Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…The SHAP, ELI5, and XGBoost feature importance analysis demonstrates that the S/F ratio ranks as the strongest predictor for mortality amongst the physiologic variables. …”
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Laboratory Measurement of CH317OH Transitions in the Frequency Range from 216 to 264 GHz for Astronomical Application by Akemi Tamanai, Takahiro Oyama, Yoshimasa Watanabe, Takeshi Sakai, Riouhei Nakatani, Shaoshan Zeng, Isabelle Kleiner, Nami Sakai

“…We have specifically paid attention to the Q -branch transitions, which are the strongest line series in this frequency region. Among the stable oxygen isotopes, ^16 O, ^17 O, and ^18 O of methanol, only ^12 CH _3 ^17 OH obviously shows line profiles having double and/or triple peaks in low- J transitions, due to the nuclear quadrupole interaction. …”
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Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism by Andrea Fumagalli, Anna Castells-Nobau, Dakshat Trivedi, Josep Garre-Olmo, Josep Puig, Rafel Ramos, Lluís Ramió-Torrentà, Vicente Pérez-Brocal, Andrés Moya, Jonathan Swann, Elena Martin-Garcia, Rafael Maldonado, José Manuel Fernández-Real, Jordi Mayneris-Perxachs

“…Interestingly, methanogen archaeas exhibited the strongest positive associations with cognition, particularly Methanobrevibacter smithii (M. smithii). …”
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Analysis of the long-range transport of the volcanic plume from the 2021 Tajogaite/Cumbre Vieja eruption to Europe using TROPOMI and ground-based measurements by P. Hedelt, J. Reichardt, F. Lauermann, B. Weiß, N. Theys, A. Redondas, A. Barreto, O. Garcia, D. Loyola

“…In particular, the spectrometric fluorescence and Raman lidar for atmospheric moisture sensing (RAMSES) at the Lindenberg Meteorological Observatory measured the plume of the strongest Tajogaite eruption of 22–23 September 2021 over northeastern Germany 4 d later. …”
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Relationship between bacteria and nitrogen dynamics in wastewater treatment oxidation ponds by S. Saneha, T. Pattamapitoon, S. Bualert, O. Phewnil, W. Wararam, N. Semvimol, K. Chunkao, C. Tudsanaton, M. Srichomphu, U. Nachaiboon, O. Wongsrikaew, P. Wichittrakarn, C. Chanthasoon

“…Fifteen bacterial phyla were identified in the five oxidation ponds, with phylum Proteobacteria accounting for the highest population comprising 47.56% of the total bacterial population.CONCLUSION: Genera Novosphingobium (phylum Proteobacteria), Ammonia-11 (phylum Verrucomicrobiota), and Vicinamibacteraceae (phylum Acidobacteriota) have the strongest relationships with ammonia, nitrate, and total kjeldahl nitrogen (R2 = 0.9710, 0.986, 0.8124). …”
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Associations between exposure to volatile organic compounds with obesity in adults by Runmiao Wu, Lei Jia, Xu Zhu, Gongchang Guan, Junkui Wang, Rutai Hui, Meijuan Ma, Zhao Zhao, Hui Pang, Ling Zhu

“…Additionally, Qgcomp regression analysis revealed a significant negative correlation between the mixture of urine VOC metabolites and all obesity-related outcomes, with 2HPMA demonstrating the strongest influence on this negative association. Conclusion: Our findings suggest a negative relationship between exposure to VOCs, as measured by urine VOC metabolite levels, and obesity in adults.…”
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Workload-capacity imbalances and their impact on self-management complexity in patients with multimorbidity: a multicenter cross-sectional study by Binyu Zhao, Yujia Fu, Jingjie Wu, Erxu Xue, Chuyang Lai, Dandan Chen, Qiwei Wu, Jianing Yu, Qiaoyu Wu, Zhihong Ye, Jing Shao

“…Social capacity was the strongest predictor for all profiles. Environmental capacity ranked second for ‘high workload-high capacity’ (R² = 3.26) and ‘low workload-low capacity’ (R² = 5.32) profiles. …”
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Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…Meanwhile, the combined protein group showed the strongest ability to detect Brucella in sheep serum, achieving an accuracy of 88.10%. …”
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Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor by Elias Leiva-Salcedo, Claudio Coddou, Felipe E. Rodríguez, Antonello Penna, Ximena Lopez, Tanya Neira, Ricardo Fernández, Mónica Imarai, Miguel Rios, Jorge Escobar, Margarita Montoya, J. Pablo Huidobro-Toro, Alejandro Escobar, Claudio Acuña-Castillo

“…The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced responses. …”
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Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from <i>Cinnamomum cassia</i> Leaves by Yanrong Cheng, Ying Fu, Dingze Gu, Yan Huang, Yongqi Lu, Yujie Liu, Xiulan Li, Xinyue Yao, Xinxuan Zhang, Wanying Jian, Peiwei Liu, Hong Wu, Yanqun Li

“…<i>C. cassia</i> leaf oil demonstrated the strongest antibacterial activity, with a minimum inhibitory concentration (MIC) of 0.25 mg/mL against <i>S. aureus</i> and <i>L. monocytogenes</i> for the spring oil. …”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

