Novel Application for Activated Carbon Pharmaceutical Formulation as an Efficient Adsorbent of Iron (III) from Contaminated Canned Food by Zahrah T. Althagafi, Hassan A. Arida, Reham F. Hassan

“…These application studies realize the applicability of utilizing active carbon commercially available in pharmaceutical stores to eliminate the toxicity of canned food contaminated by high levels of the investigated elements.…”
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Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska Karolina, Gunia-Krzyżak Agnieszka, Koczurkiewicz Paulina, Wójcik-Pszczoła Katarzyna, Żelaszczyk Dorota, Popiół Justyna, Pękala Elżbieta

“…Rapid biotransformation reduces exposure to the maternal compound and may lead to the generation of active, non-active or toxic metabolites. In contrast, high metabolic stability may promote interactions between drugs and lead to parent compound toxicity. …”
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Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2 by Qibing Gu, Xiayu Zhu, Jiale Ma, Tao Jiang, Zihao Pan, Huochun Yao

“…We constructed a mutant strain, ΔparDE, to explore its functions in bacterial virulence, various stress responses, and biofilm formation capabilities. The toxicity exerted by the toxin ParE can be neutralized by the antitoxin ParD. …”
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Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model by Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda

“…Because hOCT2 is responsible for the development of adverse effects caused by platinum-based anti-cancer agents, drugs with OCT2 inhibitory effects may serve as prophylactic agents against the toxicity of platinum-based anti-cancer agents. In the present study, we established a machine learning-based quantitative structure–activity relationship (QSAR) model for hOCT2 inhibitors based on the public ChEMBL database and explored novel hOCT2 inhibitors among the FDA-approved drugs. …”
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Tackling somatic DNA contamination in sperm epigenetic studies by Anamika Kumari, Anamika Kumari, Rajender Singh, Rajender Singh

“…IntroductionRecent interest in sperm epigenetics has stemmed from its implication in sperm DNA quality, sperm fertility, environmental toxicity, and transgenerational inheritance. Sperm epigenetic data may be significantly affected by somatic DNA contamination, resulting in misleading conclusions. …”
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Malathion-Induced Hematoxicity and Its Recovery Pattern in Barbonymus gonionotus by Cynthia E. Mrong, Md. R. Islam, Kamrunnaher Kole, Nusrat N. Neepa, Md. J. Alam, Md. R. Haque, Umme O. Rahman, Golam M. Mostakim

“…The study thus confirms that hematology is a sensitive indicator for fish to detect toxicity caused by different chemicals. Changes in these parameters can provide useful information about environmental conditions and risk assessment of aquatic organisms.…”
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Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil by Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil

“…This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications.…”
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Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI by Tamara Salman Mohammed, Raya Ezat Maroof, Ali Hussein Al-Hafidh

“…The study showed that the levels of urea, creatinine, GPT, and GOT were either normal or slightly elevated and they are non-significantly associated with RA disease activity, the little effect of RA on kidney and liver may be related to the low doses of methotrexate and corticosteroid therapy which used mostly for these patients and didn’t reach to toxicity. …”
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Discovery of Anti-inflammatory Peptides from Channa argus Using Virtual Screening, Molecular Docking, and Cell Model by XIANG Huan, LU Meiming, CHEN Shengjun, HUANG Hui, HU Xiao, ZHAO Yongqiang, WEI Ya

“…The results showed that 109 bioactive peptides obtained with papain were not toxic, from which 34 highly water-soluble peptides were selected for analysis of adsorption, distribution, metabolism, excretion and toxicity (ADMET) properties. …”
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The effect of different anesthetics on the incidence of AKI and AKD after neurosurgical procedures. by Vedran Premuzic, Vasilije Stambolija, Marin Lozic, Josip Kovacevic, Vladimir Prelevic, Marina Peklic, Miroslav Scap, Ante Sekulic, Nikolina Basic-Jukic, Slobodan Mihaljevic, Kianoush B Kashani

“…Patients treated with balanced anesthesia with sevoflurane had more frequent AKI and AKD with shorter survival. Renal toxicity of sevoflurane is pronounced in hypotension during operation and with a history of diabetes and coronary disease.…”
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Determination of Selected Metals in Fruit Wines by Spectroscopic Techniques by Justyna Płotka-Wasylka, Małgorzata Rutkowska, Bartłomiej Cieślik, Alan Tyburcy, Jacek Namieśnik

