Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer:... by Joachim G J V Aerts, Sjoerd H van der Burg, Martijn P Lolkema, Sai Ping Lau, Freek R van ’t Land, Marjolein Y V Homs, Casper H J van Eijck

“…The primary endpoint is safety and tolerability of the combination immunotherapy. To determine the maximum tolerated dose, DCs will be given at a fixed dosage and anti-CD40 agonist in a traditional 3+3 dose-escalation design. …”
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Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia by Samuel Dagogo-Jack, Jim Wan, Chimaroke Edeoga, Peace Asuzu

“…Assessments included anthropometry, oral glucose tolerance test, insulin sensitivity (hyperinsulinemic euglycemic clamp, HEC), insulin secretion (intravenous glucose tolerance test, IVGT), and disposition index (DI). …”
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Uncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park by Sukanya Acharyya, Soumya Majumder, Sudeshna Nandi, Arindam Ghosh, Sumedha Saha, Malay Bhattacharya

“…Four high tolerance bacterial strains, MTS2C, MTS3A, MTS4B and MTS6A, were further characterized for potential use in bioremediation strategies. …”
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Impact of introducing transnasal endoscopy on expanding diagnostic endoscopy services by Nigel Trudgill, Hasan Haboubi, Jeff Turner, Laura Munglani, Tom Crosby, Ben Thomas Crosby, Karen Wright, Kay Charles, Wendy Evans, Megan Mathias, Stevie Davies, Badr Abdalla

“…In a modern healthcare service, TNE is cheaper, better tolerated and outperforms TOE in multiple domains.…”
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Muslim Turcophobia: A Study of Two Missionary Authors by Murat Köylü

“…The seven stories of the sky, which their ancestors saw as Uçmak, the fact that hell is seven stories below the earth, free thought and tolerance in both religions and the fact that there is only one God religion. …”
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Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…Although liver enzymes were elevated at the highest doses, other biochemical and hematological parameters remained unchanged. CSE was well-tolerated, as no serious adverse effects were observed; however, a reduction in motor activity was noted in the highest dose group, highlighting the need for further investigation, which is proposed for future studies.…”
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Molecular and functional characterization of Accl(2)efl: A biomarker for heavy metal stress in Apis cerana cerana by Yu-Lin Xu, Ling Peng, Jun-Jie Li, Wen-Feng Chen

“…Our study encompassed assessing the role of Accl(2)efl in the response of bees to various stressful environments and its involvement in tolerance to heavy metals (Cd and Hg). Furthermore, we employed the RNAi technology to delve into the response mechanisms of Accl(2)efl under Cd and Hg stress. …”
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Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits by Jun Zhou, Christopher J. Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily Gomme, Rani S. Sellers, Cynthia M. Rohde

“…<b>Conclusions</b>: RSVpreF was well-tolerated both locally and systemically without any adverse effects on reproductive and developmental endpoints.…”
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Global demand for rice genetic resources by Nelissa Jamora, Venuprasad Ramaiah

“…The traits sought most often were tolerances to environmental stresses, followed by tolerance or resistance to biotic stresses. …”
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Development of a Quinoa-Based Fermentation Medium for Propagation of Lactobacillus Plantarum and Weissella Confusa in Opaque Beer Production by Shepherd Manhokwe, Tatenda Musarurwa, Talknice Z. Jombo, Desmond T. Mugadza, Amiel Mugari, Joseph Bare, Scelo Mguni, Fidelis Chigondo, Jane Tafadzwa Muchekeza

“…An evaluation of the stability and tolerance of the LAB under various stress conditions was also done. …”
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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…Conclusion: AUP1602-C was safe and well tolerated and demonstrated dose-dependent efficacy in patients with nhDFU. …”
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Safety during surgical resection of the sclera in patients with primary and secondary glaucoma by A.Yu. Kazantzeva, E.A. Korchuganova

