Preclinical Evaluation of a Bone-Marrow Autograft Culture Procedure for Generating Lymphokine-Activated Killer Cells in Vitro by Hans-Georg Klingemann, Heather Deal, Dianne Reid, Connie J Eaves

“…Further augmentation of pretransplant chemotherapy causes life threatening toxicity to nonhematopoietic tissues and the effectiveness of currently available ex vivo purging methods in reducing the relapse rate is unclear. …”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…An overview of HIF-1-related drugs that are approved or in clinical trials is summarized, highlighting their potential capacity for targeting HIF-1 in cancer and cardiovascular toxicity related to cancer treatment. The review provides a comprehensive insight into HIF-1’s regulatory mechanism and paves the way for future research and therapeutic development.…”
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Effect of oxidizing agents on the treatment of a Colombian lead ore by alternative hydrometallurgical processes by Borda J., Salamanca I.D., Torres R.

“…The metallurgy of lead presents significant environmental and public health challenges due to its toxicity. This is why it has been necessary to develop hydrometallurgical processes as alternatives for obtaining metal with a more sustainable and environmentally safe approach. …”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…Further studies need to address on aspects like exact mechanisms, solution of detection obstacles, balance of practical usage and harmful effects such as potential flavor damage and toxicity in food, to gain a comprehensive understanding of antiglycation activities of tea polyphenols and its actual application.…”
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Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes by Liqiao Li, Haoxuan Chen, Yifang Zhu, Airi Harui, Michael D. Roth

“…Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A ventilated artificial lung model was developed to replicate the ventilatory and environmental features of the human lung and study their impact on the characteristics of inhaled e-cig aerosols from simulated vaping scenarios. …”
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Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B by Athika Rampadarath, Fatai Oladunni Balogun, Charlene Pillay, Saheed Sabiu

“…The lack of clinically approved PTP1B inhibitors has continued to prompt research in plant-derived therapeutics possibly due to their relatively lesser toxicity profiles. Flavonoid C-glycosides are one of the plant-derived metabolites gaining increased relevance as antidiabetic agents, but their possible mechanism of action remains largely unknown. …”
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Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review by Nkoana I. Mongalo, Maropeng V. Raletsena

“…A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on <i>P. africanum</i>, using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others. Further data was obtained from several scholarly theses, dissertations, and books on general plant sciences, ethnomedicine, and other pertinent ethnobotanical topics. …”
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New Insights on Biosynthesis of Nanoparticles Using Plants Emphasizing the Use of Alfalfa (Medicago sativa L.) by Inese Kokina, Ilona Plaksenkova, Lauris Jankovskis, Marija Jermaļonoka, Renata Galek

“…For discussion, results showed that biosynthesis of NPs allows obtaining NPs with reduced toxicity, and their size and shape depend on the type and number of biomolecules present in plants. …”
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Osthole regulates N6‐methyladenosine‐modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease by Xian Lin, Jian Chen, Cheng Tao, Lianxiang Luo, Juan He, Qingwen Wang

“…Furthermore, OS restrained the proliferation and polarization of M2 macrophages to inhibit the aggregation of lung interstitial CD11b+ macrophages, and the effectiveness and non‐toxicity of OS in suppressing RA and RA‐ILD progression were verified in vivo. …”
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Cellulose nanofiber reinforced curcumin-infused calcium phosphate silicate cement for various bone-tissue engineering application by Xiu Guo Lu, Xiu Guo Lu, Sha Li Meng, Sha Li Meng, Qiu Jing Zhou, Qiu Jing Zhou, Tao Wu, Tao Wu, Xing Tian Gong, Qiong Wu

“…Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity toward pre-osteoblasts, highlighting CPSC-Cur’s potential as a promising material for repairing bone defects following cancer removal.ConclusionThis study lays the groundwork for future investigations into CPSC-Cur’s in vivo efficacy and its role in the clinical treatment of bone cancer.…”
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Geochemistry and human health risks of heavy metals in soils from gold mineralized Birimian rocks in Southwestern Burkina Faso by Kadidiatou Coulibaly, Aboubakar Sako

