Antioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP. by Zheng-Qiang Li, Yu-Ting Gao, Chen-Fa Zhao, Rui An, Yan-Lv Wu, Zhi-Pang Huang, Ping Ma, Xu Yang, Rong She, Xiao-Yan Yang

“…Compared to other extractants (ethyl acetate, n-butanol, 75% ethanol, and petroleum ether), WNGH-AE exhibited the strongest free radical scavenging ability. Through LC-MS/MS analysis, we identified 403 compounds in WNGH-AE, with gentisic acid being the most abundant and possessing high antioxidant capacity, suggesting it may be a key active component contributing to the antioxidant activity of WNGH-AE. …”
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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

“…With IC50 values of 2.49 ± 1.9, 1.56 ± 1.3, and 2.97 ± 2.6 μM against Caco-2, HCT116, and A549 cell lines, respectively, compound 7f demonstrated the strongest anticancer properties among all synthesised compounds when compared to the conventional medication doxorubicin (IC50 = 3.10 to 3.32 μM). …”
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Increasing Number and Proportion of Adverse Obstetrical Outcomes among Women Living with HIV in the Ottawa Area: A 20-Year Clinical Case Series by Sarah Buchan, Katherine A. Muldoon, Johanna N. Spaans, Louise Balfour, Lindy Samson, Mark Walker, D. William Cameron

“…Psychiatric illness (AOR: 2.64, 95% CI: 1.12–6.24), teen pregnancy (AOR: 3.35, 95% CI: 1.04–1.46), and recent immigrant status (AOR: 7.24, 95% CI: 1.30–40.28) were the strongest correlates of adverse obstetrical outcomes. …”
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Perception of antibiotic use and antibiotic resistance among faculty and staff in a medical school: insights from a mixed mode survey in Bahrain by Ronni Mol Joji, Archana Prabu Kumar, Amer Almarabheh, Ali Al-Mahmeed, Mohd Shadab, Khalid Bindayna, Mohammad Shahid

“…The in-depth interviews revealed that the faculty group had the strongest basic knowledge about antibiotics and resistance. …”
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Colder temperatures augment viability of an indirectly transmitted songbird pathogen on bird feeders by Sara R. Teemer, Edan R. Tulman, Alicia G. Arneson, Steven J. Geary, Dana M. Hawley

“…Further, MG was significantly more pathogenic when incubated on feeders in colder versus warmer temperatures, with the strongest effects of temperature present after at least four days of incubation on feeder surfaces. …”
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A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 5 – Surgical and Injection-Based Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…The evidence is not yet strong enough to establish the effectiveness of any of these treatments; of all the invasive interventions for chronic WAD, radiofrequency neurotomy appears to be supported by the strongest evidence. Further research is required to determine the efficacy and the role of invasive interventions in the treatment of chronic WAD.…”
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The combined impact of BMI and ABSI on all-cause mortality among American adults with diabetes by Shuwu Wei, Weimin Jiang, Huijuan Zheng, Jiale Zhang, Jie Yang, Yaoxian Wang, Yang Liu, Liqiao Sun, Xinrong Li, Junping Wei, Weiwei Sun

“…Results Among all the anthropometric indices, ABSI exhibited the strongest independent association with all-cause mortality, outperforming other measures such as BMI, WHtR, BRI, and Conicity Index. …”
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Polypharmacy and anticholinergic burden scales in older adults: a cross-sectional study among psychiatric outpatients in a tertiary care hospital by Manjunath Bidarolli, Biswadeep Das, Vikram Singh Rawat, Sachin Manocha, Hannah Theresa Sony, Akash Agnihotri, Mahima Gupta, Franklin Agera

“…Univariate analysis demonstrated that all anticholinergic risk assessment scales were closely correlated with polypharmacy, with the strongest association observed for the Anticholinergic Load Scale (ALS) (Odds Ratio = 4.3; p < 0.001). …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…The surface-exposed VirG53 – 353 subregion of the passenger α-domain demonstrated the highest and strongest immunoreactivity. VirG53 – 353 was produced efficiently at a large scale (>150 mg/L) using cell-free protein synthesis. …”
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Network analysis of the association between social anxiety and problematic smartphone use in college students by Wanying Xing, Xianyang Wang, Tingwei Feng, Jiaxin Xie, Chang Liu, Xiuchao Wang, Hui Wang, Lei Ren, Lei Ren, Xufeng Liu

“…Notably, the connections between ‘Get embarrassed very easily’ (SA3) and ‘shyness in new situations’ (PSU1), as well as between SA3 and ‘Escape or relieve negative moods’ (PSU8), showed the strongest inter-construct connections. SA3 and PSU8 were identified as the key symptoms contributing to the co-occurrence, with the highest BEI. …”
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Evaluation of the Synergistic Antimicrobial Activity of Essential Oils and Cecropin A Natural Peptide on Gram-Negative Bacteria by Filippo Fratini, Chiara Pecorini, Ilaria Resci, Emma Copelotti, Francesca Paola Nocera, Basma Najar, Simone Mancini