“…All patients received topical maximally tolerated antihypertensive therapy before surgery (on average, 4 drugs individually and in the form of fixed combinations). …”
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Biodistribution of a Mitochondrial Metabolic Tracer, [18F]F-AraG, in Healthy Volunteers by Jelena Levi, Heying Duan, Shahriar Yaghoubi, Juliet Packiasamy, Lyna Huynh, Tina Lam, Faiq Shaikh, Deepak Behera, Hong Song, Joseph Blecha, Salma Jivan, Youngho Seo, Henry F. VanBrocklin

“…PET/MR examination was well tolerated, and no adverse effects to the administration of [18F]F-AraG were noted by the study participants. …”
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Gender Differences Are a Leading Factor in 5-Year Survival of Patients with Idiopathic Pulmonary Fibrosis over Antifibrotic Therapy Reduction by Pasquale Tondo, Giulia Scioscia, Cosimo C. De Pace, Fabiola Murgolo, Federica Maci, Giulia M. Stella, Dalila Pescatore, Maria Pia Foschino Barbaro, Donato Lacedonia

“…Women had better survival (51.2 vs. 40.8 ± 19.2 months; <i>p</i> = 0.005) despite more frequent biopsy use (36% vs. 17%; <i>p</i> = 0.013). Women tolerated longer therapy better (<i>p</i> = 0.001). …”
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Black Soldier Fly (<i>Hermetia illucens</i>) Larvae as a Protein Substitute in Adverse Food Reactions for Canine Dermatitis: Preliminary Results Among Patients by Nuttawan Srifawattana, Yuthana Phimolsiripol, Pinpanit Boonchuay, Kannika Na-Lampang, Promporn Piboon, Sonthaya Umsumarng, Korakot Nganvongpanit

“…We evaluated BSF larvae’s safety, tolerance, and effectiveness as a novel protein source in dogs with AFRs. …”
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Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa by Keneth Iceland, Kasozi, Zirintunda, Gerald, Ssempijja, Fred, Buyinza, Bridget, Alzahrani, Khalid J., Matama, Kevin, Nakimbugwe, Helen N., Alkazmi, Luay, Onanyang, David, Bogere, Paul, Ochieng, Juma John, Islam, Saher, Matovu, Wycliff, Nalumenya, David Paul, Batiha, Gaber El-Saber, Osuwat, Lawrence Obado, Abdelhamid, Mahmoud, Shen, Tianren, Omadang, Leonard, Welburn, Susan Christina

“…Tolerance is influenced by age, sex, species, and physiological condition and parasite challenge. …”
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Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial by Chaoying Hu, Yibo Zhou, Xing Meng, Jianhua Li, Jinxia Chen, Zhifang Ying, Xiaoliang Sunney Xie, Yaling Hu, Yunlong Cao, Ronghua Jin

“…This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, and immunogenicity of the SA55 nasal spray in healthy individuals. …”
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Repetition of Prediabetes Enhances the Risk of Developing Diabetes by Yoshihiro Numata, Toshihide Ohya, Yasuhiko Nitta, Yumiko Yoshinaka, Azusa Shogakiuchi, Akihiro Toyota

“…They were classified as normal glucose tolerance or prediabetes as their yearly status of glucose tolerance for three years; furthermore, the individuals classified as prediabetes were subclassified into 3 groups. …”
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Italian Expert Opinion on Chronic Hand Eczema: from Guidelines to Clinical Practice by Luca Stingeni, Maria Concetta Fargnoli, Fabrizio Guarneri, Anna Balato, Monica Corazza, Anna Belloni Fortina, Piergiacomo Calzavara Pinton, Antonio Costanzo, Silvia Mariel Ferrucci, Luigi Naldi, Giovanni Pellacani, Ketty Peris, Francesca Prignano, Giampiero Girolomoni

“…Experts emphasized the need for effective and well-tolerated long-term therapies, improved disease awareness, and communication among physicians and patients.…”
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“Earlyploid” - Tetraploid Annual Ryegrass by Ann R. Blount, Gordon M. Prine, Cheryl L. Mackowiak, Kevin E. Kenworthy, Jeffery C. Jones, Paul E. Reith

“…It offers excellent disease resistance and sufficient cold tolerance to be grown successfully in the southern annual ryegrass region of the U.S. …”
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