Proton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01) by Paul Lesueur, Benedicte Clarisse, Justine Lequesne, Idlir Licaj, Loic Feuvret, Dinu Stefan, Damien Ricard, Georges Noel, Jacques Balosso, Marie Lange, Aurelie Capel, Isabelle Durand-Zaleski, Marie Castera, Berenice Legrand, Nicolas Goliot, Camille Hedou, Jean Michel Grellard, Samuel Valable

“…Methods COG-PROTON-01 is the first worldwide randomized phase III prospective study evaluating long-term toxicity of these two irradiation modalities (PRT and XRT)for the treatment of cavernous sinus meningioma. …”
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Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice by Daniel Ampomah Frimpong, Aliu Moomin, Samuel Asare Nkansah, Aaron Opoku Antwi, Abubakar Ibn Sidik, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah

“…Results: VA at doses 0 – 300 mg/kg showed no toxicity in the mice, whereas VA at a dose of 3000 mg/kg resulted in the death of mice after 24 h. …”
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The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer by A. E. Glukhareva, G. V. Afonin, I. V. Kolobaev, L. Yu. Grivtsova, S. A. Ivanov, A.  D.  Kaprin

“…However, there is a cohort of patients who did not receive the planned amount of treatment, due to the high toxicity of simultaneous chemoradiotherapy. It is necessary to develop new approaches to concomitant therapy aimed at reducing the toxicity of the combined treatment and achieving maximum antitumor effect.…”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, patients with a high tumor burden do not benefit from additional LRRT, which inevitably results in toxicity. Recently, immunotherapy has made great progress in the treatment of recurrent or metastatic NPC (RM-NPC). …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Recently, the Italian Medicines Agency (AIFA) approved the possibility of switching between CDK4/6i for unacceptable toxicity. This study explores oncologists' experiences and future perspectives on CDK4/6 inhibitor switching following this new approval. …”
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Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study by Camille Windsor, Adrien Joseph, Stephanie Pons, Djamel Mokart, Frederic Pène, Achille Kouatchet, Alexandre Demoule, Fabrice Bruneel, Martine Nyunga, Edith Borcoman, Matthieu Legrand, Michael Darmon, Lara Zafrani, Elie Azoulay, Virginie Lemiale

“…Among chemotherapeutic agents, anthracyclines have been associated with cardiac toxicity. Like other chemotherapeutic agents, they may cause endothelial toxicity. …”
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Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…Our results illustrate the differences in physiology and behaviour that can arise when social contexts are manipulated and stress the importance of considering sociality when conducting toxicity tests with social organisms.…”
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Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity by Karine Andreau, Melanie Leroux, Aida Bouharrour

“…Activation or repression of the apoptotic process as an adaptative response to xenobiotics might lead to either acute or chronic toxicity. The purpose of this paper is to highlight the central role of oxidative stress induced by air pollutants and to focus on the subsequent cellular impacts ranging from cytoprotection to cytotoxicity by decreasing or stimulating apoptosis, respectively.…”
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A Serious Case of Poisoning Caused by Oral Ingestion of Water-Soluble Fertilizer by Wei Ye, Shirong Lin, Chengquan Zheng, Chunshui Cao

“…Acute kidney injury occurred early, which showed that the toxicity could not be ignored. It was necessary to seek medical attention as soon as possible. …”
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Effect of trace elements on the interface reactions between two lead-free solders and copper or nickel substrates by Soares D., Vilarinho C., Barbosa J., Samuel F., Trigo L., Bré P.

“…Traditional Sn-Pb solder alloys are being replaced, because of environmental and health concerns about lead toxicity. Among some alternative alloy systems, the Sn-Zn and Sn-Cu base alloy systems have been studied and reveal promising properties. …”
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Strategies in the Surgical Management of Atrial Fibrillation by Leanne Harling, Thanos Athanasiou, Hutan Ashrafian, Justin Nowell, Antonios Kourliouros

“…An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. …”
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Photodegradation of 2,4-Dichlorophenol in Aqueous Systems under Simulated and Natural Sunlight by Dorota Gryglik, Marta Gmurek, Magdalena Foszpańczyk, Stanisław Ledakowicz

