Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…ObjectiveThis study aimed to evaluate the efficacy, tolerability, and safety of clozapine for treatment-resistant DB in youths with ASD. …”
Get full text

Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by Evgeny D. Fedorov, Viktor V. Veselov, Sergey V. Kashin, Ekaterina V. Tikhomirova, Alexey V. Veselov, Dmitry V. Zavyalov, Anne Kornowski, Tatyana Gorskaya, Magali Volteau, Thierry Ponchon

“…Both preparations were well tolerated. Despite the higher incidence of nausea in the OSS group, the patients showed significantly higher compliance with the OSS mode as compared to that of Macrogol.This study is registered with the ClinicalTrials.gov Registry of Clinical Trials, No. …”
Get full text

HbA1c Cutoff Point of 5.9% Better Identifies High Risk of Progression to Diabetes among Chinese Adults: Results from a Retrospective Cohort Study by Kai Liang, Chuan Wang, Fei Yan, Lingshu Wang, Tianyi He, Xiuping Zhang, Chengqiao Li, Weifang Yang, Zeqiang Ma, Aixia Ma, Xinguo Hou, Li Chen

“…In all, 2778 nondiabetic subjects (including 1901 women) underwent HbA1c testing and oral glucose tolerance test (OGTT) measurements at baseline and after 3 years. …”
Get full text

USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Animal experiments confirmed the effective role of the DGS and X-ray combined treatment in reducing tumor growth and irradiation tolerance of ESCA in vivo with undetectable toxicity. …”
Get full text

The Use of Cannabinoids to Treat Insomnia by V. Kutniauskaitė, G. Šegždaitė, G. Žilionytė, E. Pajėdienė

“…Additionally, there are safety concerns associated with cannabinoids, including potential negative impacts on the sleep quality, risk of abuse or dependence, and the development of tolerance with long-term use. This article provides a comprehensive review of literature concerning the effects and safety of cannabinoids on sleep and sleep-wake rhythms, as well as their potential benefits in treating insomnia and other sleep disorders. …”
Get full text

Green Biodiesel Synthesis Using Waste Shells as Sustainable Catalysts with Camelina sativa Oil by Yelda Hangun-Balkir

“…Camelina sativa oil is an appealing crop option as feedstock for biodiesel production because it has high tolerance of cold weather, drought, and low-quality soils and contains approximately 40% oil content. …”
Get full text

Microneedling with platelet-rich plasma versus microneedling with vitamin C in treatment of acne scars: comparative study by Khaled M. Tawfik, Mahmoud A.E. Makki, Fatma E.-Z.M. Mahmoud

“…Microneedling with PRP and vitamin C was well-tolerated with no major adverse events that were observed. …”
Get full text

Analysis of Model Fit and Test Information on Otis-Lennon School Ability Test Using Item Response Theory by Rey-Mark Basagre

“…Some items' p-values suggest local dependence, but it can be tolerated upon examination of some of the actual items. …”
Get full text

RESILIENCE AMONG DRUG ABUSER UNDER TREATMENT PROGRAM IN DRUG REHABILITATION CENTER IN SURABAYA by Fauziah Fitri Hernanto, Agung Putri Harsa, Roby Aji Permana

“…Drugs have three dangerous characteristics, namely, addiction, tolerance, and habituation that cause an addict to be compelled to continue using drugs or to try drugs again. …”
Get full text

Estimation of Copper and Cadmium Bioavailability in Contaminated Soil Remediated by Different Plants and Micron Hydroxyapatite by Lei Xu, Xiangyu Xing, Jianbiao Peng, Mingfei Ji

“….), cadmium (Cd)-hyperaccumulator (Sedum plumbizincicola), and copper (Cu)-tolerant plant (Elsholtzia splendens) were used as the phytoremediation plants aided by micron hydroxyapatite (1% wt). …”
Get full text

Efficacy of Adjunctive Treatments Added to Olanzapine or Clozapine for Weight Control in Patients with Schizophrenia: A Systematic Review and Meta-Analysis by Yun-Jung Choi

