Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis by Maria Papathanasiou, Aiste‐Monika Jakstaite, Sara Oubari, Johannes Siebermair, Reza Wakili, Julia Hoffmann, Alexander Carpinteiro, Tim Hagenacker, Andreas Thimm, Christoph Rischpler, Lukas Kessler, Tienush Rassaf, Peter Luedike

“…ATTR type of amyloidosis is the strongest predictor of AF. Prospective screening for occult AF may be considered in ATTR‐CA.…”
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The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention by Yu Shan, Yu Shan, Maoning Lin, Maoning Lin, Fangfang Gu, Duanbin Li, Duanbin Li, Qiongjun Zhu, Qiongjun Zhu, Zhezhe Chen, Zhezhe Chen, Wenbin Zhang, Wenbin Zhang, Guosheng Fu, Guosheng Fu, Min Wang, Min Wang

“…Time-dependent ROC curve demonstrated that the mean TyG index had the strongest predictive ability for MACCE at each follow-up time point. …”
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DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection by Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang

“…All three vaccines elicited robust serum binding and neutralizing antibodies following intramuscular priming and boosting. DS2 induced the strongest antibody responses, followed by SC-TM and DS-Cav1. …”
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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…Abstract Background Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). …”
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Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden by Alexander C. Razavi, Omar Dzaye, Miguel Cainzos-Achirica, Zeina Dardari, Marly Van Assen, Arshed A. Quyyumi, Khurram Nasir, J. Jeffrey Carr, Matthew J. Budoff, Roger S. Blumenthal, Paolo Raggi, Carlo N. De Cecco, Laurence S. Sperling, Michael J. Blaha, Seamus P. Whelton

“…Compared to TAC=0, TAC ≥500 was significantly associated with an increased risk of CVD (HR=1.28, 95% CI: 1.06-1.54) and all-cause mortality (HR=1.44, 95% CI: 1.25–1.65), with the strongest association among persons with CAC=0 (CVD HR=1.79, 95% CI: 1.04–3.07; all-cause mortality HR=1.82, 95% CI: 1.29–2.56). …”
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Lactobacillus fermentum as a new inhibitor to control advanced glycation end-product formation during vinegar fermentation by Qin Li, Leibing Li, Hanjian Zhu, Fan Yang, Ke Xiao, Lin Zhang, Menglin Zhang, Yongsheng Peng, Chao Wang, Dongsheng Li, Qian Wu, Mengzhou Zhou

“…Among 3 strains, Lactobacillus fermentum showed the strongest inhibitory effect on the formation of total fluorescent AGEs and carboxymethyl lysine (CML)/carboxyethyl lysine (CEL) in the fermentation process. …”
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Ultrafast dynamic contrast-enhanced breast MRI with quantitative perfusion parameters in differentiating breast cancer: a study focusing on triple-negative and HER2 positive breast... by Guo Haodong, Zhu Jianguo, Dmytro Pylypenko, Dou Weiqiang, Su Sheng, Xu Jie, Li Haige

“…As per ROC analysis, Ktrans, kep, vp, TTP, and MAX Conc effectively differentiated TNBC from non-TNBC, with TTP being the strongest determinant for TNBC. Furthermore, these parameters successfully distinguished between HER2 positive and HER2 negative, with kep being particularly effective in identifying HER2. …”
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Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan <i>Thymus satureioides</i>, <i>Lavandula angustifolia</i>, and <i>Origanum major... by Amine Elbouzidi, Mohamed Taibi, Naoufal El Hachlafi, Mounir Haddou, Mohamed Jeddi, Abdellah Baraich, Saad Bougrine, Ramzi A. Mothana, Mohammed F. Hawwal, Waleed A. Alobaid, Abdeslam Asehraou, Bouchra El Guerrouj, Hanae Naceiri Mrabti, Francois Mesnard, Mohamed Addi

