Enhanced electrochemical performance of activated carbon derived from Acacia catechu bark by KOH activation for supercapacitor application by Mishra Pawan Kumar, Aryal Sabin, Bhakta Oli Hari, Shrestha Timila, Sapkota Thakur, Shrestha Ram Lal Swagat, Prasad Bhattarai Deval

“…Conversely, activated carbon sourced from biomass has emerged as a promising substitute due to its abundant presence in nature, high carbon content, and ease of processing with minimal toxicity. This study outlines the production of activated carbon from the matured bark of Acacia catechu through a sequence of processes, including pre-carbonization, carbonization, and activation at varying temperatures utilizing potassium hydroxide (KOH) as an activating agent. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…The chemotactic activity, toxicity, and phagocytosis of RAW 264.7 cocultured with different concentrations of MOMP were determined by Transwell, CCK-8, and neutral red uptake assays, respectively. …”
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Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications by Igor P. Oscorbin, Maria S. Kunova, Maxim L. Filipenko

“…However, <i>E. coli</i> PAP 1’s toxicity and instability in low-salt buffers complicate its expression and purification. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Later, computational tools were utilised for evaluating pharmacological attributes such as bioavailability score, Lipinski rule, absorption, distribution, metabolism, excretion and toxicity. Also, density functional theory (DFT) was used to compute quantum computations such as HOMO, LUMO, and chemical descriptors. …”
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Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…CsA treatment increased profibrotic TGF-β1 secretion in human mesangial cells whereas SRL did not, indicating a role for TGF-β in CsA toxicity. However we observed a synergistic nephrotoxic effect when CsA and SRL were co-administered. …”
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Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches by Weijia Zhi, Ying Li, Lifeng Wang, Xiangjun Hu

“…The transformative potential of these neuromodulation techniques in neuroscience research and clinical practice is underscored, emphasizing the need for integration and innovation in technologies, the optimization of delivery methods, the improvement of mediums, and the evaluation of toxicity to fully harness their therapeutic potential.…”
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Giant triple negative pregnancy-associated breast cancer (PABC) in a young woman: From diagnosis to therapy step by step: A case report by Micol Bottalico, Cristiana Boldrini

“…Imaging techniques such as ultrasonography (and mammography as an adjunct) and nonenhanced MRI (due to potential toxicity of gadolinium to the fetus) can be used for staging maternal breast disease during pregnancy. …”
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Removal of microplastics by algal biomass from aqueous solutions: performance, optimization, and modeling by Fatemeh Lotfigolsefidi, Mojtaba Davoudi, Maryam Sarkhosh, Ziaeddin Bonyadi

“…Abstract Microplastics (MPs) are emerging pollutants that pose significant risks to ecosystems due to their inherent toxicity, capacity to accumulate various pollutants, and potential for synergistic impacts. …”
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Evaluation of aluminum tolerance diversity in <i>Avena sativa</i> L. from the VIR collection by I. G. Loskutov, E. V. Blinova, L. Yu. Novikova

“…Despite the crop’s high environmental plasticity, an important condition for obtaining sustainable oat yields is the development of new cultivars with resistance to adverse environmental factors, including metal toxicity and high soil acidity.The objective of this work was to search for oat cultivars resistant to soil stressors (excess of Н+ and Al3+) for use in breeding for edaphic resistance.Materials and methods. …”
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Prevalence and Risk Factors of Medication Errors in Enteral Tube Feeding Among ICU Patients: A Comprehensive Cross-Sectional Analysis by Mansooreh Asghari-Varzaneh, Shirinsadat Badri, Shadi Farsaei

“…Some errors during drug gavage can lead to feeding tube blockage, reduced drug effectiveness, or drug toxicity. This study aimed to assess medication errors (MEs) in ICU patients using enteral feeding tubes and identify factors that affect ME incidents. …”
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Targeting BCMA in multiple myeloma: designs, challenges, and future directions by Yi Hu, Yuetao Xie, Xiaodong Wang, Lufeng Yang, He Geng, Zugang Yi, Yao Zhang, Lin Ma, Fang Chen

“…It critically addresses emerging challenges such as antigen escape and toxicity profiles, which have surfaced alongside therapeutic advances. …”
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Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential by Madhan Krishnan, Shyamaladevi Babu