“…The possibility of using natural sunlight to degrade 2,4-DCP in water in the middle latitudes was stated. The acute toxicity bioassay was conducted with the marine bacterium Vibrio fischeri as a bioluminescent indicator. …”
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Aluminum-Tolerant Pisolithus Ectomycorrhizas Confer Increased Growth, Mineral Nutrition, and Metal Tolerance to Eucalyptus in Acidic Mine Spoil by Louise Egerton-Warburton

“…Ectomycorrhizal fungi (ECM) may increase the tolerance of their host plants to Al toxicity by immobilizing Al in fungal tissues and/or improving plant mineral nutrition. …”
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Application of Bionanomaterials in Tumor Immune Microenvironment Therapy by Jiawei Wang, Yan Bao, Yandan Yao

“…However, the clinical utility of immunotherapy in cancer is limited by severe off-target toxicity, long processing time, limited efficacy, and extremely high cost. …”
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Nanomaterials in wound infeetion care for senile diabetes: current research and developments by Yiran Liu, Xue Bai, Hui Ren, Baofeng Guo

“…Wound infections in elderly diabetic patients represent a severe complication of diabetes, with diabetic foot ulcers being the most common manifestation.Due to impaired immune function and the prolonged course of the disease, elderly patients often struggle to control wound infections, leading to increased medical costs, extended hospital stays, higher rates of amputation and mortality.As bacterial resistance becomes more prevalent, traditional oral or intravenous antibiotics are increasingly ineffective in treating wound infections in elderly diabetic patients.In contrast, emerging nanomaterials offer promising prospects in antibacterial therapy, owing to their superior biocompatibility, targeted action, controlled release, and low toxicity.This article reviews the latest research on the antibacterial mechanisms of nanomaterials and explores their potential as a novel strategy for treating wound infections in elderly diabetic patients.…”
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Experimental Study of Irinotecan Induced Side Effects on Digestive and Immune System of Mice by Liya LIU, Thomas Joseph SFERRA, Senthilkumar SANKARARAMAN, Youqin CHEN

“…Body weight, diarrhea index, spleen index, thymus index, complete blood count and pathological changes of the jejunum, ileum and colon were measured on the second day and the fourth day after CPT-11 intervention.Results:Compared with the control group, mice body weight was decreased significantly on the second day and the fourth day upon CPT-11 intervention while diarrhea index was increased (<italic>P</italic>&lt;0.05); CPT-11 intervention also decreased spleen index, thymus index (<italic>P</italic>&lt;0.05), white blood cell count and neutrophil count profoundly along with significant jejunum, ileum and colon injury of the mice.Conclusion:CPT-11 can induce side effects about the digestive and immune system, which consistents with the clinical side effects of CPT-11, and this will be helpful for the further development of novel supplementary therapies for CPT-11 induced toxicity.…”
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Immunosuppressive therapy of patients with pemphigus with ineffectiveness of systemic corticosteroids by Vadim V. Chikin, Arfenya E. Karamova

“…Nevertheless, comparative studies show an increase in the effectiveness of therapy in patients with pemphigus and a faster achievement of therapeutic effect when prescribing cyclophosphamide, but not azathioprine, dapsone, methotrexate, mycophenolate mofetil or cyclosporine. However, the toxicity of cyclophosphamide limits its use in pemphigus. …”
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Effect of copper on some biochemical parameters in lambs by İsmail Şen, Ercan Keskin, Mahmut Ok, Hüdai İpek, Ramazan Çöl

“…No clinical symptoms were observed related lo copper toxicity or delraency In the groups II and III. respectively. …”
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Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health by Gerry Kurt Schwalfenberg

“…Vitamin K2 may be a useful adjunct for the treatment of osteoporosis, along with vitamin D and calcium, rivaling bisphosphonate therapy without toxicity. It may also significantly reduce morbidity and mortality in cardiovascular health by reducing vascular calcification. …”
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A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin by G. Rezaei Behbehani, L. Barzegar, M. Mohebbian, A. A. Saboury

“…The indexes of stability indicate that HSA removed Cu2+ from Aβ(1–16), rapidly, decreased Cu-induced aggregation of Aβ(1–16), and reduced the toxicity of Aβ(1–16) + Cu2+ significantly.…”
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