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    Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population by Marie-Ming Aynaud, Lauren Caldwell, Khalid N. Al-Zahrani, Seda Barutcu, Kin Chan, Andreea Obersterescu, Abiodun A. Ogunjimi, Min Jin, Kathleen-Rose Zakoor, Shyam Patel, Ron Padilla, Mark C. C. Jen, Princess Mae Veniegas, Nursrin Dewsi, Filiam Yonathan, Lucy Zhang, Amelia Ayson-Fortunato, Analiza Aquino, Paul Krzyzanowski, Jared Simpson, John Bartlett, Ilinca Lungu, Bradly G. Wouters, James M. Rini, Michael Gekas, Susan Poutanen, Laurence Pelletier, Tony Mazzulli, Jeffrey L. Wrana

    Published 2024-12-01
    “…We previously described C19-SPAR-Seq, a high-throughput, next-generation sequencing platform to detect SARS-CoV-2 that we here deployed to systematically profile variant dynamics of SARS-CoV-2 for over 3 years in a large, North American urban environment (Toronto, Canada). Sequencing of the ACE2 receptor binding motif and polybasic furin cleavage site of the Spike gene in over 70,000 patients revealed that population sweeps of canonical variants of concern (VOCs) occurred in repeating wavelets. …”
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  3. 43

    Impact of interventions on mpox transmission during the 2022 outbreak in Canada: a mathematical modeling study of three different cities by Fanyu Xiu, Carla M. Doyle, Jorge Luis Flores Anato, Jesse Knight, Linwei Wang, Joseph Cox, Daniel Grace, Trevor A. Hart, Terri Zhang, Shayna Skakoon-Sparling, Milada Dvorakova, Rita Shahin, Herveen Sachdeva, Nathan Lachowsky, Hind Sbihi, Darrell H.S. Tan, Michael A. Irvine, Sharmistha Mishra, Mathieu Maheu-Giroux

    Published 2025-04-01
    “…Methods: We estimated changes in sexual behaviors during the outbreak using 2022 data from the Engage Cohort Study, which recruited self-identified GBM in Montréal, Toronto, and Vancouver (n = 1,445). We developed a transmission dynamic model to estimate the fraction of new infections averted due to the three interventions in each city. …”
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