Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico by Mario G. Ortiz-Martínez, Rosa I. Rodríguez-Cotto, Mónica A. Ortiz-Rivera, Cedric W. Pluguez-Turull, Braulio D. Jiménez-Vélez

“…Urban extracts were highly toxic, proinflammatory (IL-6/IL-8 secretion), and induced higher TLR4 expression and NF-κB activation compared to rural extracts. …”
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Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract by Faaiza Naaz K, Alavya Tiwari, Aabid Hussain Shaik, Indumathi P, Brianna Brianna, Ayaz Anwar, Mohammed Rehaan Chandan

“…The results demonstrated that ZnO nanoparticles were non-toxic to the normal cell line. At a concentration of 7.82 μg/mL, there was a 15.4% decrease in cell viability relative to the control in HCT116 cell lines, indicating cytotoxicity. …”
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Customizing the optical, electronic and transport attributes of lead-free hybrid FASnBr3 perovskites triggered by spin-orbit coupling and strains by Nusrat Jahan, Farah B.H. Pritu, Md Rasidul Islam, Budrun Neher, M Mahbubur Rahman, Farid Ahmed

“…However, the commonly studied MAPbI3 and FAPbI3 are toxic and less stable, prompting the necessity for safer replacements. …”
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Photocatalytic treatment of coking wastewater by cerium oxide loading with nitrogen-doping co-modified graphite carbon nitride by AN Ning, HAO Yuying, HU Shaowei, CHEN Peng, WANG Fei, WANG Yong, LIU Fang, LI Hanfei

“…Coking wastewater contains over 500 species toxic substances, and is recognized as the most intractable treated wastewater. …”
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OsHMA3 overexpression works more efficiently in generating low-Cd rice grain than OsNramp5 knockout mutation by Yuejing Gui, Joanne Teo, Dongsheng Tian, Raji Mohan, Zhongchao Yin

“…Abstract Objective Cadmium (Cd) is a highly toxic metal element and a carcinogen to humans. Rice is prone to taking up Cd from paddy fields and accumulating it in grain, which raises health concerns for rice consumers. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Introduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. …”
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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis by Adriana Bezerra-Souza, Jéssica A. Jesus, Márcia D. Laurenti, Aikaterini Lalatsa, Dolores R. Serrano, Luiz Felipe D. Passero

“…Increased steady-state flux was reported for nanoenabled butenafine formulations with reduced lag time in Franz cell diffusion assays across Strat-M membranes. No toxic or inflammatory reactions were detected in animals treated with BUT-SNEDDS, BUT-SNEDDS gel, or butenafine. …”
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A review on bioremediation by microbial immobilization-an effective alternative for wastewater treatment by Frank Abimbola Ogundolie, Olorunfemi Oyewole Babalola, Charles Oluwaseun Adetunji, Christiana Eleojo Aruwa, Jacqueline Njikam Manjia, Taoheed Kolawole Muftaudeen

“…Furthermore, our work stands out by highlighting emerging state-of-the-art tools that are bioinspired [enzymes, reactive permeable barriers linked to electrokinetic, magnetic cross-linked enzyme aggregates (CLEAs), bio-coated films, microbiocenosis], as well as the use of nanosized biochar and engineered cells or their bioproducts targeted at enhancing the removal efficiency of metals, carbonates, organic matter, and other toxicants and pollutants. The potential integration of 'omics' technologies for enhancing and revealing new insights into bioremediation via cell immobilization is also discussed.…”
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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Treatment was well tolerated, and no dose-limiting toxicities were observed. The most frequent adverse events were fever (40%), fatigue (40%) and nausea (40%). …”
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Evaluating the Effect of Chloroform and Water Extract of Satureja khuzistanica on the Expression of Bcl-2 and Bax in Gastric Cancer Cell Line by Bagher Biglak, Asghar Tanomand, Leyla Açik, Farzad Arjomandi Rad, Gholamreza Shahsavari, Saman Kazemi, Hossein Soltanzadeh

“…Natural antioxidant sources without toxic side effects are suitable for the treatment and management of diseases such as cancer. …”
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Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease by Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han, Zhentao Zhang, Zhaohui Zhang, Yingjie Zhu, Zuxin Chen, Xifei Yang, Keqiang Ye

