Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 by Chuangjiang Chen, Chenlong Wang, Hui Jiang, Mengya Wang, Sajid Ur Rahman, Changjiang Chen, Hongyan Ding, Chang Zhao, Wanyue Huang, Xichun Wang

“…Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. …”
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RETRACTED ARTICLE: Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications by Reza Eivazzadeh-Keihan, Zahra Sadat, Hooman Aghamirza Moghim Aliabadi, Fatemeh Ganjali, Amir Kashtiaray, Milad Salimi Bani, Samira Komijani, Mohammad Mahdi Ahadian, Nabi salehpour, Reza Ahangari Cohan, Ali Maleki

“…Moreover, the synthesized SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposite does not demonstrate toxicity toward HEK293T normal cell line after 48 and 72 h. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…They improve the solubility and stability of PROTACs, allow for targeted delivery to the tumour site and minimize toxicity to healthy cells. Moreover, arguably the most interesting virtue of PROTACs is its applicability for RNA viral infections (new vaccine design) based on the degradation of viral proteins. …”
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GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma by Yi Sun, Enze Li, Wenzhao Zhong, Zhaoming Deng, Ziyao Zhou, Ka Hong Wong, Xiangwei Li

“…The study demonstrates that PC@B-H achieves a 92.3 % tumor growth inhibition rate with minimal systemic toxicity, offering a promising avenue for enhancing the efficacy of OSCC treatment through combined cell death pathways and immune activation.…”
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Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity by Areej I. Alhazmi, Mohamed F. El-Refaei, Eman A. A. Abdallah

“…Gallic acid has a protective role against kidney dysfunction and renal damage in Ni-nanoparticle toxicity.…”
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Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Isaac A. Adedara, Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, Ebenezer O. Farombi

“…2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…Our findings illuminate the personalized nature of corona formation under a dynamic inflammatory condition and its impact on NP-mediated immune activation profiles and inflammation, suggesting that disease progression-related alterations in plasma composition can manifest in the corona to cause unintended toxicity and altered therapeutic efficacy.…”
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Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement by Ashiq Ali, Aisha Khatoon, Muhammad Kashif Saleemi, Rao Zahid Abbas, Bilal Murtaza, Kaynaat Akbar, Qaisar Tanveer, Sami Ullah Khan Bahadur, Hissah Abdulrahman Alodaini, Mai Ahmad Alghamdi

“…The study highlights Pichia kudriavzevii as a promising agent for mitigating aflatoxin-induced toxicity in broiler chicks by improving antioxidant and immunomodulatory status, normalizing biomarkers, and reversing pathological alterations through multifaceted protective mechanisms.…”
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mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

“…When combined with cisplatin, everolimus notably enhances the therapeutic efficacy without increasing the toxicity typically associated with platinum-based drugs. …”
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Comparison of clinico-pathological characteristics and survival of recurrent ovarian cancer patients on seven different chemo-protocols by Sattar Saima, Ahmad Mobasher, Saeed Hamid, Saleem Zikria, Danish Zeeshan, Akhlaq Muhammad

“…These data suggest that CP regimen exhibited improved clinical efficacy and decreased toxicity related non-compliance in recurrent ovarian cancer patients of Lahore.…”
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Modeling the endocrine control of vitellogenin production in female rainbow trout by Kaitlin Sundling, Gheorghe Craciun, Irvin Schultz, Sharon Hook, James Nagler, Tim Cavileer, Joseph Verducci, Yushi Liu, Jonghan Kim, William Hayton

“…We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk.…”
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A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke by Ke Xu, Bowen Deng, Tongtong Jia, Mihong Ren, Hai Chen, Jing Zhang, Jinlin Guo, Yong Li, Jian Wang

“…The active components of BC exert neuroprotective effects by reducing microcirculation disturbance, excitatory amino acid toxicity, and oxidative stress injury in the acute stage; inhibiting inflammatory injury, apoptosis, and blood-brain barrier (BBB) disruption in the subacute stage; and promoting angiogenesis and neurogenesis in the restoration stage. …”
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Protective Effect of Liposome-Encapsulated Glutathione in a Human Epidermal Model Exposed to a Mustard Gas Analog by Victor Paromov, Sudha Kumari, Marianne Brannon, Naga S. Kanaparthy, Hongsong Yang, Milton G. Smith, William L. Stone

“…This study provides a rationale for use of antioxidant liposomes against HD toxicity in the skin considering further verification in animal models exposed to HD.…”
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Evolution of the Radiation Shielding, Optical, and Luminescence Properties of PbO₂-SiO₂ Glass Systems and the Influence of Rare Earth Elements (Eu, Ce, Yb) by Mioara Zagrai, Ramona-Crina Suciu, Radu Cristian Gavrea, Vasile Rednic

“…Traditional radiation shielding materials, like lead and concrete, face challenges due to toxicity and weight. Glass materials provide an alternative, offering transparency and efficiency. …”
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Heptamethine cyanine-based polymeric nanoparticles for photothermal therapy in HCT116 human colon cancer model by Sastiya Kampaengsri, Gong Yi Yong, Sirimongkon Aryamueang, Bongkot Ouengwanarat, Thitima Pewklang, Kantapat Chansaenpak, Sarawut Jitrapakdee, Chin-Siang Kue, Anyanee Kamkaew

“…Finally, the nanoparticles’ acute toxicity and effectiveness were assessed using the chick embryo model. …”
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Cytotoxic evaluation of a mixture of four commonly used pesticides on mammalian cell lines by Prudence Agnandji, Eugène S. Attakpa, Fabrice Cazier

“…The cytotoxicity was compared to a quantitative structure-activity relationship for baseline toxicity, and chemicals were confirmed as baseline toxicants in this cell line. …”
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Fatal intoxication after oral ingestion of amphetamine: Two case reports by Evelyn Pawlik, Felix Mayer, Oliver Temme

“…The amphetamine concentrations of both cases are compared and the distribution in the body is discussed. The toxicity of the amphetamine by-products on the human body remains unclear and is subject of further studies.…”
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Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies by Chau Yee Ng, Chun-Bing Chen, Ming-Ying Wu, Jennifer Wu, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Ya-Ching Chang, Chun-Wei Lu

“…Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). …”
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Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration by Nitchaphat Khansakorn, Waranya Wongwit, Prapin Tharnpoophasiam, Bunlue Hengprasith, Lerson Suwannathon, Suwannee Chanprasertyothin, Thunyachai Sura, Sming Kaojarern, Piyamit Sritara, Jintana Sirivarasai

“…This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.…”
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Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome by Marta Vázquez, Cecilia Maldonado, Natalia Guevara, Andrea Rey, Pietro Fagiolino, Antonella Carozzi, Carlos Azambuja

“…As this reactive metabolite is detoxified mainly by enzymatic reactions, involving microsomal epoxide hydrolase and/or GSH-S-transferases and these enzymes are polymorphically expressed in humans, arene oxide toxicity is increased when epoxide hydrolase or GSH-S-transferases is either defective or inhibited or a depletion of intracellular glutathione levels is taking place. …”
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