Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing by Colin T. Konishi, Nancy Mulaiese, Tanvi Butola, Qinkun Zhang, Dana Kagan, Qiaoyan Yang, Mariel Pressler, Brooke G. Dirvin, Orrin Devinsky, Jayeeta Basu, Chengzu Long

“…Using an inducible MUT NS-GFP neuron system, we identified early prevention of toxic protein expression allowed aggregate clearance, while late prevention halted further aggregation. …”
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Monitoring N : P Ratio and Cd, Cu, Pb, and Zn Contents in Different Types of Anaerobic Digestates: A Six-Year Study Case by Christina-Luise Roß, Kerstin Nielsen, Jorita Krieger, Marieke Hoffmann, Karen Sensel-Gunke, Frank Ellmer, Timo Kautz

“…Depending on the quality of the input substrates, process parameters, and postfermentation treatments, digestates may contain a broad spectrum of potentially toxic elements. We suspected that these contents may vary on a broad scale even under seemingly stable process conditions at the biogas plant. …”
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Performance enhancement of full inorganic Sb2S3 solar cells with MnS hole transport layers by Minghong Rui, Hangyu Li, Yuan Li, Wenqi Li, Sumei Wang

“…However, the issue of high cost, poor environmental stability and toxic benzene-based solvents for preparation represent significant challenges for the efficient organic HTLs. …”
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Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…This extensive use is reflected in a vast amount of this compound in the environment, which may cause toxic effects in organisms that come in contact with it. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. …”
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Health risks evaluation of mycotoxins in plant-based supplements marketed in Malaysia by Rozaini Abdullah, Nur Syazwin Kamarozaman, Siti Soleha Ab Dullah, Mohd Yusmaidie Aziz, Hussein Bakheit Adam Aziza

“…Abstract Mycotoxins are toxic secondary metabolites produced by fungi, pose significant health risks when present in plant-based supplements (PBS), necessitating thorough risk assessment to ensure consumer safety. …”
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Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100 by M. Yasmin Begum, Ali Alqahtani, Mohammed Ghazwani, Noura Abdullah Alhamood, Umme Hani, Avanthi Jajala, Mohamed Rahamathulla

“…Duloxetine HCl produces a toxic substance called alpha-naphthol when duloxetine HCl is in contact with gastric fluid. …”
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Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…The FDC should be taken without food by patients experiencing central nervous system toxicities.…”
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Review on Synthesis Method, Classification and AdsorptionSeparation and Sensing Application of Metal-Organic Frameworks (MOFs) Based Composites by Aklilu Melese, Kenaegzer Mulate, Abdu Hussen, Afework Hailekiros, Walelign Wubet

“…Because of these properties, MOFs composites can be used for a wide range of applications, including, sensing toxic chemicals, drugs, gases, and trace metals, components of foods and many more and also for detection of different materials. …”
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PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…Thirty-three patients received BPX-601 with or without rimiducid, 24 patients with mPDAC and 9 with mCRPC. Two dose-limiting toxicities and two treatment-related deaths occurred in the highest-dose mCRPC cohort, after which the study was terminated, without determination of the RP2D. …”
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Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon‐Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous... by Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu

“…This process is driven by the superoxide radicals, holes and hydroxyl radicals produced by C‐TiO2/SiNPs under visible light irradiation. The total toxicities obviously reduce after OTC is degraded by C‐TiO2/SiNPs. …”
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Investigation of children's toys quality on the Macedonian market: determination of lead, cadmium and chromium levels by Mirvete Abdullahi1, Suzana Angelova, Evgenija Kiroska Petreska, Tatjana Kadifkova Panovska

“…Lead in children's toys originates from toxic lead dyes and can lead to serious health complications of central nervous system, cardiovascular, immune system and kidneys. …”
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Tailored biomimetic nanoreactor improves glioma chemodynamic treatment via triple glutathione depletion and prompt acidity elevation by Ya Wen, Qiansai Qiu, Feng Feng, Yujuan Zhu, Jianquan Zhang, Zesheng Sun, Tuodi Zhang, Wei Shi, Jinlong Shi

“…Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous H2O2 into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy because of OH scavenging and decreased OH production efficiency. …”
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The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells by Thai Hien Tu, Fatima Ezzahra Bennani, Nasser Masroori, Chen Liu, Atena Nemati, Nicholas Rozza, Amichai Meir Grunbaum, Richard Kremer, Catalin Milhalcioiu, Denis-Claude Roy, Christopher E. Rudd

“…Abstract Severe COVID-19 can trigger a cytokine storm, leading to acute respiratory distress syndrome (ARDS) with similarities to superantigen-induced toxic shock syndrome. An outstanding question is whether SARS-CoV-2 protein sequences can directly induce inflammatory responses. …”
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Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing by Marko Demenj, Martina Žabčić, Marija Vukomanović, Tatjana Ilić-Tomić, Dušan Milivojević, Simonida Tomić, Dubravka Živanović, Marija M. Babić Radić

“…No mortality was detected among the <i>Caenorhabditis elegans</i> throughout the incubation period, indicating that the scaffolds are not toxic. The results of in vitro release study of allantoin, quercetin, and caffeic acid confirm the scaffolds’ significant potential for simultaneous release. …”
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The abundance of microplastics in coral reef ecosystems in the waters of Krueng Raya, Aceh Besar by Ulfah Maria, Juliani Rika, Agustina Sri, Purnawan Syahrul, Malayana Intan, Muliari, Miswari Nur, Yusrizal, Irfannur

“…Microplastics have the potential to disrupt the balance of marine ecosystems due to their non-degradable and toxic nature to organisms. This study aims to analyze the abundance and types of microplastics in sediment from coral reef ecosystems at three locations in Krueng Raya waters (Inong Bale, Ahmad Rhang Manyang, and Lhok Mee) and evaluate the correlation between microplastic abundance and live coral conditions. …”
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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy by Yujia Liang, Shufang Ning, Mekhrdod S. Kurboniyon, Khaiyom Rahmonov, Zhengmin Cai, Shirong Li, Jinling Mai, Xiaojing He, Lijuan Liu, Liping Tang, Litu Zhang, Chen Wang

“…In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. …”
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Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation by Bradley A. Wall, Daniel A. Galvão, Naeem Fatehee, Dennis R. Taaffe, Nigel Spry, David Joseph, Robert U. Newton

“…To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities. Methods. One hundred and seven men (42–89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis. …”
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Evaluation of Bioactive Compounds and Chemical Elements in Herbs: Effectiveness of Choline Chloride-Based Deep Eutectic Solvents in Ultrasound-Assisted Extraction by Aleksandra Szydłowska-Czerniak, Agnieszka Kowaluk, Michał Strzelec, Tomasz Sawicki, Małgorzata Tańska

“…Additionally, macroelements (K, Na, Ca, Mg), micronutrients (Mn, Zn, Fe, Cu), and a toxic element (Cd) in four herbs were analyzed using inductively coupled plasma–mass spectrometry (ICP–MS). …”
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