The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…Acute toxicity assays revealed reduced hepatotoxicity at doses of 75 and 150 mg/kg in mice, with improved tolerance. In repeated-dose toxicity studies, DX126-262 was well tolerated in rats at doses up to 200 mg/kg, with the highest non-severely toxic dose (HNSTD) established at 100 mg/kg. …”
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Different post-pancreatectomy glucagon responses to a meal test between surgical approaches by Tsuguka Matsuda, Natsumi Himeno, Akira Nakashima, Naoya Nakagawa, Toshihiko Kohashi, Dan Kawamori, Nozomu Kamei

“…Postoperative plasma glucose, serum insulin, and serum C-peptide levels during the liquid meal tolerance test were not significantly different between the two groups. …”
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Multi-environment field trials for wheat yield, stability and breeding progress in Germany by Tien-Cheng Wang, Till Rose, Holger Zetzsche, Agim Ballvora, Wolfgang Friedt, Henning Kage, Jens Léon, Carolin Lichthardt, Frank Ordon, Rod J Snowdon, Andreas Stahl, Hartmut Stützel, Benjamin Wittkop, Tsu-Wei Chen

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Long-Term Dietary Nitrate Supplementation Does Not Prevent Development of the Metabolic Syndrome in Mice Fed a High-Fat Diet by V. B. Matthews, R. Hollingshead, H. Koch, K. D. Croft, N. C. Ward

“…Mice on the high-fat diet also had impaired glucose tolerance that was not affected by dietary nitrate. …”
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Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma by Cheng Tan, Liang Liu, Xiaoyang Liu, Ling Qi, Weiyao Wang, Guifang Zhao, Libo Wang, Yimeng Dai

“…Lastly, PTGS2 was proved to facilitate tumor cell proliferation and improve the radio‐tolerance. Conclusion PTGS2/NF‐κB signaling pathway was involved in radio‐tolerance of glioma cells, which provided a new insight into glioma therapy.…”
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Exploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA by Panpan Shang, Lei Bi, Wenwen Li, Xiaoli Zhou, Yanlong Feng, Jiahai Wu, Bing Zeng

“…Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. …”
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Drought induced metabolic shifts and water loss mechanisms in canola: role of cysteine, phenylalanine and aspartic acid by Raed Elferjani, Shankar Pahari, Raju Soolanayakanahally, Krista Ballantyne, Eiji Nambara

“…However, the higher level of phenylalanine in the drought-tolerant canola cultivar is suggestive that this amino acid is important for adaptation to drier climates. …”
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Characterization of a Natural Accession of <i>Elymus sibiricus</i> with <i>In Situ</i> Hybridization and Agronomic Evaluation by Yizhuo Liu, Jiarui Ding, Chunfei Wu, Weiwei Song, Xinyu Zhao, Haibin Zhao, Yunfeng Qu, Hui Jin, Rui Zhang, Mingyao Li, Xinyu Yan, Liangyu Zhu, Yaqi Bao, Dianhao Liu, Xinling Li, Lei Cui, Hongjie Li, Yanming Zhang

“…<i>Elymus sibiricus</i>, valued for its perennial nature, broad adaptability, strong cold tolerance, and high economic value in forage production, plays a crucial role in combating grassland degradation, desertification, and salinization. …”
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Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage by Robert L. Eoff, Jeong-Yun Choi, F. Peter Guengerich

“…Part of this so-called DNA damage tolerance pathway involves the recruitment of specialized DNA polymerases to sites of stalled or collapsed replication forks. …”
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Bipolar Disorder and Multiple Sclerosis: A Case Series by Youssef Sidhom, Mouna Ben Djebara, Yosr Hizem, Istabrak Abdelkefi, Imen Kacem, Amina Gargouri, Riadh Gouider

“…We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.…”
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Technological Potential of Lactobacillus Strains Isolated from Fermented Green Olives: In Vitro Studies with Emphasis on Oleuropein-Degrading Capability by Massimo Iorizzo, Silvia Jane Lombardi, Vincenzo Macciola, Bruno Testa, Giuseppe Lustrato, Francesco Lopez, Antonella De Leonardis