“…The determination of metals in different types of food and beverages samples has drawn significant attention due to several reasons with the most important one being the nutritional and toxic effects of these elements or their compounds. …”
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Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in differen... by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Animal experiments have substantiated the in vivo anticancer properties of Pt NCs, while also revealing their lower toxicity on cells and tissues. Pt NCs possess the ability to impede cell proliferation by inducing DNA damage and arresting the cell cycle in the G1 phase and possess the ability to promote BAX/Bcl-2/Caspase-3/mitochondrial apoptosis. …”
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Potential cervical anticancer activity of tomcat beetle (Paederus fuscipes) compounds against estrogen alpha receptor (3ert): In silico study by Latifa Nadya, Rais Ichwan Ridwan, Prasasti Dian, Utami Dwi

“…Data were analyzed by comparing bond energy, type of bond, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity). The results obtained were the bond energies of tamoxifen -10.68 kcal/mol, genistein -7.87 kcal/mol, pederin -7.57 kcal/mol, pseudopederin -8.07 kcal/mol, and pederone -7.83 kcal/mol. …”
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Optogenetic regulation of endogenous gene transcription in mammals by E. S. Omelina, A. V. Pindyurin

“…Although there are drug-inducible systems for transcriptional regulation of endogenous genes, optogenetic approaches seem to be the most promising for the gene therapy applications, as they are noninvasive and do not exhibit toxicity in comparison with druginducible systems. …”
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Effects of microplastics on microbial community and greenhouse gas emission in soil: A critical review by Guanlin Chen, Saisai Guo, Linan Liu, Wenzhu Zhang, Jingchun Tang

“…Additionally, MPs change rhizosphere microbial growth, cause soil nutrient loss, and induce plant toxicity, indirectly affecting GHG emissions. Finally, this article suggests strengthening research on rhizosphere and MPs surface microbial communities, exploring interactions with clay and minerals, and investigating GHG emission mechanisms to understand the ecological effects of MPs.…”
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Bioremediation of Polycyclic Aromatic Hydrocarbon contaminated Aqueous-Soil matrix: Effect of co-contamination by CN Owabor, OC Onwuemene, I Enaburekhan

“…@JASEM Keywords: Relative toxicity, Mineralization, Availability, Co-contamination, Activity series, Complexation J. …”
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Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin by Mariam Abdullah, Fazliny Abd. Rahman, Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Noor Hayaty Abu Kasim, Sabri Musa

“…Therefore, it is vital to have a continuous epidemiological dataset for a better understanding of Pb2+ toxicity. In the present study, we have exposed stem cells isolated from deciduous and permanent teeth, periodontal ligament, and bone marrow to five different types of Pb2+ concentrations (160, 80, 40, 20, and 10 µM) for 24 hours to identify the adverse effects of Pb2+ on the proliferation, differentiation, and gene expression on these cell lines. …”
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Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer by Ruohong Lin, Jiaxing Cheng, Jinlong Zhao, Liang Zhou, Jian Li, Xinchun Yang

“…Results The combination therapy not only demonstrated significantly inhibited tumor growth in a dose-dependent manner, but also seems to reduce the common toxicity associated with such treatments, as shown by the maintenance of body weights in the treated mice. …”
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Features of albendazole determination and dynamics of its decomposition in biological material by V.K. Shormanov, D.P. Shcherbakov, S.Yu. Garmonov

“…Along with pronounced pharmacological action, this compound is toxic to humans. Cases of poisoning with this substance and other benzimidazole derivatives are not uncommon. …”
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Oxide-Based Nanocomposites for Food Packaging Application: A Review by Aisha Idris Ali, Munir Abba Dandago, Fatima Idris Ali, Genitha Immanuel, Jishnu Naskar

“…Nanoparticles migration from packaging, on the other hand, is a source of concern due to their potential toxicity in the human body and the environment. The purpose of this article therefore, was to review the available literature on the utilization of metal oxide-based nanoparticles to produce nanocomposites for food packaging application. …”
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