Triple-drug antibiotic therapy for disseminated nocardial abscess in the mediastinum and brain of an immunocompetent patient: a case report by Yue Zhang, Zhongchun Qi, Hua Li, Hui Gao

“…A triple-drug antibiotic regimen has been found to be effective in treatment with acceptable levels of toxicity.…”
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Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Results showed that increased expression of miRNA-375 interfered with the expression levels of both its target genes and ammonia toxicity-related genes, which would probably lead to oxidative stress, migration of damaged cells, apoptosis resistance, and increased possibility of tumor formation. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The progression of NAFLD is associated with the powerful toxicity of lipids released in the liver parenchyma upon the loss of the cell biomembrane integrity.Conclusions. …”
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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…This work focuses on salmeterol/fluticasone propionate combination and aspects which has to do with administration, monitoring, metabolism, toxicity, and adverse effects.…”
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Speciation of heavy metals in coastal water of Qeshm Island in the Persian Gulf by A.R. Karbassi, S. Tajziehchi, H. Khoshgalb

“…Since all the studied elements were within the water stability range, they were stable, and there were no environmental risks of contamination and toxicity. The results of cluster analysis did not show any relation between Eh and pH. …”
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Chitosan and its derivatives as promising plant protection tools by A. B. Shcherban

“…However, traditional, chemical PPPs, despite their effectiveness, have significant drawbacks, namely, pollution of environment, ecological damage, toxicity to humans. Recently, biological PPPs based on natural compounds have attracted more attention, since they do not have these disadvantages, but at the same time they can be no less effective. …”
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A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules by Tejaswini Masne, Dileep Kumar, Deepali Bansode

“…Furthermore, it discusses ongoing research efforts aimed at developing novel drug formulations, such as liposomal and nano-carrier-based delivery systems, to enhance drug efficacy and reduce toxicity. This article crucially focuses on future perspectives in heterocyclic drug therapies for leishmanial diseases. …”
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Photodegradation kinetics of Bilastine in tablets by Ariele Nunes Machado, Jéssica Resch Erd, Andressa Tassinari da Silva, Gabriela Rossi Brabo, José Luiz Ribeiro Portela, Lisiane Bajerski, Clésio soldateli Paim

“…This process is significant in environmental chemistry, where sunlight can degrade pollutants and materials, influencing their persistence and toxicity. Bilastine is a novel non-sedating histamine H1-receptor antagonist developed for the treatment of allergic rhino conjunctivitis and urticaria. …”
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Vaccines for cancer interception in familial adenomatous polyposis by David E. Johnson, Mary L. Disis

“…Immunologic memory will allow the immune response to persist and the specificity of the immune response will limit toxicity to the targeted polyp. This review will examine the current state of vaccines directed against FAP lesions and highlight the challenges and opportunities of translating vaccines for cancer interception in FAP to the clinic.…”
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The Multiple Effects of Precursors on the Properties of Polymeric Carbon Nitride by Wendong Zhang, Qin Zhang, Fan Dong, Zaiwang Zhao

“…Considering the cost, toxicity, and yield of the precursors and the properties of g-C3N4, the best precursor for preparation of g-C3N4 was melamine. …”
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Procyanidin A1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through regulating Keap1/Nrf2 pathway by Fangfang Yan, Qun Lu, Chengming Wang, Rui Liu

“…Importantly, there was no difference between A1 and D-A1 treated groups, indicating that A1 can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR.…”
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Mycotoxic effects of entomopathogenic fungi of fall armyworm (Spodoptera frugiperda J.E. Smith) on poultry feed safety by Sharai Silipiwe, Alice Nakhumicha Muriithi, Christopher Ochieng Ojiewo

“…About 3.98 μg /kg of aflatoxin was observed using the ELISA total assay which is within the threshold toxicity levels set in Kenya for feed of about 20 μg /kg. …”
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Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model by Zhiliang Chen, Tony C. H. Chow, Shicong Wang, Gigi C. T. Leung, Sharon L. Y. Wu, David T. Yew

“…Alcoholism is known to cause liver toxicity and is extensively researched. On the other hand, stress, depression, and obesity are interrelated conditions with alcoholism, and their medications would affect the liver itself. …”
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Metal Complexes and Their Role in Treatment of the Arthritis by Ejaz Ali, Kanwal Ashiq, Manhaz Ghulam Nabi, Maria Gul, Mubashra Gul

“…To find new treatments for diseases, it is suggested that the mechanism of action and potential toxicity of metal complexes must be assessed.…”
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Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines by Musthahimah Muhamad, Nurhidayah Ab.Rahim, Wan Adnan Wan Omar, Nik Nur Syazni Nik Mohamed Kamal

“…In this study, AgNPs-GA were endocytosed within lysosomes, which may direct to secondary toxicity effects including oxidative stress, impairment of the cell membrane, DNA fragmentation, and cell death. …”
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Nanoparticles in Hormonal Regulation of the Female Reproductive System by Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Sakthi Sanjana Deenadhayalan, Elizabeth Rani Edwin, Preethi Harikrishnan, Prathiba Balaji

“…However, the accumulation of NPs in reproductive organs raises concerns about their potential toxicity, particularly in terms of oxidative stress, inflammation, and DNA damage. …”
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Assessment of Heavy Metal Contamination in Paddy Field Soils: A Case Study in Ranau Valley, Sabah, Malaysia by Ahmad Damanhuri Nadrah, Harun Siti Norliyana, Abd Rahim Sahibin

“…Several metals, including Mn, Ni, and Cr, exceeded established soil toxicity thresholds, particularly in areas influenced by ultrabasic rocks and agricultural practices. …”
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Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro by Divya S. Varghese, Shama Parween, Mustafa T. Ardah, Bright Starling Emerald, Suraiya A. Ansari

“…Human embryonic stem cells (hESCs) are being used extensively in array of studies to understand different mechanisms such as early human embryogenesis, drug toxicity testing, disease modeling, and cell replacement therapy. …”
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Phytotoxicity of methylene blue to rice seedlings by X.Z. Yu, Y.X. Feng, D.M. Yue

“…Results showed that acute toxicity of methylene blue to rice seedlings was evident. …”
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Ciprofloxacin and Clozapine: A Potentially Fatal but Underappreciated Interaction by Jonathan M. Meyer, George Proctor, Michael A. Cummings, Laura J. Dardashti, Stephen M. Stahl

“…The postmortem femoral clozapine plasma level was dramatically elevated at 2900 ng/mL, and the cause of death was listed as acute clozapine toxicity. Conclusion. Given the potentially fatal pharmacokinetic interaction between clozapine and ciprofloxacin, clinicians are advised to monitor baseline clozapine levels prior to adding strong CYP450 1A2 inhibitors, reduce the clozapine dose by at least two-thirds if adding a 1A2 inhibitor such as ciprofloxacin, check subsequent steady state clozapine levels, and adjust the clozapine dose to maintain levels close to those obtained at baseline.…”
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