Benchmarking of a time-saving and scalable protocol for the extraction of DNA from diverse viromes by Michael Shamash, Saniya Kapoor, Corinne F. Maurice

“…While the kit approach offers benefits like reduced toxicity and increased throughput, it has limitations such as higher costs and potential issues reliably capturing low-abundance taxa. …”
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Optimization and Thermodynamic Analysis of CO2 Refrigeration Cycle for Energy Efficiency and Environmental Control by Manish Hassani and Kamlesh Purohit

“…Carbon dioxide (R744) is recognized as a viable long-term refrigerant choice due to its favorable properties, including low Global Warming Potential, non-toxicity, non-flammability, affordability, and widespread availability. …”
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Occurrence of Surface Active Agents in the Environment by Ewa Olkowska, Marek Ruman, Żaneta Polkowska

“…Additionally, SAAs present in the environment can be accumulated in living organisms (bioaccumulation), what can have a negative effect on biotic elements of ecosystems (e.g., toxicity, disturbance of endocrine equilibrium). They also cause increaseing solubility of organic pollutants in aqueous phase, their migration, and accumulation in different environmental compartments. …”
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Mycoremediation of pesticide-contaminated soil: A review by Pujiati, Fatimah, Ramadhan Rico, Ni’matuzahroh

“…Pesticide contamination in soil presents significant environmental and health risks due to toxic residues. Traditional physical and chemical remediation methods are often expensive, ineffective at low concentrations, and generate toxic by-products. …”
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How Do MRI Findings Influence Rectal Cancer Management? by Ayloor Seshadri Ramakrishnan, Jeyakumar Pradeep

“…Treatment of rectal cancer is currently guided by the need to reduce local recurrence, improve survival, reduce treatment-related toxicity, and improve the patient's quality of life (QoL). …”
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In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae) by Johnson Nyarko Boampong

“…Selected organs were harvested for toxicity assessment. The anti-inflammatory and analgesic effect of the extract was determined in the carrageenan and thermal tail withdrawal tests, respectively. …”
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Investigation of Doxorubicin Efficiency in Some Hematological Parameters in Women with Breast Cancer in Iraq by Hanan B. Saadon

“…Doxorubicincontinues to be used in the management of breast cancer; nonetheless, its utilization is limited because of toxicity, including cardiotoxicity and myelosuppression. …”
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Single‐egg comet assay: A protocol to quantify DNA damage in natural bioarchives by Rejin Salimraj, Alessio Perotti, Marcin W. Wojewodzic, Dagmar Frisch

“…Abstract The comet assay (CA), originally developed as toxicity test, quantifies DNA integrity from DNA distribution across an electric field. …”
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Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications by Han Han, Erika M. Wolff, Gangning Liang

“…Future research is needed to address efficacy and potential toxicity issues before it can be implemented as a therapeutic strategy for solid tumors.…”
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Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia by Yonal Ipek, Dogru Hulya, Aktan Melih

“…All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al. (1993), Liu et al. (2000), and Cassinat et al. (2001)). ATRA-associated toxicity consisting of headache, fever, weakness, fatigue, dry skin, dermatitis, gastrointestinal disorders, and hypertriglyceridemia has been shown to be mild (Kurzrock et al. (1993)). …”
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PENGEMBANGAN BAHAN AJAR MATA KULIAH FISIOLOGI REPRODUKSI DI JURUSAN BIOLOGI UNIVERSITAS NEGERI MALANG by Farizha Irmawati, Umie Lestari, Hadi Suwono

“…The purpose of the research and development is to produce teaching materials such as textbooks supporting course in Reproduction Physiology research based on the toxicity analysis for students who take a course in Reproduction Physiology. …”
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Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters by Manuel Enrique Ávila-Blanco, Sandra Lizbeth Aguilera-Martínez, Javier Ventura-Juarez, Jorge Pérez-Serrano, Elizabeth Casillas-Casillas, Luis Fernando Barba-Gallardo

“…Propamidine isethionate is frequently used for AK treatment, in vivo study we are found IL-1β and IL-10 expression and caspase 3 activity is significantly increased with respect to the group that was inoculated with the amoeba without receiving any treatment, suggesting that it may be an effect of the toxicity of this drug on the corneal tissue. Application of the immunoconjugate showed enhanced amoebicidal and anti-inflammatory activities, with comparison to propamidine isethionate only. …”
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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma.…”
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A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations by Dervil Cody, Alan Casey, Izabela Naydenova, Emilia Mihaylova

“…Diacetone acrylamide exhibits a significantly lower toxicity profile in comparison to acrylamide at all exposure times. …”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. Additionally, the adaptation of these technologies has the potential to significantly reduce both the time and cost associated with obtaining safe drug approvals, all while adhering to the 3Rs principle (replacement, reduction, refinement). …”
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A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence. by Frédéric J Veyrier, Ivo G Boneca, Mathieu F Cellier, Muhamed-Kheir Taha

“…In Nm, Mn²⁺ export via MntX regulates the intracellular Mn/Fe ratio and protects against manganese toxicity that is exacerbated in low iron conditions. …”
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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. …”
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Bismuth Schiff base complex and its oxide nanoparticles as photocatalyst for the removal of dyes from water by Behrouz Shaabani, Shadi Soleimaninia

“…Abstract Bismuth oxide and bismuth complexes with organic ligands, particularly Schiff bases, have received much attention due to their non‐toxicity, antibacterial, and photocatalytic properties in removing water and environmental contaminants by oxidative degradation. …”
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Estimation of serum calcium levels in apheresis platelet donors by P. Arpitha, Ravindra Prasad Thokala

“…CONCLUSION: SDP collection is essentially a safe procedure with minimal adverse effects. Toxicity of citrate is not much pronounced. Recovery of calcium levels is within 30 min of completion of plateletpheresis.…”
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Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS by Zhifeng Guo, Ru Cai, Huidan Su, Yunlong Li

“…The alkaloids in the processed sample were less than those in the crude Rhizoma Corydalis significantly, while almost the corydaline has been changed in conformation after the sample had undergone processing, which provided support for the conclusion of reducing toxicity when the herbal medicine having been undergone a traditional drugs treatment process.…”
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