Hsp70 and Its Molecular Role in Nervous System Diseases by Giuseppina Turturici, Gabriella Sconzo, Fabiana Geraci

“…Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis). …”
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Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants by Franklyn Nonso Iheagwam, Solomon Oladapo Rotimi

“…Molecular docking, druglikeness, absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the best hits were further simulated. …”
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In Vitro Evaluation of the Cytotoxic Potential of Environmental Contaminant Mixtures Present in Water for Human Use by Israa J. Hakeem, Ngiste Amare

“…However, once the individual compounds’ respective mechanisms of action have been established, the toxicity caused by the mixtures can be qualitatively predicted.…”
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DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…Optimization of standard treatment protocols consisting of the main columns of chemo- and radiotherapy followed or preceded by surgical intervention is often limited by toxic side effects and induction of concomitant malignancies and/or development of resistant mechanisms. …”
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Dispelling stigma and enduring bias: exploring the perception of esports participation among young women by Di Tang, Bo Peng, Ruisi Ma, Kim-wai Raymond Sum

“…Additionally, thematic analysis was utilized to explore themes related to the experiences of female participation in HOK, societal perceptions of esports, gender biases, and online toxicity. The results indicate that HOK has successfully broadened female participation in esports through social media integration and esthetic appeal. …”
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Lentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement by Zhiqiang Zhang, Li Wang, Xia Ma, Hui Wang

“…Furthermore, LNT-PBAE-G-ND@OVA induced potent antibody response and showed no obvious toxicity in vitro and in vivo. Moreover, treatment with LNT-PBAE-G-ND@OVA was sufficient to alter the expression of genes associated with the cGAS-STING pathway, and the LNT-PBAE-G-ND@OVA induced upregulation of costimulatory molecules. …”
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Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice by Lubna Danish, Riffat Siddiq, Sarwat Jahan, Mehwish Taneez, Manzoor Khan, Marva Sandhu

“…Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. …”
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Foraging Activity and Trophic Spectrum of Red Ant Pogonomyrmex barbatus Smith, 1858, in Productivity-Contrasted Microenvironments by Rafael Guzmán-Mendoza, Gabriela Castaño-Meneses, José Alejandro Zavala-Hurtado

“…Foraging strategies can be influenced by many factors such as abundance, availability, and toxicity of the resources. In arid zones, the distribution and productivity of plants also act as additional factors that affect foraging strategies. …”
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Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis by Pinelopi Arvaniti, Kalliopi Zachou, George K. Koukoulis, George N. Dalekos

“…PIGCH is associated with many diseases, including drugs toxicity, viruses, and autoimmune liver diseases, with autoimmune hepatitis (AIH) being the most prevalent. …”
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Offshore wind energy: assessing trace element inputs and the risks for co-location of aquaculture by G. J. Watson, G. Banfield, S. C. L. Watson, N. J. Beaumont, A. Hodkin

“…However, a paucity of industry data makes it impossible to compare water and sediment TE concentrations at operational OWFs against toxicity thresholds, therefore, ecotoxicological risks are under assessed. …”
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Orally administered organophosphorus dimethoate mediated biochemical alterations in male and female experimental Rattus norvegicus (albino rats) by Nida Saleem, Mushtaq Hussain Lashari, Hafiz Ishfaq Ahmad

“…Abstract The main objective of the present study was to investigate the toxicity of orally administered organophosphorus dimethoate pesticide in Rattus norvegicus on the basis of biochemical alterations in the blood. …”
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Spray Dried Extract of Phormidium valderianum as a Promising Source of Natural Antioxidant by Dipan Chatterjee, Paramita Bhattacharjee, Gour Gopal Satpati, Ruma Pal

“…Therefore, this microencapsulated algal extract with minimum toxicity is a source of natural antioxidant and could have promising use as novel dietary supplement.…”
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Research Progress on Effects and Treatment of Microplastic Pollution in Freshwater Ecosystems by TANG Hongliang, MA Jinlong, XU Chenchen, PENG Songyao, FENG Lijuan

“…Due to their widespread distribution, being difficult to degrade, and toxic properties to organisms, they pose a serious threat to the health of freshwater ecosystems. …”
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Coverage bias in small molecule machine learning by Fleming Kretschmer, Jan Seipp, Marcus Ludwig, Gunnar W. Klau, Sebastian Böcker

“…Abstract Small molecule machine learning aims to predict chemical, biochemical, or biological properties from molecular structures, with applications such as toxicity prediction, ligand binding, and pharmacokinetics. …”
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Applying different techniques for evaluating the resistance to moisture of electrospun PVA nanofibers by Alessandro Estarque de Oliveira, Mônica Lopes Aguiar, Vádila Giovana Guerra

“… Poly (Vinyl Alcohol) (PVA) is used to produce nanofibers with electrospinning for several applications related to the non-toxicity of the material, however, the application in air filtration in hindered by the high hydrophilicity of the material, which requires the crosslinking with additives. …”
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Ultrasonography of the Kidneys in Healthy and Diseased Camels (Camelus dromedarius) by Mohamed Tharwat

“…Congestion, hemorrhage, hydronephrosis, acute glomerulonephritis, subacute glomerulonephritis, chronic glomerulonephritis, diffuse interstitial nephritis, focal interstitial nephritis, renal cyst, hyaline degeneration, renal amyloidosis, tubular nephrosis, pyelonephritis, hemosiderosis, and renal toxicity. When the kidney is examined by ultrasonography, the clinician can get sufficient information about the size, position, and echo patterns of the renal cortex and medulla and renal pelvis and outlines of the renal blood vessels. …”
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Cadmium Tolerance and Detoxification Mechanisms of <i>Lentinula edodes</i>: Physiology, Subcellular Distribution, and Chemical Forms by Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong

“…Enhanced antioxidant enzyme activities, reduced cadmium accumulation, and increased HAc-extractable cadmium with less toxicity promoted stronger cadmium tolerance and detoxification abilities in L130 compared to 1504. …”
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Anti-Müllerian Hormone as a Sensitive Marker of Ovarian Function in Young Cancer Survivors by Maryna Krawczuk-Rybak, Elzbieta Leszczynska, Marta Poznanska, Beata Zelazowska-Rutkowska, Jolanta Wysocka

“…We evaluated ovarian function by measuring the levels of anti-Müllerian hormone (AMH), estradiol, and gonadotropins in 83 young women treated for cancer during childhood and adolescence, and classified according to post-treatment gonadal toxicity versus 38 healthy females. Results. The mean AMH values were lower in the entire cohort independently of the risk group as compared to the control, whereas FSH was elevated only in the high risk group. …”
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Comprehensive Analysis of the Proteome of <i>S. cerevisiae</i> Wild-Type and <i>pdr</i>5Δ Cells in Response to Bisphenol A (BPA) Exposure by Valentina Rossio, Joao A. Paulo

“…We found that the ABC multidrug transporter Pdr5 plays an important role in protecting yeast cells from BPA toxicity, with its absence significantly sensitizing cells to BPA. …”
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Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment by Eleni Thodou, Maria Befani, George Triantafyllidis, Theodosia Choreftaki, George Kanellis, Nikolaos Giannakoulas

“…Salvage chemotherapy regimens were applied with poor results and severe toxicity. Total remission was achieved with monotherapy of brentuximab vedotin, a novel anti-CD30-targeted antibody drug conjugate. …”
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