Proprotein Convertase Subtilisin/Kexin Type 9: From the Discovery to the Development of New Therapies for Cardiovascular Diseases by Nicola Ferri

“…There remains, therefore, an unmet medical need to develop additional well-tolerated and effective agents to lower LDL cholesterol levels. …”
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Generalized Cycle Benchmarking Algorithm for Characterizing Midcircuit Measurements by Zhihan Zhang, Senrui Chen, Yunchao Liu, Liang Jiang

“…Midcircuit measurements (MCMs) are crucial ingredients in the development of fault-tolerant quantum computation. While there have been rapid experimental progresses in realizing MCMs, a systematic method for characterizing noisy MCMs is still under exploration. …”
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Long-Term Evaluation of the Use of the Transdermal Contraceptive Patch in Adolescents by Stephanie Logsdon, Jessica Richards, Hatim A. Omar

“…These results confirmed that the transdermal contraceptive patch is easy to use and an effective method of birth control that may be better tolerated by young women. It also seemed to improve contraceptive compliance in this population.…”
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Comparative Evaluation of Postoperative Incisional Negative Pressure Wound Therapy with Conventional Dressings in Patients of Proximal Tibia Fracture Managed by Dual Plating by Pranav Kothiyal, Kunal Vij, Puneet Gupta

“…Conclusion: With our study, we concluded that in high-velocity proximal tibia fractures with a lot of soft-tissue traumas, incisional NPWT is well tolerated and has shown a definitive advantage in preventing wound-related complications as compared to regular conventional dressing.…”
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Design and experimental characterization of a 350 W High Temperature PEM fuel cell stack by Nicola Zuliani

“…Reactants humidification is not required and CO content up to 2% in the fuel can be tolerated, affecting only marginally performance. This is what makes HT PEM very attractive, as low quality reformed hydrogen can be used and water management problems are avoided. …”
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FAILURE MODES AND EFFECTS ANALYSIS (FMEA) ON TRACK INFRASTRUCTURE INTEGRITY ASSESSMENT by Angga Ahmad Maulana, IGN Wiratmaja Puja, Satrio Wicaksono

“…Then 21 failure modes fall into the "unacceptable" risk level, 4 failure modes fall into the "tolerable" risk level, and 1 failure mode falls into the "acceptable" risk level. …”
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Pseudomembranous Colitis: An Update by Harpreet S Brar, Christina M Surawicz

“…Vancomycin should be reserved for severe cases where metronidazole has failed or where metronidazole cannot be tolerated or is contraindicated. Recurrent C difficile disease is a particularly vexing clinical problem. …”
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L’intégration de la sécurité lors de la conception de machines à risques pour les opérateurs : comparaison de logiques différentes de conception by Cécilia De la Garza

“…Deficiencies in safety will then promote system migration during operation towards less certain areas and lead to accidents or to boundary activities tolerated with use.…”
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Space occupancy in the hallways of old collective housing: a case study of collective housing in Shanghai by Ying Yang, Yinzhe Xu, Kun Liu, Qin Wei

“…In the renewal and daily management of old communities, tolerance and flexibility can be retained for hallway occupancy behavior, which will help to realize the sustainable use of old collective housing and contribute to the preservation of historical urban residencial morphological texture.…”
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Latest news from the bonobos: Pan paniscus myths and realities by David Beaune

“…They are not purely egalitarian but non-violent and tolerant. Neither lethal aggression nor infanticide were observed and are not expected. …”
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Effects of Heliox in Stable COPD Patients at Rest and during Exercise by Matteo Pecchiari

“…On the other hand, when it is administered to COPD patients exercising at a constant work rate, heliox systematically decreases dyspnea sensation, and, often but not always, increases exercise tolerance. For these reasons, heliox has been evaluated as a non pharmacological tool to power rehabilitation programs. …”
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Leftover bandwidth-aware peer selection algorithm for inter-datacenter content distribution by Yong-feng HUANG, Yong-qiang DONG, Shan-feng ZHANG, Guo-xin WU

“…Due to the fact that leftover bandwidth appears during non-overlapping time intervals, an approach of using such bandwidth to distribute delay tolerant data was proposed, and then a distributs and scalable leftover band-width-aware peer selection algorithm named LBAPS was designed. …”
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Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…It has been largely well tolerated, although anemia represents a common on-target side effect and, along with hypoxia, requires monitoring during treatment. …”
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Metastatic SQSTM1-NTRK1 fused non-small-cell lung cancer treated with larotrectinib and stereotactic radiosurgery resulting in durable complete response: a case report by Colton Betts, Ari Kassardjian, Arya Amini

“…The patient has experienced a sustained complete response to treatment almost 3 years later, and he has tolerated the drug without any significant adverse effects. …”
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Improved S-bend optical waveguide loss formula verified by experiments by Ary Syahriar

“…In single mode guides, bending loss becomes significant as the radius of curvature reduces and is strongly dependent on the confinement of the guided mode, so that weakly guiding waveguides can tolerate only large radii of curvature. In this paper we verify our new theoretical version on power loss prediction of S-bend optical waveguides by using analytical theory based on integration of absorption coefficient and compare it to the experimental measurement of such waveguide bends. …”
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Neuroprotection Caused by Hyperoxia Preconditioning in Animal Stroke Models by Mohammad Reza Bigdeli

“…Ischemic tolerance induced by hyperoxia (HO) can protect against brain injury and neurodegenerative diseases. …”
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Grafting in Vegetables: Transforming Crop Production with Cutting-Edge Techniques by Mohsin Raza

“…Vegetable farmers and researchers use grafting as a common technique to increase crop resistance or tolerance to biotic and environmental challenges in a variety of crops, including cucurbitaceous and solanaceous crops. …”
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An Approach for Simple Linear Profile Gauge R&R Studies by Liangxing Shi, Wei Chen, Liang Fu Lu

“…Then, the criteria precision to tolerance ratio and percent R&R are introduced to assess the simple linear profile measurement system capability. …”
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Usages et limites de la violence de guerre à la haute époque hellénistique by Isabelle Pimouguet-Pédarros

“…Did the ongoing struggles and rivalries between the various Greek powers for command of conquered territories lead to a shift in tolerance thresholds? Considering that war violence differs from one space of time to another, this study aims to characterize and identify with precision the acts that fall within its scope, as well as to highlight the way in which these acts are reported by ancient authors and integrated into the narrative of events. …”
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EEG emotion recognition based on parallel separable convolution and label smoothing regularization by Yong ZHANG, Jikui LIU, Wenlong KE

“…In recent years, emotion recognition methods based on deep learning and electroencephalogram (EEG) have achieved good results.However, existing methods still have issues such as incomplete extraction of emotional features from EEG and significant impact from artificially mislabeled emotional labels.A parallel separable convolution and label smoothing regularization (PSC-LSR) network model was proposed.Firstly, through the attention mechanism, EEG important time points and important channels were given greater weight to obtain shallow emotional features of EEG.Secondly, a parallel separable convolution module was used to comprehensively extract EEG emotional information and obtain deep emotional features.Finally, the emotion label smoothing regularization method was used to optimize the model parameters, which increased model’s fault tolerance probability for incorrect labels, enhanced the generalization and robustness of the network model, and improved accuracy of EEG emotion recognition.The proposed method has been validated in two datasets, in which the average accuracy rates of arousal and valence dimensions in the DEAP dataset reaches 99.23% and 99.13%, respectively.In the Dreamer dataset, the average accuracy rates for both arousal and valence dimensions reaches 97.33% and 97.25%.…”
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