“…Among all subsets, the number of Ly6c+ macrophages exhibited the strongest correlation with severity of histologic liver injury by Ishak score.ConclusionsOur data identify specific pathways upregulated in Ly6c vs MHCII+ macrophage subsets in murine BA. …”
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The James Webb Space Telescope Absolute Flux Calibration. III. Mid-infrared Instrument Medium Resolution Integral Field Unit Spectrometer by David R. Law, Ioannis Argyriou, Karl D. Gordon, G. C. Sloan, Danny Gasman, Alistair Glasse, Kirsten Larson, Leigh N. Fletcher, Alvaro Labiano, Alberto Noriega-Crespo

“…This calibration is complicated by a time-dependent evolution in the effective throughput of the MRS; this evolution is strongest at long wavelengths, approximately a factor of 2 at 25 μ m over the first 2 yr of the mission. …”
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Real world pharmacovigilance assessment of drug related macular degeneration risks by Xiaodong Chen, Shinan Wu, Shaopan Wang, Chaofeng Yu, Zihan Guo, Shiya Huang, Peixin Cai, Yanliang Miao, Shiying Li, Qian Chen

“…The BCPNN algorithm revealed that 45.2% (19/42) of these drugs had the strongest associations with macular degeneration, with pentosan polysulfate sodium, travoprost, and tolterodine being the highest-risk drugs. …”
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Epidemiology, Risk Factors, and Predictors of Disability in a Cohort of Jordanian Patients with the First Ischemic Stroke by Majdi Al Qawasmeh, Belal Aldabbour, Aiman Momani, Deema Obiedat, Kefah Alhayek, Raid Kofahi, Ahmed Yassin, Khalid El-Salem

“…Regarding predictors of prognosis, current smoking status, age above 50, gender, and NIHSS on admission appear to be the strongest predictors of prognosis. Finally, higher NIHSS score on admission resulted in a longer hospital stay.…”
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Flowering characteristics and breeding system of Deutzia parviflora by WANG Qi, LI Jinyu, WANG Xinyi, WANG Yixuan, GUO Wei, YUAN Tao

“…Its flowering type is concentrated flowering, with a group flowering period of 22-23 d and a single flowering period of 8 d, which can be divided into 8 stages. (2) The stigma acceptability at the petal flattening stage was the strongest, and the pollen viability at the stamen expansion stage was the highest. (3) The optimal medium for pollen viability determination was: 100.0 g/L sucrose + 0.3 g/L H3BO3 + 0.2 g/L CaCl2. (4) Pollen can be dried and stored in the short term (within 10 d), at -20 ℃ and -80 ℃ in the medium term (10-30 d), and at -80 ℃ for a long time (more than 30 d). (5) The pollen-ovule ratio of D . parviflora was 23 695.93, the out-crossing index was 3, the fruit setting rate of xenogamy was the highest. …”
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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

“…We then investigated the impact of single intramyocardial IL-10 administration on cardiac function, structure, and inflammation post-MI, using a mouse MI model.ResultsCompared with 0-ng/mL control, 250-ng/mL IL-10 had the strongest overall effects in decreasing M1 and increasing M2 phenotypes on polarized Mφ while ≥500-ng/mL IL-10 dampened M1 polarization and augmented native IL-10 secretion more effectively than low doses in vitro. …”
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Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Paul Dowling, Simone Marcone, Caitriona Scaife, Elaine M. Kenny, Michael Henry, Paula Meleady, Paul F. Ridgway, Finbar MacCarthy, Kevin C. Conlon, Barbara M. Ryan, Stephen G. Maher

“…A 13-feature multi-omic panel in serum [SHROOM3, IGHV3-72, IGJ, IGHA1, PPBP, APOD, SFN, IGHG1, miR-197-5p, miR-6741-5p, miR-3180, miR-3180-3p, miR-6782-5p] produced an AUC = 0.824. Integration of the strongest performing biomarkers generated a 10-feature cross-biofluid multi-omic panel [S100A8, LGALS3, SNORA66, miR-216b-5p, IGHV3-72, IGJ, IGHA1, PPBP, miR-3180, miR-3180-3p] with an AUC = 0.970. …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…More than 1,200 miRNAs were assayed for putative protective effects in light-stressed 661W photoreceptor-like cells, and the top-performing miRNAs were further validated in independent in vitro assays. miR-429 showed the strongest cell-protective effect in vitro. Adeno-associated viral vector-mediated subretinal delivery of miR-429 in the RhoP23H/+ IRD mouse model preserved electrophysiological responses and was associated with reduced inflammatory processes in the retina. …”
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Spatiotemporal Variations in Compound Extreme Events and Their Cumulative and Lagged Effects on Vegetation in the Northern Permafrost Regions from 1982 to 2022 by Yunxia Dong, Guimin Liu, Xiaodong Wu, Lin Wang, Haiyan Xu, Sizhong Yang, Tonghua Wu, Evgeny Abakumov, Jun Zhao, Xingyuan Cui, Meiqi Shao

“…Notably, extreme high temperature–precipitation compound events exhibit the strongest cumulative and lagged effects on vegetation, while extreme low temperature–drought compound events influence wetland and shrubland areas within the same month. …”
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Changes in alcohol consumption among Belgian adults participating in the internet-based one-month-abstinence campaign ‘Tournée Minérale’ by Annelies Thienpondt, Jelle Van Cauwenberg, Joris Van Damme, Gera E. Nagelhout, Benedicte Deforche

“…Higher level drinkers appear to be especially attracted to participate in TMC and to experience the strongest decreases in alcohol consumption. However, without comparison with a control group of non-participants or comparison points, we cannot simply attribute the changes over time to participation in TMC. …”
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