Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade by Yu Chen, Yu Guo, Wen Cheng, Jiahao Fan, Jiacheng Li, Jiajia Song, Xiaohai Yang, Kemin Wang, Jin Huang

“…Besides tumor killing and immune promotion, activated NS downregulate PD‐L1 expression, alleviating immune tolerance and evasion, thus enhancing the immune response. …”
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Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure by Karl Träger, Christian Schütz, Günther Fischer, Janpeter Schröder, Christian Skrabal, Andreas Liebold, Helmut Reinelt

“…CytoSorb treatment was safe and well tolerated, with no device-related adverse effects observed.…”
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Biological Characteristics and Whole Genome Analysis of vB_VpP_3, a Bacteriophage against Multi-drug Resistant Vibrio parahaemolyticus by LIU Qingqing, ZHANG Ming, YANG Wenjing, LIU Ke, LI Fan, LI Xuepeng, LI Jianrong, ZHANG Defu

“…The one-step growth curve showed that the latent period of the phage was 15 min, the average burst size was 110 PFU, and it was highly tolerant to the environment. Phage vB_VpP_3 belonged to the order Caudovirales of the family Podoviridae with a regular icosahedral head about 60 nm in diameter and a non-contractile tail about 20 nm in length. …”
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Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase by Gülşah P. Özgün, Emel B. Ordu, H. Esra Tütüncü, Emrah Yelboğa, Richard B. Sessions, Nevin Gül Karagüler

“…The thermodynamic and kinetic results suggest that 8 mutations on the first residue can be tolerated. Among all mutants, M1L has the best residual activity after incubation at 60°C with 17%. …”
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TDR-Model: Tomato Disease Recognition Based on Image Dehazing and Improved MobileNetV3 Model by Zhixiang Zhang, Tong Liu, Jinyu Gao, Meng Yang, Wenjun Luo, Fanqiang Lin

“…Employing the quad-tree spatial hierarchy search strategy, guided filtering, tolerance mechansim, and multi-scale color restoration (MSRCR) algorithm, an innovative improved version of DCP dehazing algorithm is realized. …”
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Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice by XuWen Mao, Guliruoyi Paerhati, Yuche Wu, Lu Feng Cheng

“…We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice.MethodsThe experimental analyses focused on the changes in lipid distribution, inflammatory cytokines, glucose tolerance, gut microbiota composition, and serum metabolomics of 60 C57BL/6N mice.ResultsThe experimental results demonstrated that I3C reduced body weight, hepatic steatosis, and systemic inflammation and improved insulin resistance in mice on a high-fat diet (HFD). …”
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Transcutaneous Vagus Nerve Stimulation Combined with Robotic Rehabilitation Improves Upper Limb Function after Stroke by Fioravante Capone, Sandra Miccinilli, Giovanni Pellegrino, Loredana Zollo, Davide Simonetti, Federica Bressi, Lucia Florio, Federico Ranieri, Emma Falato, Alessandro Di Santo, Alessio Pepe, Eugenio Guglielmelli, Silvia Sterzi, Vincenzo Di Lazzaro

“…Compared to traditional stimulation, noninvasive VNS seems to be safer and more tolerable. Further studies are needed to confirm the efficacy of this innovative approach.…”
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Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

“…In 2015, the release of well-tolerated, short course treatments (~12 weeks) able to cure the majority of treated HCV patients revolutionized HCV therapy. …”
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Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development by Montserrat Carrasco-Triguero, Helen Davis, Yuda Zhu, Daniel Coleman, Denise Nazzal, Paul Vu, Surinder Kaur

“…This assay showed good sensitivity, drug tolerance, and reproducibility across a variety of antibody-derived biotherapeutics without the need for optimization across molecules.…”
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Numerical and Experimental Investigations on Dynamic Response of Hydraulic Cylinder with 3D Spatial Joints considering Radial and Axial Clearances by Ke Chen, Guojun Zhang, Haishuo Wang, Rui Wu, Hongmei Zheng, Shunhua Chen