“…Additionally, <i>L. angustifolia</i> essential oil exhibited the strongest antioxidant activity, with IC₅₀ values of 84.36 µg/mL (DPPH), and 139.61 µg/mL (ABTS), surpassing both the other EOs and standard antioxidants like BHT and ascorbic acid in the ABTS assay. …”
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Structural damage-driven brain compensation among near-centenarians and centenarians without dementia by Hui Tang, Haichao Zhao, Hao Liu, Jiyang Jiang, Nicole Kochan, Jing Jing, Henry Brodaty, Wei Wen, Perminder S. Sachdev, Tao Liu

“…We observed positive correlations between models for brain disconnections and cognitive function in near-centenarians and centenarians. The strongest effects were found between attention and somatomotor network (SMN) (r=0.397, p<0.001), memory and SMN (r=0.333 p<0.001), fluency and visual network (VIS) - control network (CN) (r=0.406, p<0.001), language and VIS (r=0.309, p<0.001), visuospatial ability and VIS-default mode network (DMN) (r=0.464, p<0.001), as well as global cognition and VIS-DMN (r=0.335, p<0.001). …”
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Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…Significantly (p < 0.05), Rubus cuneifolius at a concentration of 0.2 mg/mL exhibited the strongest CYP3A4 inhibition in liver microsomes suggesting its potential as a bioavailability enhancer of CYP3A4 substrates. …”
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Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti... by Gultekin Hasanaliyeva, Ourania Giannakopoulou, Juan Wang, Marcin Barański, Enas Khalid Sufar, Daryl Knutt, Jenny Gilroy, Peter Shotton, Halima Leifert, Dominika Średnicka-Tober, Ismail Cakmak, Levent Ozturk, Bingqiang Zhao, Per Ole Iversen, Nikolaos Volakakis, Paul Bilsborrow, Carlo Leifert, Leonidas Rempelos

“…Specifically, the RDA identified crop protection as a significant driver for Santé but not Sarpo mira, while precipitation was the strongest driver for crop health and yield for Sarpo mira but not Santé. …”
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Biologically targeted discovery-replication scan identifies G×G interaction in relation to risk of Barrett’s esophagus and esophageal adenocarcinoma by Li Yan, Qianchuan He, Shiv P. Verma, Xu Zhang, Ann-Sophie Giel, Carlo Maj, Kathryn Graz, Elnaz Naderi, Jianhong Chen, Mourad Wagdy Ali, Puya Gharahkhani, Xiang Shu, Kenneth Offit, Pari M. Shah, Hans Gerdes, Daniela Molena, Amitabh Srivastava, Stuart MacGregor, Claire Palles, René Thieme, Michael Vieth, Ines Gockel, Thomas L. Vaughan, Johannes Schumacher, Matthew F. Buas

“…In overall and male-specific primary replications, 11 of 187 and 20 of 191 interactions satisfied p < 0.05, respectively. The strongest evidence for secondary replication was for rs17744726×rs3217992 among males, with consistent directionality across all cohorts (Pmeta = 2.19 × 10−8); rs3217992 “T” was associated with reduced risk only in individuals homozygous for rs17744726 “G.” …”
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A fuzzy logic approach within the DPSIR framework to address the inherent uncertainty and complexity of water security assessments by Liang Yuan, Zhijie Zhou, Weijun He, Xia Wu, Dagmawi Mulugeta Degefu, Juan Cheng, Lin Chai, Thomas Stephen Ramsey

“…Responses (R) and water security are positively correlated. (3) The driving force has the strongest positive impact on water security in Laos, while it has a negative impact on Vietnam. …”
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Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study by Maria V. Medeleanu, Maria V. Medeleanu, Myrtha E. Reyna, Myrtha E. Reyna, Darlene L. Y. Dai, Geoffrey L. Winsor, Fiona S. L. Brinkman, Rahul Verma, Ella Nugent, Nashita Riaz, Elinor Simons, Piushkumar J. Mandhane, Piushkumar J. Mandhane, Meghan B. Azad, Meghan B. Azad, Stuart E. Turvey, Stuart E. Turvey, Theo J. Moraes, Theo J. Moraes, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao

