul

“…Our study shows that low concentrations of either gibberellic acid or spermine will be able to overcome the toxic effects of NaCl stress in mungbean seedlings.…”
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Harnessing light-activated gallium porphyrins to combat intracellular Staphylococcus aureus using an in vitro keratinocyte infection model by Klaudia Szymczak, Michał Rychłowski, Lei Zhang, Joanna Nakonieczna

“…This study is the first to analyze aPDI toxicity in real time within an infection model, demonstrating that this method is neither cytotoxic nor phototoxic.…”
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Uranium phytoremediation by Helianthus annuus L. and Amaranthus caudatus L. plants by Majid Mahdieh, Mohammedreza Sangi, Saeid Hamidi, Seyed M. Talebi, Alex V. Matsyura

“…Uranium contamination presents significant challenges to biological systems due to its chemical toxicity and radiological impacts. Rhizofiltration emerges as a cost-effective strategy for environmental remediation of uranium. …”
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In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“… Inflammation is a crucial defense mechanism against toxic stimuli and physical traumas. This study aimed to design six new pyrazoline and pyrimidine derivatives and assess their potential anti-inflammatory activity by targeting the cyclooxygenase (COX) enzyme, a key mediator in the inflammation process. …”
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Assessing Risk of Fumonisin Contamination in Maize Using Near-Infrared Spectroscopy by Cecile Levasseur-Garcia, Sylviane Bailly, Didier Kleiber, Jean-Denis Bailly

“…Fumonisins are major mycotoxins found worldwide in maize and maize products. Because of their toxicity for both human and animals, European Union regulations were created to fix the maximal fumonisin B1 and B2 content allowed in foods and feeds. …”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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Anesthetic-Induced Oxidative Stress and Potential Protection by Cheng Wang, Xuan Zhang, Fang Liu, Merle G. Paule, William Slikker, Jr.

“…Prolonged exposure of developing mammals to general anesthetics affects the N-methyl-D-aspartate (NMDA)–type glutamate or γ-aminobutyric acid (GABA) receptor systems and enhances neuronal toxicity. Stimulation of immature neurons by NMDA antagonists or GABA agonists is thought to increase overall nervous system excitability and may contribute to abnormal neuronal cell death during development. …”
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New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites by George J. Kontoghiorghes

“…The ACMs from non-absorbed aspirin (about 30%) may also mitigate the toxicity of heme and nitroso-heme and other iron toxins from food, which are responsible for the cause of colorectal cancer. …”
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Exploring EPR Parameters of 187Re Complexes for Designing New MRI Probes: From the Gas Phase to Solution and a Model Protein Environment by Gustavo A. Andolpho, Elaine F. F. da Cunha, Teodorico C. Ramalho

“…In addition, thermodynamic analysis indicates that ReABT presents a higher stability and a lower toxicity than Gd-based CAs. The docking studies point out that ReABT interacts with amino acids residues of alanine, aspartate, and lysine from the PI3K active site. …”
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POTENTIAL RISKS ASSOCIATED WITH MISMANAGEMENT OF HOSPITAL WASTEWATER IN TANZANIA by Shadrack Mwita Sabai

“…Mismanagement of hospital wastewater pollutes soil, aquatic environments and spread infectious diseases that put public into health risks. Regardless on the toxicity of hospital wastewater, there are limited information on the impact of hospital wastewater mismanagement to the environment and surrounding community in the developing countries. …”
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