Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…To present literature data on the metabolic and genetic mechanisms of impaired fatty acid (FA) synthesis in the development and progression of non-alcoholic fatty liver disease (NAFLD).General findings. …”
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Treatment of Advanced Hepatocellular Carcinoma after Failure of Sorafenib Treatment: Subsequent or Additional Treatment Interventions Contribute to Prolonged Survival Postprogressi... by Masaaki Kondo, Kazushi Numata, Koji Hara, Akito Nozaki, Hiroyuki Fukuda, Makoto Chuma, Shin Maeda, Katsuaki Tanaka

“…Furthermore, interventions consisting of other treatment options upon the appearance of progression might prolong OS.…”
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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial by Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob P. Laubach, Giada Bianchi, Elizabeth O’Donnell, Ting Wu, Junko Tsuji, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

“…The primary endpoint, median progression-free survival (PFS), was not reached (NR) (95% CI: 57.7–NR, median follow-up 50 months). …”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. The prevalences of ESR1 and RB1 alterations significantly increase in post-progression samples. …”
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Case report: A rare case of a long-term survivor of glioblastoma who underwent two courses of hypofractionated radiotherapy as part of her care by Midhad Mrvoljak, Midhad Mrvoljak, Shubhendu Mishra, Liam Chen, Liam Chen, Elizabeth Neil, Elizabeth Neil, Eric Ehler, Stephanie Terezakis, Stephanie Terezakis, Lindsey Sloan, Lindsey Sloan

“…After recurrence, another HFRT (35 Gy in 10 fractions) was employed. She was progression-free on imaging for 8 months until a recent follow-up scan showed potential progression versus radiation-related change. …”
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Modelling of Time-Dependent Wellbore Collapse in Hard Brittle Shale Formation under Underbalanced Drilling Condition by Shanpo Jia, Zhiqiang Xiao, Bisheng Wu, Caoxuan Wen, Lufeng Jia

“…Then the coupled HMC model is applied to simulate the progressive evolution process of wellbore collapse in a hard brittle shale formation, and the influence of different parameters on the progressive failure of the wellbore is analysed. …”
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Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice by Kenichi Nakajima, Tomoya Mita, Yusuke Osonoi, Kosuke Azuma, Toshiyuki Takasu, Yoshio Fujitani, Hirotaka Watada

“…However, the effects of repetitive postprandial glucose spikes, repetitive hypoglycaemia, and their combination on the progression of atherosclerosis remain largely unknown. …”
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Evolutionary Algorithms and Quantum Computing: Recent Advances, Opportunities, and Challenges by Junaid Ur Rehman, Muhammad Shohibul Ulum, Abdurrahman Wachid Shaffar, Amirul Adlil Hakim, Mujirin, Zaid Abdullah, Hayder Al-Hraishawi, Symeon Chatzinotas, Hyundong Shin

“…Quantum computers have made significant progress in the last two decades showing great potential in tackling some of the most challenging problems in computing. …”
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Rasmussen’s Encephalitis: A Report of a Tunisian Pediatric Case and Literature Review by Hedia Klaa, Thouraya Ben Younes, Hanene Benrhouma, Sonia Nagi, Aida Rouissi, Ichraf Kraoua, Ilhem Ben Youssef-Turki

“…Rasmussen’s encephalitis (RE) is a rare progressive inflammatory disease of the central nervous system. …”
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A Severe Complication of Crack Cocaine Use by Gokul Vidyasankar, Carolina Souza, Chi Lai, Sunita Mulpuru

“…The present report describes a 48-year-old woman with a history of recurrent ‘crack’ cocaine use, who developed progressive shortness of breath over a period of years. …”
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Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas by Matilde Cacciatore, Carla Guarnotta, Marco Calvaruso, Sabina Sangaletti, Ada Maria Florena, Vito Franco, Mario Paolo Colombo, Claudio Tripodo

“…In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. …”
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Detrusor Arreflexia as an End Stage of Neurogenic Bladder in HAM/TSP? by Matheus Tannus, Davi Tanajura, Michael A. Sundberg, Paulo Oliveira, Neviton Castro, André Muniz Santos

“…Further cohort or case-series studies, with particular emphasis on the progression of neurogenic bladder, are needed to evaluate the significance of this described case in relation to typical disease progression patterns.…”
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Fuzzy decision support system for english language teaching with corpus data by Meilin Huang

“…Hence, this article introduces a Progression-focused Teaching System (PTS) optimized by Fuzzy Decision (FD). …”
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Application of immunohistochemical markers in mycosis fungoides by SHAO Kaixin, LIU Xiangjun, TANG Zhenzhen

“…Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. …”
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Magnetic Resonance Spectroscopy (MRS) transforming multiple sclerosis (MS) diagnosis by Landoline Bonnin, Pascal Bourdon, Carole Guillevin, Remy Guillevin, Clement Giraud, Christine Fernandez-Maloigne

“…Anna is one of the 1.8 million people worldwide with multiple sclerosis who live with the uncertainty of disease progression every day [1]. Traditional Magnetic Resonance Imaging scans every six months reveal brain lesions but can't predict how the disease will progress [2]. …”
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Cyclic and Explosive Evaluation of New Proposed Steel Joint by Iman Faridmehr, Yusof Ahmad, Mahmood Md. Tahir, Mohd Hanim Osman

“…The behaviour of a novel steel beam-to-column connection, the saddlebag, subjected to cyclic and progressive collapse, was evaluated in this paper. The cyclic behaviour considered the interstory drift angle and flexural strength in accordance with 2010 AISC Seismic Provisions, while progressive collapse assessment was evaluated through the plastic hinge rotation angle based on acceptance criteria provided in the UFC 4-023-03 guideline. …”
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Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. The distinct tau oligomeric polymorphs may thus contribute to the development of clinical phenotypes and shape the progression of diseases. …”
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Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches by Yifan Lu, Yifan Lu, Tiao Li, Yang Shu, Yang Shu, Chengyin Lu, Chengyin Lu, Zhiqiang Luo, Zhiqiang Luo, Jingrui Wang, Jingrui Wang, Hui Xiong, Wangyang Li, Wangyang Li

“…Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. …”
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The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

“…Conserved histone methyltransferases of the DOT1 family are involved in replication regulation, cell cycle progression, stage differentiation, and gene regulation in trypanosomatids. …”
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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease by Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek

“…Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications. …”
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