“…According to the median effect range mean quotient (MERMQ), 87.9% (MERMQ >0.11) of the samples had 29% probability of being toxic. In contrast, the contamination severity indices (CSI) ranged from 0.17 to 2.11, indicating a very low to moderate probability toxicity. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…The fish groups were subjected to three distinct temperatures (30, 32, and 34 °C) and subsequently separated into two groups: 0 and 10 mg/L of PVC-NPs, as it is expected that these temperatures may modify their chemical properties, which can influence their absorption and toxicity in fish. After 4 days, the biochemical response of fish exposed to PVC-NPs and elevated temperatures showed a significant increase in the levels of plasma total proteins, albumin, globulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, and uric acid. …”
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Enhancing food waste compost quality with nutrient amendments by John Nkansah, Samson Oduro-Kwarteng, Helen Essandoh, Richard Kuffuor

“…In all treatments, the C/N ratio reduced significantly, while concentrations of heavy metals (Pb and Zn) were within the acceptable international limits. Toxicity of composts to cucumber (Cucumis sativus) was ascertained. …”
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A Comparative In Vitro Study of the Effects of Separate and Combined Products of Citrus e fructibus and Cydonia e fructibus on Immunological Parameters of Seasonal Allergic Rhiniti... by E. W. Baars, M. C. Jong, I. Boers, A. F. M. Nierop, H. F. J. Savelkoul

“…The analyses demonstrated acceptable cell survival with no signs of toxicity. Citrus mainly had a selective effect on reducing allergen-specific chronic inflammatory (TNF-α; Citrus compared to Cydonia and Citrus/Cydonia: −87.4 (P<0.001) and −68.0 (P<0.05), resp.) and Th2 pathway activity (IL-5; Citrus compared to Cydonia: −217.8 (P<0.01); while, both Cydonia and Citrus/Cydonia mainly affected the induction of the allergen-specific Th1 pathway (IFN-γ; Cydonia and Citrus/Cydonia compared to Citrus: 3.8 (P<0.01) and 3.0 (P<0.01), resp.). …”
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Direct Hot Solid–Liquid Extraction (DH-SLE): A High-Yield Greener Technique for Lipid Recovery from Coffee Beans by Daliane Cláudia de Faria, Maria Eliana Lopes Ribeiro de Queiroz, Fábio Junior Moreira Novaes

“…Generally, n-hexane (toxicity grade 5) is used as the solvent (≈300 mL; ≈30 g sample) at boiling temperatures (69 °C) for long times (≤16 h) under a chilled water reflux (≈90 L/h), proportionally aggravated by the number of repetitions and samples determined. …”
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Influence of Cooking by Boiling on Lead and Cadmium in Meat and Liver of Chickens by Wasan E Hashem, Raghad A Abdaljaleel

“… Heavy meals are widely known as environmental pollutants due to their toxicity, heat stability, long staying in the atmosphere, and their capability to accumulate in the body. …”
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Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer by Melike OZKAN, Irfan KARAHAN, Selim YALCIN, Gozde SENGUL AYCICEK

“…Conclusion: Chemotherapy toxicity may increase with PIM detected on diagnosis. …”
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Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of Scorpion <i>Liocheles australasiae</i> by Masahiro Miyashita, Naoya Mitani, Fuki Iwamoto, Mitsuki Hirota, Yoshiaki Nakagawa

“…Since LaIT5 did not show any toxicity against mice, it was concluded that its action is selective for insects.…”
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Biodegradation of Congo Red Azo Dye Using Lysinibacillus Capsici Immobilized on Polyurethane foam Biocarrier in Moving Bed Bioreactor by Soroush Dayani Najafabadi, Maryam Hasani Zonoozi, Roya Aliaskarian

“…Biosustainability, toxicity, and the potential for disruption of aquatic ecosystems and human health have made azo dyes into a serious environmental issue in industrial wastewater. …”
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Alkaline Activation of Basic Oxygen Furnace Slag Modified Gold Mine Tailings for Building Material by Tebogo Mashifana, Jessica Sebothoma, Thandiwe Sithole

“…The geopolymers passed the toxicity characteristic leaching procedure (TCLP), and the results yielded low heavy metals concentration, indicating that the geopolymers will not leach to the environment.…”
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