Theranostic Contact Lens for Ocular Cystinosis Utilizing Gold Nanoparticles by Eunbe Ha, Hwajeong Kang, Hyeran Noh

“…The current treatment involves frequent administration of cysteamine eye drops, which suffer from low bioavailability and can lead to drug toxicity, making it essential to prescribe an appropriate dosage based on the patient’s condition. …”
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Evaluation of antibiofilm activity of Thymus syriacus essential oil against clinically isolated MDR bacteria by Basem Battah, Anas Rajab, Lama Shbibe, Jagjit Singh Dhaliwal, Khang Wen Goh, Long Chiau Ming, Yaman Kassab, Abdelhakim Bouyahya, Mahibub Mahahamadsa Kanakal, Chadi Soukkarieh

“…More studies are needed in order to continue studying this oil and evaluate its other medicinal properties and toxicity.  …”
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A Facile Synthesis of Montmorillonite Supported CdAl2O4 Nanocomposites with Photocatalytic and Hydrophobic Properties by Kumar Rajathi, Kalpana

“… The hydrothermal co-precipitation method was successfully employed to synthesize CdAl2O4 supported by natural clay, montmorillonite to reduce the toxicity of solid and liquid wastes that cause serious harm to livestock and humans due to the discharge of dye wastes into water bodies. …”
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Quantum dot nanomaterials: Empowering advances in optoelectronic devices by Mariam Akter Mimona, Md Israfil Hossain Rimon, Fatema Tuz Zohura, Jannatul Mawya Sony, Samira Islam Rim, Md Mostafizur Rahman Arup, Md Hosne Mobarak

“…Nevertheless, the broad implementation of these technologies is impeded by problems such as exorbitant production costs, probable toxicity, and environmental instability. Novel synthesis strategies, such as nonorganometallic approaches and microwave-based procedures, are addressing these problems by strengthening safety, reducing expenses, and improving the photostability of quantum dots. …”
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How endocrine disruptors affect fish reproduction on multiple levels: A review by Socha Magdalena, Chyb Jarosław, Suder Aleksandra, Bojarski Bartosz

“…Even at low concentrations, EDCs can exhibit reproductive toxicity in fishes. They can affect the functioning of certain systems within the hypothalamus (Kiss/GPR54, GnRH) and can also impact luteinizing hormone (LH) secretion in the pituitary. …”
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Treatment-related mortality in head and neck cancer patients receiving chemotherapy and radiation: results of a meta-analysis of published trials by Cristina Gurizzan, Michela Cinquini, Lorenzo Legramandi, Carlo Resteghini, Marco Siano, Cristiana Bergamini, Luigi Lorini, Davide Smussi, Alberto Paderno, Lisa Licitra, Paolo Bossi

“…Integrated chemoradiation (CRT) treatments result in a non-negligible rate of severe toxic effects. Treatment-related death (TRD) is a crucial topic for physicians involved in the curative treatment of HNC. …”
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Exploring the therapeutic potential of Asparagus africanus in polycystic ovarian syndrome: a computational analysis by Riaz Sania, Haider Fatima, ur-Rehman Rizwan-, Zafar Aqsa

“…The results underscored the lead compound’s superiority, demonstrating favorable pharmacokinetics, ADME characteristics, and strong molecular binding without any observed toxicity in comparison to standard drug. This study, by leveraging natural compounds sourced from A. africanus, provides valuable insights and advances towards developing more effective and safer treatments for PCOS. …”
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The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics by Arwa M. Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali SK Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim

“…Pharmacometabolomics which is an approach to identify novel biomarkers of drug response or toxicity in biofluids has been investigated to predict drug response. …”
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Busting the Resistance: Antimicrobial Activity of Plant-Infused Nanoemulsions against Neisseria gonorrhoeae by Deshanta Naicker, Rowen Govender, Nathlee S. Abbai

“…The study also assessed the toxicity of these plant nanoemulsions using human erythrocytes. …”
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Long-term outcomes of LDR-brachytherapy for localized prostate cancer by Lauri Mäkelä, Anssi Pétas, Arto Mikkola, Harri Visapää

“…IntroductionThis retrospective study aims to evaluate the long-term efficacy and urinary toxicity of LDR-brachytherapy for localized prostate cancer.Materials and methods235 primary prostate cancer patients treated with LDR-brachytherapy and subsequently followed up in our center were included in this study. …”
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Fetal Safety in MRI During Pregnancy: A Comprehensive Review by Gal Puris, Angela Chetrit, Eldad Katorza

