A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare databaseResearch in context by Floriane Jochum, Madeleine Doll, Anne-Sophie Hamy, Lou Donval, Paul Gougis, Élise Dumas, Lise Lecointre, Thomas Gaillard, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Enora Laas

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Transforming Non-Digital, Clinical Workflows to Detect and Track Vision-Threatening Diabetic Retinopathy via a Digital Platform Integrating Artificial Intelligence: Implementation... by Peranut Chotcomwongse, Paisan Ruamviboonsuk, Chaiwat Karavapitayakul, Koblarp Thongthong, Anyarak Amornpetchsathaporn, Methaphon Chainakul, Malee Triprachanath, Eckachai Lerdpanyawattananukul, Niracha Arjkongharn, Varis Ruamviboonsuk, Nattaporn Vongsa, Pawin Pakaymaskul, Turean Waiwaree, Hathaiphan Ruampunpong, Richa Tiwari, Viroj Tangcharoensathien

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PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

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Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease by Aaron King, Xi Tan, Neil Dhopeshwarkar, Rhonda Bohn, Katherine Dea, Charles E. Leonard, Adam de Havenon

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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

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Efficacy of personalized feedback in encouraging sustainable washing behavior: evidence from a pilot study in Germany by Laura Höpfl, Laura Höpfl, Laura Höpfl, Ivan Đula, Ivan Đula, Ivan Đula, Francisco Kiss, Rebecca Walter, Maria Wirzberger, Maria Wirzberger, Maria Wirzberger

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On the current and future potential of simulations based on directed acyclic graphs by Lutz P. Breitling, Anca D. Dragomir, Chongyang Duan, George Luta

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Changes in nutritional management after gastrointestinal cancer surgery over a 12-year period: a cohort study using a nationwide medical claims database by Yoshikuni Kawaguchi, Kenta Murotani, Nahoki Hayashi, Satoru Kamoshita

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Treatment Inertia and Symptom Burden in Anemia of CKD: Insights from the SATISFY Survey in the Middle East, South Africa, and Türkiye by Arici M, Al-Ghamdi SMG, Assounga AG, El-Koraie AF, McMillan A, Camidge LJ, Sumarsono B, Blogg M, Ng DB, Lansang EP

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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s disease by Chitra Karki, Gary Hantsbarger, Erika Turkstra, Elisabetta Fenu, Ken Genenz, Inmaculada Gilaberte, Julián Panés

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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis of the Reiwa Study by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). The real‐world time to treatment failure (rwTTF) was 7.3 months. …”
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PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority adolescents in Brazil by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

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Real world data on outcomes of anti-CD38 antibody treated, including triple class refractory, patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma Research Group (CMRG) Database by A. Visram, A. De La Torre, D. White, J. Su, E. Masih-Khan, M. Chu, V. Jimenez-Zepeda, A. McCurdy, R. LeBlanc, K. Song, H. Mian, M. Louzada, M. Sebag, D. Bergstrom, J. Stakiw, A. Reiman, R. Kotb, M. Aslam, C. Venner, R. Kaedbey, E. Gul, D. Reece

“…Our results reinforce that real-world patients with relapsed MM, particularly those with TCR disease, have dismal outcomes. …”
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In Shift and In Variance: Assessing the Robustness of HAR Deep Learning Models Against Variability by Azhar Ali Khaked, Nobuyuki Oishi, Daniel Roggen, Paula Lago

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Statistical analysis of stress–strength in a newly inverted Chen model from adaptive progressive type-Ⅱ censoring and modelling on light-emitting diodes and pump motors by Refah Alotaibi, Mazen Nassar, Zareen A. Khan, Ahmed Elshahhat

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MOANA: Multi-objective ant nesting algorithm for optimization problems by Noor A. Rashed, Yossra H. Ali, Tarik A. Rashid, Seyedali Mirjalili

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Treatment patterns and clinical profile in progressive pulmonary fibrosis: a Japanese cross-sectional survey by Hidekata Yasuoka, Yuko Waseda, Yuko Kaneko, Masateru Okazaki, Ryoko Iwasaki, Shoko Nagata, Mark Small, Haruyuki Ishii

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A dataset for large prismatic lithium-ion battery cells (CALB L148N58A): Comprehensive characterization and real-world driving cyclesCALB L148N58A testing campaign by Simone Fasolato, Nicola Blasuttigh, Giacomo Galuppini, Davide M. Raimondo

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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…Introduction Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over the last decade with the emergence of cardioprotective novel agents, but without such data for older drugs, leaving a critical gap in our understanding of the relative effects of T2DM agents on cardiovascular risk.Methods and analysis The large-scale evidence generations across a network of databases for T2DM (LEGEND-T2DM) initiative is a series of systematic, large-scale, multinational, real-world comparative cardiovascular effectiveness and safety studies of all four major second-line anti-hyperglycaemic agents, including sodium–glucose co-transporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, dipeptidyl peptidase-4 inhibitor and sulfonylureas. …”
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Unlocking autism’s complexity: the Move Initiative’s path to comprehensive motor function analysis by Ashley Priscilla Good, Elizabeth Horn

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