“…Radial clearance, particularly the axial clearance in the 3D joint of a mechanism owing to the assemblage, manufacturing tolerances, wear, and other conditions, has become a research focus in the field of multibody dynamics in recent years. …”
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Zinc Affects Differently Growth, Photosynthesis, Antioxidant Enzyme Activities and Phytochelatin Synthase Expression of Four Marine Diatoms by Thi Le Nhung Nguyen-Deroche, Aurore Caruso, Thi Trung Le, Trang Viet Bui, Benoît Schoefs, Gérard Tremblin, Annick Morant-Manceau

“…Among the four species, A. paludosa was the most sensitive and A. coffeaeformis, the most tolerant. A. acutiuscula seemed to be under metal starvation, whereas, to survive, only N. palea developed several stress responses.…”
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Double Barreled Wet Colostomy: Initial Experience and Literature Review by Luis Salgado-Cruz, Eloy Espin-Basany, Francesc Vallribera-Valls, Jose Sanchez-Garcia, Luis Miguel Jimenez-Gomez, Marc Marti-Gallostra, Ana Garza-Maldonado

“…In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment.…”
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Development and Validation of an Age-Specific Lower Extremity Finite Element Model for Simulating Pedestrian Accidents by Jing Huang, Yongcheng Long, Yu Yan, Lin Hu

“…However, current computational models only represent certain ages in the population, the age spectrum of the pedestrian victims is very large, and the geometry of anatomical structures and material property of the lower extremities changes with age for adults, which could affect the injury tolerance, especially in at-risk populations such as the elderly. …”
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Transcriptome Analysis of Interspecific Hybrid between Brassica napus and B. rapa Reveals Heterosis for Oil Rape Improvement by Jinfang Zhang, Guangrong Li, Haojie Li, Xiaobin Pu, Jun Jiang, Liang Chai, Benchuan Zheng, Cheng Cui, Zujun Yang, Yongqing Zhu, Liangcai Jiang

“…The hybrid between Brassica napus and B. rapa displays obvious heterosis in both growth performance and stress tolerances. A comparative transcriptome analysis for B. napus (AnAnCC genome), B. rapa (ArAr genome), and its hybrid F1 (AnArC genome) was carried out to reveal the possible molecular mechanisms of heterosis at the gene expression level. …”
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Setting of residue definitions and toxicological reference values for ethiprole by European Food Safety Authority (EFSA), Sofia Batista Leite, Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Mathilde Colas, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, Monica Fittipaldi Broussarad, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Jochem Louisse, Iris Mangas, Andrea Mioč, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Hermine Reich, Simone Rizzuto, Silvia Ruocco, Alessia Pia Scarlato, Andrea Simonati, Marta Szot, Andrea Terron, Anne Theobald, Manuela Tiramani, Alessia Verani, Elena Zioga

“…Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the original evaluating Member State (EMS), the United Kingdom, received an application from Bayer CropScience to set an import tolerance for the non‐approved active substance ethiprole in rice. …”
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Blockchain-Powered Secure and Scalable Threat Intelligence System With Graph Convolutional Autoencoder and Reinforcement Learning Feedback Loop by Mohamad Khayat, Ezedin Barka, Mohamed Adel Serhani, Farag Sallabi, Khaled Shuaib, Heba M. Khater

“…To secure the exchange of threat intelligence information, a safe blockchain network is used, which comprises Byzantine Fault Tolerance for high data integrity and Zero-Knowledge Proofs for access control. …”
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Multi-terminal flexible DC grid circuit breaker withstands multi-lightning strike analysis by Yutao Tang, Hongchun Shu, Kai He, Yue Dai, Yu Kuang, Yiming Han, Weijie Lou

“…The research results indicate that the energy-consuming branch has a certain tolerance to multi-lightning strikes. However, if the MOV collapses under multi-lightning strikes, it can lead to severe overvoltage issues. …”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…The identified QTLs, genes, and breeding lines from this study provide valuable resources for developing rice varieties with enhanced tolerance to deep soil emergence, making them well-suited for mechanized DSR systems.…”
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A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress by Nasrin Akbari, Reza Darvishzadeh

“…Undoubtedly, improving drought tolerance and developing high-yielding cultivars is one of the most important goals in breeding programs. …”
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Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…Conclusions IBI110 monotherapy and in combination with sintilimab were well-tolerated in Chinese patients with advanced solid tumors. …”
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