Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials by Abdallah R. Allam, Mohamed Salah Alhateem, Abdelrahman Mohamed Mahmoud

“…Conclusion Fezolinetant is efficient and well-tolerated in the treatment of postmenopausal women with VMS.…”
Get full text

Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study by Afnan AwadAllah Elgnainy, Mohammad Ismail Hamed, Wael Osman Mohamed, Nagwa Ali Sabri

“…We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. …”
Get full text

Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives by Ricardo P. Garay

“…The association of the senolytic drugs dasatinib and quercetin was well tolerated, with low brain penetration of dasatinib and undetectable levels of quercetin. …”
Get full text

Hypoglycemic Activity of Aqueous Root Bark Extract Zanthoxylum chalybeum in Alloxan-Induced Diabetic Rats by Moses Solomon Agwaya, Peter California Vuzi, Agnes Masawi Nandutu

“…The present study evaluated the effect of aqueous root bark extract of Zanthoxylum chalybeum on oral glucose tolerance and pancreas histopathology in alloxanized rats. …”
Get full text

A Cross-sectional Study on the Levels of Anxiety and Depression of People under Treatment for COVID-19 in Relation to Emotional Intelligence by Gopi Rajendhiran, V. Veera Balaji Kumar

“…Background: COVID-19 was one of the pandemics which had put human emotional tolerance into hazard and tested our endurance levels. …”
Get full text

Impact of salinity stress on the response of aloe vera from different breeders on coastal sand land by Aprilia Rennanti Lunnadiyah, Purwanto Edi, Suryanti Venty, Rahayu Muji

“….), a drought-resistant CAM (Crassulacean Acid Metabolism) plant with high economic potential, has the ability to tolerate dry environments but requires further study regarding its ability to withstand salinity stress, especially in coastal sandy soils impacted by climate change. …”
Get full text

Simulation and Analysis of Geomagnetically Induced Current Levels in Shandong Power Grid by Han Wang, Zan‐Yang Xing, Nanan Balan, Yan‐Ling Wang, Qing‐He Zhang, Li‐Kai Liang

“…Abstract Geomagnetically induced current (GIC) in utility systems such as electric power grids occurring during extreme geomagnetic storms can exceed the tolerance limit of the systems, which can cause serious system damages. …”
Get full text

Pain Experience and Behavior Management in Pediatric Dentistry: A Comparison between Traditional Local Anesthesia and the Wand Computerized Delivery System by Annelyse Garret-Bernardin, Tiziana Cantile, Vincenzo D’Antò, Alexandros Galanakis, Gabriel Fauxpoint, Gianmaria Fabrizio Ferrazzano, Sara De Rosa, Giulia Vallogini, Umberto Romeo, Angela Galeotti

“…The Wand system may provide a less painful injection when compared to the conventional local anesthesia and it seemed to be better tolerated with respect to a traditional syringe.…”
Get full text

Effect of Different Arbuscular Mycorrhizal Fungi on Growth and Physiology of Maize at Ambient and Low Temperature Regimes by Xiaoying Chen, Fengbin Song, Fulai Liu, Chunjie Tian, Shengqun Liu, Hongwen Xu, Xiancan Zhu

“…The results suggest that low temperature adversely affects maize physiology and AM symbiosis can improve maize seedlings tolerance to low temperature stress.…”
Get full text

Spaced Seed Data Structures for De Novo Assembly by Inanç Birol, Justin Chu, Hamid Mohamadi, Shaun D. Jackman, Karthika Raghavan, Benjamin P. Vandervalk, Anthony Raymond, René L. Warren

“…Further, we note that Bloom filters would be suitable to implicitly store spaced seeds and be tolerant to sequencing errors. Building on this concept, we describe a data structure for tracking the frequencies of observed spaced seeds. …”
Get full text

Successful Renal Transplantation after Presumed Cyanide Toxicity Treated with Hydroxocobalamin and Review of the Literature by Ryan J. Hendrix, Paulo N. Martins, Jeffrey S. Stoff, Aaron Ahearn, Adel Bozorgzadeh, Babak Movahedi

“…Hydroxocobalamin is the antidote for suspected acute cyanide toxicity. While largely tolerated by the recipient, there is concern over the potential functional implications of the associated side effects of dramatic tissue discoloration and development of oxalate crystals. …”
Get full text

Money plant disease atlas: A comprehensive dataset for disease classification in ornamental horticultureMendeley Data by Md. Seyam ali Biswas, MD Hasan Ahmad, Sajib Bormon, Rimon, Sohanur Rahman Sohag, Amatul Bushra Akhi

“…They say that these plants are attractive to many people owing to their tolerance to several conditions and easy care, therefore, it is no surprise that they are found in many households and workplaces. …”
Get full text

Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota by Ruting Zhong, Lanbin Chen, Yuanyuan Liu, Shouxia Xie, Sumei Li, Bin Liu, Chao Zhao

“…Additionally, it diminished the weight loss, reduced fasting blood glucose levels and hemoglobin A1c activity, and promoted glucose tolerance and fasting serum insulin activity in T2D mice. …”
Get full text

circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer by Taofang Hao, Yuanyuan Li, Qianyao Ren, Ying Zeng, Leyi Gao, Wenbo Zhu, Jiankai Liang, Yuan Lin, Jun Hu, Guangmei Yan, Shuxin Sun, Jing Cai

“…Pancreatic cancer is among the most challenging tumors to treat, and due to its immune tolerance characteristics, existing immunotherapy methods are not effective in alleviating the disease. …”
Get full text

<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant by Xing Wu, Meng-Fei Wanyan, Bao-Bao Shi, Rong Huang, Hui-Xiang Yang, Xian Wang, Ji-Kai Liu

“…Acute toxicity experiments showed that mice gavage orally with the fine active fraction had no significant animal toxicity at a dose of 2000 mg/kg, and the maximum tolerated dose (MTD) in mice was greater than 2000 mg/kg. …”
Get full text

Numerical Analyses of Earthquake Induced Liquefaction and Deformation Behaviour of an Upstream Tailings Dam by Muhammad Auchar Zardari, Hans Mattsson, Sven Knutsson, Muhammad Shehzad Khalid, Maria V. S. Ask, Björn Lund

“…Both types of earthquakes are predicted to induce tolerable magnitudes of displacements. The results of the postseismic slope stability analysis, performed for a state after a seismic event, suggest that the dam is stable during both the earthquakes.…”
Get full text

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes by Kira V. Derkach, Vera M. Bondareva, Oxana V. Chistyakova, Lev M. Berstein, Alexander O. Shpakov

“…The IS treatment of diabetic rats decreased the body weight, and improved glucose tolerance, insulin-induced glucose utilization, and lipid metabolism. …”
Get full text

Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet by Li Yuan, Ying Wang, Chunli Lu, Xiaoya Li

“…After 16 weeks of feeding, the islet function of the animals was evaluated by intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin releasing test (IPIRT). …”
Get full text

Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin sensitivity and lowered HOMA-IR. …”
Get full text

Early testing on S1 lines of black corn (Zea mays L.) from the Ecuadorian highlands by Jorge Merino, William Viera, Javier Garófalo, Paúl Mejía, Víctor Sánchez

“…germplasm from the Ecuadorian Higlands has low tolerance to inbreeding especially in starchy cultivars. …”
Get full text