“…The MIC results showed that winter savory EO (<i>Sm</i>EO) and cinnamon EO (<i>Cz</i>EO) exhibited the strongest antibacterial activity against both bacterial strains, whereas bergamot EO (<i>Cb</i>EO) and CecA demonstrated comparatively lower antibacterial efficacy. …”
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COVID-19 vaccine uptake in Skåne county, Sweden, in relation to individual-level and area-level sociodemographic factors: a register-based cross-sectional analysis by Per-Olof Östergren, Louise Bennet, Jonas Björk, Adam Mitchell, Mahnaz Moghaddassi, Malin Inghammar

“…The predicted proportion vaccinated increased with more affluent socioeconomic conditions and concurrent increases in individual household income were the strongest indicators. This sociodemographic selection showed consistency with respect to entering (obtaining ≥2 doses) and remaining (obtaining at least one booster dose) in the vaccination programme.…”
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Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017–2020 by Ji Li, Shou-jun Bai

“…Subgroup analysis found the strongest association among females, individuals aged 20–39, non-Hispanic Whites, those without a history of coronary heart disease, and alcohol consumers. …”
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Anti-obesity effects of Erythrina abyssinica stem bark extract in flies exposed to a high fat diet by Oscar Hilary, Asiimwe, Eddie, Wampande, John, Rubaihayo, Keneth Iceland, Kasozi, Hellen, Wambui Kinyi

“…Results: Fly survival changes were observed after 10 days and E. abyssinica stem bark extract had the strongest reducing power at 7.5 g/ml extract concentration. …”
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Compound exposure of 2.8 GHz and 9.3 GHz microwave causes learning and memory impairment in rats by Liu Sun, Xiaoya Wang, Ke Ren, Chuanfu Yao, Haoyu Wang, Xinping Xu, Hui Wang, Ji Dong, Jing Zhang, Binwei Yao, Xiaohui Wei, Ruiyun Peng, Li Zhao

“…Importantly, compound microwave produced strongest responses at 3 d after exposure. Moreover, microwave also could induce abnormal electroencephalogram (EEG), such as increasing the power of θ wave and δ wave, suggesting brain damage or dysfunction. …”
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Understanding spatiotemporal changes and influencing factors in the habitat quality of coastal waters: A case study of Jiangsu Province, China (2006–2020) by Zhou Chen, Yanjing Chen, Haifeng Zhang, Hong Zhang, Min Xu

“…The Plankton Diversity Index (PDI) had the strongest positive impact on coastal waters habitat quality between 2006 and 2010, whereas environmental pollution-related factors, and HA had the least impact. …”
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Identification of natural compound inhibitors for substrate-binding site of MTHFD2 enzyme: Insights from structure-based drug design and biomolecular simulations by Nisarg Rana, Priyanka Solanki, Rukmankesh Mehra, Anu Manhas

“…MM/PBSA free energy calculations supported these findings, with C3 (-33.26 kcal/mol) and C6 (-32.11 kcal/mol) displaying the strongest binding energies, while C5 (-20.59 kcal/mol) exhibited moderate binding affinity. …”
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Housing Price Forecasting Using AI (LSTM) by Hossein Ziyadi, Erfan Salavati, Mohammad Mahdi Lotfi Heravi

“…Our findings indicate that the average housing price demonstrates the strongest correlation with gold prices, foreign exchange rates, the Consumer Price Index, and market liquidity levels. …”
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Prevalence and Determinants of Hypertension Awareness, Treatment, and Control in Botswana: A Nationally Representative Population-Based Survey by Neo M. Tapela, Lei Clifton, Gontse Tshisimogo, Moagi Gaborone, Tebogo Madidimalo, Virginia Letsatsi, Tiny Masupe, Mosepele Mosepele, Joseph Makhema, Shahin Lockman, David J. Hunter

“…A fifth of hypertensives who were diagnosed but not on medications had BP ≥ 180/110 mmHg. Diabetes was the strongest correlate of hypertension and awareness (aOR 4.00, 1.86–8.59; aOR 3.30, 1.44–7.55, respectively). …”
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Effect of ionic strength and mixing ratio on complex coacervation of soy protein isolate/Flammulina velutipes polysaccharide by Junmiao Zhang, Hengjun Du, Ning Ma, Lei Zhong, Gaoxing Ma, Fei Pei, Hui Chen, Qiuhui Hu

“…SPI/FVP coacervates exhibited solid-like properties and presented the strongest storage modulus at CNaCl = 50 mmol/L. The optimal pH, SPI/FVP ratio and NaCl concentration of complex coacervation were collected, and the coacervates demonstrated a valuable application potential to protect and deliver bioactives and food ingredients.…”
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