Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…PBC is organ-specific autoimmune liver disease affecting predominantly women that is characterized by chronic progressing destruction of intrahepatic bile ducts with portal inflammation, resulting in development of liver cirrhosis (LC). …”
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Integrals at secondary school by Antanas Anynis, Juozas Šinkūnas

“… Teaching of integrals in Lithuania, Denmark and France is presented. It is suggested to progress to three levels teaching of mathematics. …”
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Sustainable Development in the Digital Age: Harnessing Emerging Digital Technologies to Catalyze Global SDG Achievement by Claudiu George Bocean

“…The digital revolution, characterized by rapid technological advancements, presents a unique opportunity to accelerate progress towards the United Nations’ Sustainable Development Goals (SDGs). …”
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Genetic and molecular mechanisms of hydrocephalus by Xuehai Deng, Xuehai Deng, Yiqian Chen, Yiqian Chen, Qiyue Duan, Qiyue Duan, Jianlin Ding, Jianlin Ding, Zhong Wang, Zhong Wang, Junchi Wang, Xinlong Chen, Liangxue Zhou, Long Zhao

“…In the past 50 years, the diagnosis and treatment of hydrocephalus have remained understudied and underreported, and little progress has been made with respect to prevention or treatment. …”
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Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis by Min-Na Zhang, Ran Duan, Gui-Hong Chen, Mei-Jun Chen, Chun-Gu Hong, Xin Wang, Zhi-Lin Pang, Chun-Yuan Chen, Hua-Feng Liu, Da Zhong, Hui Xie, Wen-Bao Hu, Zheng-Zhao Liu

“…Furthermore, fasting prevented OA progression by activating OPTN-mediated mitophagy and maintaining mitochondrial homeostasis in mice. …”
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Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer by Jarupa Soongsathitanon, Pranisa Jamjuntra, Nuttavut Sumransub, Supaporn Yangngam, Marjorie De la Fuente, Glauben Landskron, Peti Thuwajit, Marcela A. Hermoso, Chanitra Thuwajit

“…Signals from the tumor microenvironment (TME) have a profound influence on the maintenance and progression of cancers. Chronic inflammation and the infiltration of immune cells in breast cancer (BC) have been strongly associated with early carcinogenic events and a switch to a more immunosuppressive response. …”
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Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Many studies have reviewed the progress of synaptic density imaging; however, to our knowledge, there is no article yet that summarizes the research progress of multimodal imaging of synaptic density tracers combined with other dementia biomarkers. …”
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Exosome-Derived microRNA: Potential Target for Diagnosis and Treatment of Sepsis by Yujie Xiao, Yixuan Yuan, Dahai Hu, Hongtao Wang

“…Sepsis, a severe systemic response to infection, involves intricate immune and nonimmune mechanisms, where exosome-mediated communication can significantly influence disease progression and outcomes. During the progress of sepsis, the miRNA profile of exosomes undergoes notable alterations, is reflecting, and may affect the progression of the disease. …”
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MicroRNAs in Diabetic Kidney Disease by Rong Li, Arthur C. K. Chung, Xueqing Yu, Hui Y. Lan

“…Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. …”
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Stathmin 1 expression in neuroendocrine and proliferating prostate cancer by Yingli Shi, Yunshin A. Yeh, Siyuan Cheng, Xin Gu, Shu Yang, Lin Li, Nazih P. Khater, Susan Kasper, Xiuping Yu

“…While PCa initially responds to androgen deprivation therapy, a significant portion progresses to castration-resistant PCa. Approximately 20–25% of these cases acquire aggressive neuroendocrine (NE) features, ultimately leading to neuroendocrine prostate cancer (NEPC). …”
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Constitutional Legislation Developments in the Russian Federation for Sustainable Development Goals by V. P. Kirilenko, G. V. Alekseev

“…The improvement of constitutional legislation at the national level is impossible without taking into account the progressive transformations in the international system that predetermine progress in solving the political problems of our time. …”
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Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…It is the most common cause of progressive memory loss (dementia) in the elderly, and to date, there is no effective treatment to cure or slow disease progression substantially. …”
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Silent enemy of the hand: The Viking disease by Stoiljković Vera

“…Dupuytren's contracture (DK) is the most common progressive idiopathic fibrosis of the superficial palmar fascia, often asymptomatic at its onset, caused by changes in the palmar aponeurosis, resulting in flexion contractures in the fingers of the hand. …”
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The Role of the Immune System in Huntington’s Disease by Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A. Linker

“…Huntington’s disease (HD) is characterized by a progressive course of disease until death 15–20 years after the first symptoms occur and is caused by a mutation with expanded CAG repeats in the huntingtin (htt) protein. …”
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Trends in Survival for Adult Organ Transplantation by Grant Patrick, BS, Brian Hickner, MD, Karthik Goli, BS, Liam D. Ferreira, MBA, John Goss, MD, Abbas Rana, MD

“…Intent-to-treat analysis follows patients from listing to death, regardless of their transplant status, and aims to provide a more holistic scope of the progress made in adult solid-organ transplantation. …”
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Propensity score matched comparison of lymph node upstaging in early-stage lung cancer: open versus minimally invasive surgery with standardized lymphadenectomy by Julia Zimmermann, Julia Walter, Valentina Pfeiffer, Julia Kovács, Gökçe Yavuz, Johannes Schön, Mircea Gabriel Stoleriu, Christian Ketscher, Niels Reinmuth, Rudolf A. Hatz, Amanda Tufman, Christian P. Schneider

“…Multivariate Cox regression analysis showed that overall survival and progression free survival were also independent of the surgical approach. …”
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Epidemiological, clinical and imaging profile of Multiple Sclerosis by Làzaro Aurelio Vàzquez Gòmez, Carlos Hidalgo Mesa, Benita Mabel Beltrán González, Yunier Broche Pérez, Ana María Mederos Herrera

“…It was found that 59 patients had a relapsing-remitting clinical form, 21 patients had a secondary progressive form, 4 patients had a primary progressive and 2 patients had a relapsing progressive one. …”
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Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD by Songyuan Yang, Zehua Ye, Lijia Chen, Xiangjun Zhou, Wei Li, Fan Cheng

“…Thus, implementing early interventions to halt the progression from AKI to CKD has the potential to markedly improve patient outcomes. …”
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Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver by M. Del Ben, L. Polimeni, F. Baratta, S. Bartimoccia, R. Carnevale, L. Loffredo, P. Pignatelli, F. Violi, F. Angelico

“…Hepatocyte apoptosis may play a role in progression of nonalcoholic fatty liver and oxidative stress seems one of the key mechanisms responsible for liver damage. …”
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Case report: Toxic epidermal necrolysis as a unique presentation of acute graft versus host disease in a pediatric patient by Elizabeth Marlowe, Rachel Palmer, April L. Rahrig, Devin Dinora, Jessica Harrison, Jodi Skiles, Mahvish Q. Rahim

“…Severe presentations of skin aGVHD involving rapid progression of rash to bullae formation and mucosal involvement are rare. …”
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