“…Regarding gadolinium-based contrast agents, the evidence is conflicting: while some studies suggest risks such as stillbirth and rheumatological conditions, animal studies show minimal fetal retention and no significant toxicity, and later clinical research has not substantiated these risks. …”
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Histological Characterization of the Dicer1 Mutant Zebrafish Retina by Saeed Akhtar, Sarita Rani Patnaik, Rakesh Kotapati Raghupathy, Turki M. Al-Mubrad, John A. Craft, Xinhua Shu

“…DICER1 was recently shown to have another function of silencing the toxicity of Alu RNAs in retinal pigment epithelium (RPE) cells, which are involved in the pathogenesis of age related macular degeneration. …”
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Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva by Raphael Hösli, Stefan König, Stefan F. Mühlebach

“…Phenytoin (PHT) is one of the most often used critical dose drugs, where insufficient or excessive dosing can have severe consequences such as seizures or toxicity. Thus, the monitoring and precise measuring of PHT concentrations in patients is crucial. …”
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Green Synthesis of Copper Nanoparticles from the Aqueous Extract of <i>Lonicera japonica</i> Thunb and Evaluation of Its Catalytic Property and Cytotoxicity and Antimicrobial Activ... by Weijie Yu, Jingyi Tang, Chunxia Gao, Xuesong Zheng, Peizhi Zhu

“…The experiment showed that after multiple cycles, it can also quickly and effectively reduce methylene blue. To evaluate the toxicity of Cu NPs, experiments were conducted using HUVEC and MC3T3-E1 cells. …”
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In Silico Screening, Synthesis and In Vitro Evaluation of Some Quinazolinone and Pyridine Derivatives as Dihydrofolate Reductase Inhibitors for Anticancer Activity by A. G. Nerkar, A. K. Saxena, S. A. Ghone, A. K. Thaker

“…These compounds were then subjected for in vitro anticancer evaluation against five human cancer cell-lines for anticancer cyto-toxicity assay. Methotrexate (MTX) was used as standard for this evaluation to give a comparable inhibition of the cell proliferation by DHFR inhibition. …”
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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach by Yedi Herdiana, Yoga Windhu Wardhana, Insan Sunan Kurniawansyah, Dolih Gozali, Nasrul Wathoni, Ferry Ferdiansyah Sofian

“…Nanoparticle drug delivery enhances biological availability and delivery to targets, which may increase therapeutic efficacy and decrease general toxicity. The preventive approach again cannot be ignored, mainly keeping up certain modifications in diet and weight, along with pharmacological therapies to reduce uric acid (UA) levels and to decrease the frequency of acute attacks. …”
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Addressing the Scientific Gaps Between Life Cycle Thinking and Multi-Criteria Decision Analysis for the Sustainability Assessment of Electric Vehicles’ Lithium-Ion Batteries by Maria Tournaviti, Christos Vlachokostas, Alexandra V. Michailidou, Christodoulos Savva, Charisios Achillas

“…Life cycle carbon emissions and toxicity, material criticality, life cycle costs, specific energy, safety, and durability were considered in the analysis as key parameters of the transition to electric mobility. …”
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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers. by George F Wohlford, Leo F Buckley, Dinesh Kadariya, Taeshik Park, Juan Guido Chiabrando, Salvatore Carbone, Virginia Mihalick, Matthew S Halquist, Adam Pearcy, Dana Austin, Cohava Gelber, Antonio Abbate, Benjamin Van Tassell

“…Safety monitoring included vital signs, laboratory examinations (including hematology, coagulation, platelet function, chemistry, myocardial toxicity) and electrocardiography (to measure effect on PR, QRS, and QTc).…”
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Cardiogenic Shock in a Hemodialyzed Patient on Flecainide: Treatment with Intravenous Fat Emulsion, Extracorporeal Cardiac Life Support, and CytoSorb® Hemoadsorption by Nicolas De Schryver, Philippe Hantson, Vincent Haufroid, Mélanie Dechamps

“…Hemodynamic condition remained stable, and the toxicity of flecainide was initially not suspected until she developed within 8 hours a cardiogenic shock requiring vasopressors. …”
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Sub-lethal effects of acetamiprid on the gills of the bleak Alburnus alburnus: histopathological and molecular alterations by R. Agaguena, N. Zaidi, E. Brunelli, A. Hamdani, R. Macirella

“…Our results highlight the importance of expanding the panel of ecotoxicological tests required to approve agrochemical compounds and using different diagnostic tools for an in-depth examination of xenobiotic toxicity.…”
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