“…Clinically, the application of these biomarkers has the potential to transform NPC management, enabling more precise interventions and improving survival rates while minimizing treatment-related toxicity. The integration of these biomarkers into routine clinical practice could facilitate early diagnosis, predict therapeutic responses, and identify patients at higher risk of recurrence. …”
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Safety of oil from Schizochytrium limacinum (strain ATCC‐20889) for use in infant and follow‐on formula as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Helle Katrine Knutsen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Irene Nuin Garciarena, Emanuela Turla, Harry J. McArdle

“…., the QPS status of the source of the NF, the production process, the composition of the NF, the absence of marine biotoxins and viable cells in the NF, the Panel considers that there are no concerns with regard to the toxicity of the NF. The Panel concludes that the NF is safe under the proposed conditions of use.…”
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Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin by Naveed Muhammad, Mohammad Saeed, Haroon Khan, Achyut Adhikari, Khalid Mohammed Khan

“…The whole plant of V. betonicifolia led to the isolation of 4-hydroxyl coumarin (4HC) which showed substantial safety profile in acute toxicity test. When challenged in Traction and Chimney tests, it showed significant (P<0.05) muscle relaxant effect in both muscle relaxant paradigms at 20 and 30 mg/kg during various assessment times. …”
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Genome-wide identification of the ATP-dependent zinc metalloprotease (FtsH) in Triticeae species reveals that TaFtsH-1 regulates cadmium tolerance in Triticum aestivum. by Yuxi Huang, Lifan Cao, Tanxing Chen, Xiaoqiang Chang, Yumei Fang, Liuliu Wu

“…Barley stripe mosaic virus-induced gene silencing (BSMV-VIGS) technology confirmed the function of TaFtsH-1, indicating that silencing TaFtsH-1 enhances common wheat's resistance to cadmium (Cd) toxicity. In summary, this study offers an in-depth understanding of the FtsH gene family in wheat, establishing a solid basis for comprehending its functions, genetic mechanisms, and improving wheat's tolerance to heavy metal contamination.…”
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Oxidative Thermolysis of Sulfobutyl-Ether-Beta-Cyclodextrin Sodium Salt: A Kinetic Study by Ionuț Ledeți, Claudia Temereancă, Amalia Ridichie, Adriana Ledeți, Denisa Laura Ivan, Gabriela Vlase, Titus Vlase, Carmen Tomoroga, Laura Sbârcea, Oana Suciu

“…As a derivative of beta-cyclodextrin, it is produced by introducing sulfobutyl ether groups into the beta-cyclodextrin molecule, which significantly increases its water solubility and decreases its toxicity compared to unmodified cyclodextrins. This study investigates the spectral and PXR diffraction characterization of SBECD, its thermal stability profile, and decomposition mechanism using isoconversional methods. …”
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Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion by Nadine Monteiro, Joana Silvestre, João Gonçalves-Pereira, Camila Tapadinhas, Vitor Mendes, Pedro Póvoa

“…CCB poisoning is associated with significant cardiovascular toxicity and is potentially fatal. Currently, there is no specific antidote and the treatment of CCB poisoning is supportive; however, this supportive therapy is often insufficient. …”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Binding of SSL5 was rapid and without observed toxicity. Competition of SSL5 with the binding of three anti-PSGL-1 antibodies and P-selectin to HL-60 cells identified PSGL-1 as the ligand on HL-60 cells. …”
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A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. These effects might be elucidated by the upregulated inflammation-associated proteins in ΔarrS. …”
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Nanoliposomal Coencapsulation of Dorema aucheri Extract and Curcumin; Enhanced Cytotoxicity, Apoptosis Induction, and Inhibition of EGFR Gene Expression in Oral Cancer Cells OCC-02 by Mahshid Azizi, Ghasem Ghalamfarsa, Fatemeh Khosravani, Hassan Bardania, Shahriar Azizi

“…Free curcumin, the extract, and the curcumin-extract combination showed dose-dependent toxicity against cancer cells; yet, the extract (IC50: 86 µg/ml) and curcumin-extract (IC50: 65 µg/ml) activities were much more than curcumin (IC50: 121 µg/ml). …”
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