“…Adverse effects regarding adjunctive therapies were tolerable and showed statistically no significances compared to control groups. …”
Get full text

Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…These outcomes contrast starkly with popular teaching about chronic opioid therapy and affirm the potential for prolonged efficacy, tolerable side effects, enhanced function associated with improved comfort and minimal risk of aberrant drug-related behaviours consistent with addiction. …”
Get full text

Consumer Challenges of the Socio-Economically Disadvantaged in South Africa and the Role of Consumer Legislation by Lindeka Tentu, Karunanidhi Reddy

“…Due to their socio-economic challenges, these vulnerable consumers often tolerate unethical business practices and find it challenging to access legal support. …”
Get full text

An Area-Efficient Integrate-and-Fire Neuron Circuit with Enhanced Robustness against Synapse Variability in Hardware Neural Network by Arati Kumari Shah, Kannan Udaya Mohanan, Jisun Park, Hyungsoon Shin, Eou-Sik Cho, Seongjae Cho

“…Furthermore, the optimized circuit design results in a high degree of tolerance toward input-current variations arising from conductance-state variations in the synapse array. …”
Get full text

The Use of Probiotics in Gastrointestinal Disease by Karen L Madsen

“…Oral administration of probiotic compounds has been demonstrated to be well tolerated and safe. However, while probiotics have the potential to improve human health and to prevent and treat some diseases, major improvements are needed in labelling and quality assurance procedures for probiotic compounds. …”
Get full text

Analysis of Local Macroeconomic Early-Warning Model Based on Competitive Neural Network by Xiaoxuan Wang, Jingjing Wang, Ying Zhang, Yixing Du

“…Its self-learning and adaptive characteristics and fault tolerance overcome the limitations of the above statistical methods. …”
Get full text

Exploring the perspectives of child health strategy stakeholders on resilience and well-being in children and youths in Singapore: A qualitative study by Yee Keow Chiong, Kee Seng Chia

“… Resilience has been defined as the capacity of a dynamic system to adapt well to potential threats,1 while mitigating the negative impact of behavioural and physiological changes due to chronic stress,2 and the resumption of positive functioning thereafter.3 Resilience enables one to adapt positively to adversities in life and allows the transformation of toxic stress to tolerable stress. The factors associated with resilience are homogeneous across studies, which are individual attributes such as self-regulation and problem-solving skills, relational attributes such as secure attachment relationships, and connections to school and community.4 This is relevant to the Singaporean context, as the Singapore Mental Health Study conducted from 2016 to 2018 revealed that 1 in 5 youths, aged between 18 and 34 years old have a mental disorder.5 Mental disorders were also reported to be the largest contributor to disease burden for Singaporeans aged 10 to 34 years old, peaking for 15 to 19 year-olds, for whom it represented 25.8% of total disability-adjusted life years (DALYs).5 In 2020, suicide is the leading cause of death for those aged 10 to 29 years old. …”
Get full text

Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging by Zhenwei Gong, Radhika H. Muzumdar

“…Aging is a risk factor for impaired glucose tolerance and diabetes. Of the reported 25.8 million Americans estimated to have diabetes, 26.9% are over the age of 65. …”
Get full text

A reliance on human habitats is key to the success of an introduced predatory reptile. by Tom Major, Lauren Jeffrey, Guillem Limia Russel, Rebecca Bracegirdle, Antonio Gandini, Rhys Morgan, Benjamin Michael Marshall, John F Mulley, Wolfgang Wüster

“…Introduced mammal species often use anthropogenic features in their environment and demonstrate a higher tolerance of human disturbance, but their importance remains understudied in ectotherms. …”
Get full text

Quantum memory at nonzero temperature in a thermodynamically trivial system by Yifan Hong, Jinkang Guo, Andrew Lucas

“…Slow Gibbs sampling of such codes enables fault-tolerant passive quantum error correction using finite-depth circuits. …”
Get full text