“…ObjectiveLower respiratory tract infections (LRTIs) in early life are one of the strongest risk factors for childhood asthma and are often treated with systemic antibiotics (IV or oral). …”
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Effects of Electroacupuncture at Zusanli and Quchi on Neurological Function Recovery in Rats with Cerebral Infarction by Jiangcong HONG, Yingzheng WANG, Guangwen WU, Yulong ZOU

“…The staining was the strongest one day after the cerebral ischemia reperfusion, and the staining range was reduced later. …”
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Association of extreme high temperature weather with non-accidental deaths among residents of Yichang city: a time-stratified case-crossover analysis by Xiaoyan MING, Yang HAN, Zhongcheng YANG, Zaoxia WANG, Shuguang XIE, Chuangang FAN

“…For both male and female subgroups, the effect of P97.5-3 d was strongest at lag day 0, with ORs (95%CI) of 1.36 (1.21 – 1.54) for males and 1.24 (1.08 – 1.43) for females. …”
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A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing by Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps

“…Hepatocellular Carcinoma (HCC) is the most common form of primary liver cancer, with cirrhosis being its strongest risk factor. Interestingly, an increasing number of HCC cases is also observed without cirrhosis. …”
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Critical reflection on the indication for computed tomography: an interdisciplinary survey of risk and benefit management in patients with sepsis by Maria Isabel Opper Hernando, Denis Witham, Ann-Christine Stahl, Peter Richard Steinhagen, Stefan Angermair, Wolfgang Bauer, Friederike Compton, Andreas Edel, Jan Matthias Kruse, York Kühnle, Gunnar Lachmann, Susanne Marz, Holger Müller-Redetzky, Jens Nee, Oliver Paul, Damaris Praeger, Carsten Skurk, Miriam Stegemann, Alexander Uhrig, Stefan Wolf, Myrto Bolanaki, Kerstin Rubarth, Joachim Seybold, Elke Zimmermann, Marc Dewey, Julian Pohlan

“…Most physicians agreed that the benefits of CT outweigh its potential adverse effects in septic patients (90.5%, n = 336/371). Responders saw the strongest indication for contrast media administration in septic patients for (1) CT examinations of the abdomen (92.7%, n = 333/359) and (2) combined CT examinations of the chest, abdomen, and pelvis (94.1%, n = 337/358). …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Integrative network analysis of apolipoproteins and their correlates/determinants revealed both shared and specific associations, with the strongest relationships observed among apolipoproteins, cholesterol, triglycerides, alpha tocopherol, and GlycA (Padj < 0.05). …”
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Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta... by Leiling Liu, Zhiqi Li, Wenrui Ye, Pu Peng, Yurong Wang, Luqing Wan, Jiangnan Li, Mei Zhang, Yihua Wang, Runqi Liu, Danyan Xu, Jingjing Zhang

“…Tirzepatide had the strongest antihypertensive effect on both systolic (WMD −5.74, −9.00 to −2.48; P = 0.0006; I2 = 99.8%; moderate certainty) and diastolic blood pressure (WMD −2.91, −4.97 to −0.85; P = 0.0056; I2 = 99.8%; moderate certainty) and best reduced triglycerides (WMD −0.77, −0.85 to −0.69; P < 0.0001; I2 = 3.2%; high certainty), fasting glucose (WMD −3.06, −5.53 to −0.59; P = 0.015; I2 = 100.0%; moderate certainty), insulin (WMD −4.91, −8.15 to −1.68; P = 0.0029; I2 = 97.0%; moderate certainty), and glycated haemoglobin levels (WMD −1.27, −1.82 to −0.73; P < 0.0001; I2 = 100.0%; moderate certainty). …”
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