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Integrated information theory reveals the potential role of the posterior parietal cortex in sustaining conditioning responses in classical conditioning tasks
Published 2025-01-01“…Classical conditioning is a fundamental associative learning process in which repeated pairings of a conditioned stimulus (CS) with an unconditioned stimulus (US) lead to the CS eliciting a conditioned response (CR). …”
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Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images
Published 2024-12-01“…Collectively, HistoTME presents an effective approach for interrogating the TME and predicting ICI response, complementing PD-L1 expression, and bringing us closer to personalized immuno-oncology.…”
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11243
Interpretation of Recent Unrest Events (Bradyseism) at Campi Flegrei, Napoli (Italy): Comparison of Models Based on Cyclical Hydrothermal Events versus Shallow Magmatic Intrusive E...
Published 2021-01-01“…These similarities have been defined as “bradyseism signatures” that allow us to relate the bradyseism with impending eruption precursors. …”
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Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports
Published 2019-05-01“…We retrieved the individual case safety reports reporting HLH in association with ipilimumab, nivolumab, pembrolizumab, atezolizumab, avelumab or durvalumab, gathered in the database starting from the ICIs’ approval dates by the US Food and Drug Administration. The main outcome measures were co-suspected drugs, concurrent irAEs, HLH clinical, haematological and coagulation features, concomitant infections, HLH median time to onset and outcome.Results Among 49′883 ICI-related ADRs collated in VigiBase as of September 30th, 2018, HLH was reported in 38 cases of which 34 (90%) mentioned ICIs as the solely suspected drugs. …”
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Depth-dependent PD-L1 sampling of head and neck squamous cell carcinoma (HNSCC) – implications for PD-1/PD-L1 checkpoint inhibitor immunotherapy
Published 2024-03-01“…The thickness of each of these tissue blocks allowed us to determine the tumor proportion score (TPS) and combined positive score (CPS) at five depths with adjacent layers separated by 500 μm. …”
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Disease management teams in oncology: State of the art and the experience of a scientific institute of hospitalization and treatment (IRCCS) in Rome, Italy
Published 2025-02-01“…This analysis has allowed us to obtain a useful map of the models used by the different DMTs, also laying the foundations for more precise evaluations of their effectiveness. …”
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Identification of Parkinson’s disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach
Published 2025-02-01“…Our findings enhance understanding of the disease and advance us toward the goal of precision medicine for neurodegenerative disorder.…”
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Clinical and Morphological Features of Dysplasia and Early Gastric Cancer in the Patients with Autoimmune Gastritis
Published 2023-09-01“…The predominance of pseudopyloric metaplasia in the surrounding mucosa allows us to consider pseudopyloric metaplasia as a potentially significant change in the gastric mucosa of patients with AIG that may precede the development of gastric cancer.…”
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African animal trypanocide resistance: A systematic review and meta-analysis
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