“…Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY‐box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6+/ALDH1A1+) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT‐rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT‐rich DNA sequences, and toxic dopamine metabolite accumulation. AEP cuts Sox6 and ALDH1A1 in dopaminergic neurons that project to the locus coeruleus (LC), abolishing Sox6's transcriptive and ALDH1A1's enzymatic activities. …”
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Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…These changes are associated with impaired synaptic development, reduced neuronal connectivity, and enhanced cellular stress responses, including the increased formation of stress granules, markers of apoptosis and autophagy, and the presence of intracellular toxic tau aggregates. This study highlights the value of retinal models derived from human induced pluripotent stem cells in exploring the mechanisms underlying retinal pathology associated with tau mutations. …”
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Biochar in the Remediation of Organic Pollutants in Water: A Review of Polycyclic Aromatic Hydrocarbon and Pesticide Removal by Jelena Beljin, Nina Đukanović, Jasmina Anojčić, Tajana Simetić, Tamara Apostolović, Sanja Mutić, Snežana Maletić

“…High surface area (up to 1500 m²/g), porosity, and modifiable surface functional groups make biochar effective in adsorbing a wide range of contaminants, including toxic metals, organic pollutants, and nutrients. …”
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High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs... by Zifang Peng, Shijiao Hou, Qingyun He, Fangcheng Su, Lishun Ren, Congcong Pei, Dan Yin, Yanhao Zhang, Yanjie Huang, Shusheng Zhang, Zongwei Cai

“…Current study builds the relationship between pollution status of such novel pollutants and human activities, and possibly guides people in central China to take precautions to protect themselves from environmental toxicants at special daily time.…”
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Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment by Fangling Li, Chengjing Liu, Wenyi Gu, Qianhe Xu, Dongmei Li, Dongdong Cao, Zhiyong Liu

“…However, GCV has non-specific action and toxic side effects in vivo, and how to make it safer and more effective against KSHV is still a great challenge. …”
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Less cytotoxic phthalocyanine derivative promotes in vitro wound healing compared to chlorhexidine by Caique Andrade Santos, Adriano de Souza Pessoa, Fabiano Vieira Vilhena, Rodrigo Cardoso de Oliveira, Paulo Sérgio da Silva Santos, Carla Andreotti Damante, Mariana Schutzer Ragghianti Zangrando

“…In a comparative analysis, PHY showed less cytotoxicity than CHX and PHY concentrations of 0.0075% and 0.015% was non-toxic even after 48 h of contact with the cells. …”
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Towards the Sustainable Removal of Heavy Metals from Wastewater Using <i>Arthrospira platensis</i>: A Laboratory-Scale Approach in the Context of a Green Circular Economy by Lamprini Malletzidou, Eleni Kyratzopoulou, Nikoletta Kyzaki, Evangelos Nerantzis, Nikolaos A. Kazakis

“…The use of living <i>Arthrospira platensis</i> (<i>A. platensis</i>) cultures emerges as a promising green solution for the bioremediation of water contaminated by toxic metal waste. The scope of the present study is to evaluate the microalga’s potential in heavy metal remediation, in the case of multi-metal-treated (multi-MT) systems. …”
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Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy by Jay Chadokiya, Kai Chang, Saurabh Sharma, Jack Hu, Jennie R. Lill, Jennifer Dionne, Jennifer Dionne, Jennifer Dionne, Amanda Kirane

“…Standard therapy generally applies a “one size fits all” approach, which not only provides ineffective or limited responses, but also an increased risk of off-target toxicities and acceleration of resistance mechanisms or adverse effects. …”
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Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats by Lili He, Qingjuan Zuo, Sai Ma, Guorui Zhang, Zhongli Wang, Tingting Zhang, Jianlong Zhai, Yifang Guo

“…This study employed 16S rRNA sequencing technology and liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based metabolic profiling combined with advanced differential and association analyses to investigate the correlation between the microbiome and the metabolome in male DSS rats.Results A high-salt diet disrupted the balance of the intestinal flora and increased toxic metabolites (methyhistidines, creatinine, homocitrulline, and indoxyl sulfate), resulting in severe kidney damage. …”
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The use of nano-structured cellulose to improve plywood: A review by L.C. Lirya Silva, F.O. Lima, S.N. Monteiro, A.R.G. Azevedo, A.L. Christoforo, B.S. Ferreira, D. Goveia, C.I. de Campos

“…Therefore, using nanofibers and cellulose nanocrystals can be considered sustainable alternatives for the wood-based panel industry, improving the mechanical properties and reducing toxic emissions.…”
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