“…Moreover, all strains showed very good tolerance to common olive phenol content (0.3% total phenol) and high oleuropein-degrading capability. …”
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The first experience with sodium‐glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure by Anastasia D. Egorova, Marieke Nederend, Laurens F. Tops, Hubert W. Vliegen, Monique R.M. Jongbloed, Philippine Kiès

“…Treatment with dapagliflozin was well tolerated and resulted in (small) subjective and objective functional and echocardiographic improvement and a reduction in heart‐failure‐related hospitalizations.…”
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Modern Approaches to <i>H. pylori</i> Eradication Therapy in Adults (Literature Review and Resolution of Experts Council) by V. Т. Ivashkin, A. I. Ulyanin, I. V. Mayev, R. S. Kozlov, M. A. Livzan, S. R. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, D. S. Bordin, N. N. Dekhnich, N. V. Korochyanskaya, T. L. Lapina, E. A. Poluektova, V. I. Simanenkov, A. S. Trukhmanov, I. B. Khlynov, V. V. Tsukanov, A. A. Sheptulin

“…The inclusion of certain probiotics in eradication regimens improves treatment tolerance, reduces the risk of adverse events, improves patient compliance and eradication rates.…”
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Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy by Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah

“…Treatment of CLL with ibrutinib therapy is generally well tolerated; however, serious opportunistic infections are being reported in patients treated with ibrutinib. …”
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Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation by Jie Wang, Peiling Luo, Jingjie Zhao, Junhua Tan, Feifan Huang, Ruiying Ma, Peng Huang, Meiying Huang, Yuming Huang, Qiuju Wei, Liuzhi Wei, Zechen Wang, Lingzhang Meng

“…Immune tolerance research is essential for kidney transplantation. …”
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Transcriptome Comparison Reveals Distinct Selection Patterns in Domesticated and Wild Agave Species, the Important CAM Plants by Xing Huang, Bo Wang, Jingen Xi, Yajie Zhang, Chunping He, Jinlong Zheng, Jianming Gao, Helong Chen, Shiqing Zhang, Weihuai Wu, Yanqiong Liang, Kexian Yi

“…Agave species are an important family of crassulacean acid metabolism (CAM) plants with remarkable tolerance to heat and drought stresses (Agave deserti) in arid regions and multiple agricultural applications, such as spirit (Agave tequilana) and fiber (Agave sisalana) production. …”
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Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots by Ting Wang, Fanhua Wang, Shuhan Deng, Kailai Wang, Dan Feng, Fan Xu, Weijun Guo, Jia Yu, Yue Wu, Hada Wuriyanghan, Shang-Tong Li, Xiaofeng Gu, Liang Le, Li Pu

“…We find that cortex size strongly correlated with heat tolerance that is experimentally validated by using inbred lines and genetic mutation analysis of one candidate gene in maize, providing potential HS tolerance indicator and targets for crop improvement. …”
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Response growth and yield of local black rice variety mutiara to drought stress by Purwanto Edi, Taqiy Apta Danendra Faiq, Cahyo Handoyo Gani, Rahayu Muji

“…The purpose of this study was to determine the level of tolerance of local black rice variety mutiara in response to growth and yield to drought stress. …”
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The gut microbiome and cross-reactivity of food allergens: current understanding, insights, and future directions by Carolina Taico Oliva, Ibrahim Musa, Daniel Kopulos, Fariba Ardalani, Anish Maskey, Aaron Wilson, Nan Yang, Xiu-Min Li, Xiu-Min Li, Xiu-Min Li

“…Additionally, we discuss microbial metabolites, particularly short-chain fatty acids (SCFAs), which enhance immune tolerance by promoting Treg differentiation and maintaining gut barrier integrity, thereby reducing allergen entry. …”
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Debate as an innovative technology of forming personal and meaningful positions of students by Song Lei

“…Debate is one of the most effective methods to promote the development of creative activity, oratorical skills and tolerance. Debate requires detailed investigation of controversial issues, and it is an excellent tool for developing critical thinking,logic skills, civilized discussion and democratic dialogue.…”
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