Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells by M. I. Doronin, D. A. Lozovoy, V. V. Pronin, D. V. Mikhalishin, V. A. Starikov, A. V. Borisov, A. A. Shishkova

“…Use of cell structures as test systems for assessing the toxicity of pharmacological substances instead of conventional tests on experimental animals allows us to better clarify the possible mechanism of the effect of the investigated substance. …”
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In vivo scanning laser fundus and high-resolution OCT imaging of retinal ganglion cell injury in a non-human primate model with an activatable fluorescent-labeled TAT peptide probe... by Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms

“…No evidence of pan-retinal toxicity or loss of retino-cortical function was detected in any of the three NHPs tested. …”
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Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Molecular Mechanics/Generalized Born Surface Area (MMGBSA) analysis validated their binding affinities by providing comparably lower binding free energies for orlistat (− 33.4743 ± 3.8908), acarbose (− 19.5455 ± 5.4702), and afatinib (− 36.4944 ± 5.4929) than the control, dasatinib (− 13.7785 ± 5.8058). Finally, toxicity analysis revealed orlistat and acarbose as the possible safer therapeutics by eliminating afatinib as it showed significant toxicity concerns. …”
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Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…In addition, the research includes preliminary phytochemical screening to identify key bioactive compounds and an acute toxicity test to assess the safety profile of the extract.…”
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Non-melanoma skin cancer treated with hypofractionated 192—Ir contact brachitherapy: a single institution series by Elisa Ciurlia, Bianca Santo, Maria Cristina Barba, Elisa Cavalera, Paola De Franco, Sara De Matteis, Giuseppe Di Paola, Angela Leone, Antonella Papaleo, Dino Rubini, Donatella Russo, Giuseppe Rubini, Angela Sardaro

“…Furthermore, the observed toxicity profile was favorable with no significant late toxicity.ConclusionsThese results suggest that c-HDR-BRT represents a viable therapeutic alternative for NMSC, combining high oncological efficacy with an acceptable safety profile, while minimizing the aesthetic and functional impact of therapy. …”
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The Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry by Mariela Guevara, Carla González de la Cruz, Fernanda Rodrigues-Soares, Ernesto Rodríguez, Caíque Manóchio, Eva Peñas-Lledó, Pedro Dorado, Adrián LLerena

“…The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10–40% of patients treated with fluoropyrimidines develop severe toxicity. …”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Yet, they raise concern with respect to toxicity and degradability issues. In that context, we have developed innovative bottom-up approaches towards ultrabright dye-based fluorescent organic nanoparticles (dFONs). …”
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Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis by Tingwei Zheng, Tingwei Zheng, Dandan Wang, Yuxin Miao, Yuxin Miao, Meng Dong, Qin Liu, Qin Liu, Qiuning Zhang, Huiling Bai, Huiling Bai, Hongtao Luo, Meixuan Li

“…The GRADE assessment yielded a low certainty of evidence.ConclusionsProton therapy offers a viable alternative treatment for patients with conjunctival malignancies, with acceptable treatment-related toxicity rates.…”
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Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity mechanism caused by them in recent years, has not been clearly explored. …”
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Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota by Xiao Han, Bingxin Huangfu, Tongxiao Xu, Kunlun Huang, Xiaoyun He

“…In the absence of significant toxicity and without affecting glucose tolerance, 50 and 100 μg/kg b. w. …”
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Assessment of Biological Activity, Total Phenolic Content, and Cytotoxicity of Ethyl Acetate Extracts from an Endophytic Fungus, Lasiodiplodia pseudotheobromae IBRL OS-64 by Mohd Taufiq Mat Jalil, Nurul Aili Zakaria, Mohd Fakharul Zaman Raja Yahya, Sharifah Aminah Syed Mohamad, Darah Ibrahim

“…Therefore, the present study suggests that the fraction extract could be an effective pharmaceutical agent and safe for drug development due to its low toxicity. …”
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Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Systemic uptake will be limited, likely resulting in less toxicity. The aim of the INTERACT MESO trial is to determine the maximum tolerable dose of intraperitoneal paclitaxel monotherapy in patients with MPM. …”
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Du macaque rhésus au macaque fascicularis : le refus de l’Inde de l’exportation de ses rhésus (1970-1990) by Laure Hoenen

“…The use of the rhesus monkey as an animal model in biomedical research during the 1950’s, principally for toxicity tests and polio vaccine production, fostered a dependence upon countries that exported these animals. …”
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History of the Organisation for Economic Co-operation and Development (OECD) test guidelines for non-animal test methods in Japan by Hajime Kojima

“…Drawing from this experience, I hope Japan will advance new approach methodologies for detecting systemic toxicity, which are in global demand.…”
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Transgenic Killer Commensal Bacteria as Mucosal Protectants by Luciano Polonelli

“…Unfortunately, current strategies for mucosal protection against candidiasis are severely limited by the lack of effective vaccines and the relative paucity and toxicity of commercially available antifungal drugs. …”
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Biosynthesis of Metal Nanoparticles: A Review by Narendra Kulkarni, Uday Muddapur

“…The limitation to the use of these nanoparticles is the paucity of an effective method of synthesis that will produce homogeneous size and shape nanoparticles as well as particles with limited or no toxicity to the human health and the environment. The biological method of nanoparticle synthesis is a relatively simple, cheap, and environmentally friendly method than the conventional chemical method of synthesis and thus gains an upper hand. …”
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Lead poisoning in ancient Rome by Francois P. Retief, Louise Cilliers

“…Although Roman writers commented on the toxicity of lead, classic chronic lead poisoning was first described only in the 7th century AD. …”
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Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus by Randah Dahlan, Ameen Patel, Shariq Haider

“…The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. …”
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Fungal- and Algal-Derived Synthesis of Various Nanoparticles and Their Applications by Anugrah Michael, Aniket Singh, Arpita Roy, Md. Rabiul Islam

“…Most traditional methods to generate nanoparticles have certain limitations, like the toxicity of precursor materials, the need for high-temperature management, and the high cost of synthesis, which ultimately hinders their utility in sectors. …”
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Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs by Li Fuquan, Singh Akhilesh Vikram

“…The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. …”
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