Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease by Chao-Chao Yu, Tao Jiang, Ao-Fei Yang, Yan-Jun Du, Miao Wu, Li-Hong Kong

“…Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation.…”
Get full text

Long-Term Clinical Course of Normal-Tension Glaucoma: 20 Years of Experience by Sang Wook Jin, Seung Yoon Noh

“…To identify risk factors for NTG progression, linear logistic regression analysis was employed. …”
Get full text

C-reactive Protein to Albumin Ratio as a Predictor of Infectious Etiology in Patients Admitted to General Medicine: A Single-center Prospective Observational Study by Arup Kumar Sarma, Ashabari Das, Bandana Thakuria, Priyam Saikia

“…Hence, we aimed to evaluate CAR ratio as a predictor of likelihood of progression to sepsis and to compare the ability of CAR and neutrophil to lymphocyte ratio (NLR) for the prediction of likelihood to progression of sepsis. …”
Get full text

Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning by Yiqin Yang, Mei Dong

“…Results We show that the up-regulation of oxidative stress-related genes such as IDH1 and CD36 in resident-like macrophages and foam macrophages play a key role in the formation and progression of carotid atherosclerotic plaques. Conclusions We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. …”
Get full text

Prosthetic Aortic Valve Stenosis in End-Stage Renal Failure by Michael Mao, Mirelle El Ters, Sunil Mankad, Mira Keddis, Soon Park, Qi Qian

“…Although renal failure is one of the known comorbidities associated with rapid progression of aortic stenosis, it is unclear whether hemodialysis alters the progression of prosthetic aortic valve stenosis. …”
Get full text

The institutionalisation of populist political discourse and conservative uncivil society in the European Union by Ruzza Carlo

“…I argue that the long-established EU ethos of fostering progressive civil society is undergoing a redefinition, which impacts their strategies. …”
Get full text

Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…At present, it is not clear what causes this progression, and there are no current therapies that have been successful in preventing PD progression. …”
Get full text

Potent Oral Hypoglycemic Agents for Microvascular Complication: Sodium-Glucose Cotransporter 2 Inhibitors for Diabetic Retinopathy by Eun Hyung Cho, Se-Jun Park, Seongwook Han, Ji Hun Song, Kihwang Lee, Yoo-Ri Chung

“…The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. …”
Get full text

From Recurrent Syncope to Sudden Cardiac Death: Clinical Characteristics in a Chinese Patient Carrying a Plakophilin-2 Gene Mutation by Wenling Liu, Xiaoliang Qiu, Wen Liu, Dayi Hu, Tiangang Zhu, Chunling Wang, Dominik Beer, Li Zhang

“…Electrocardiograms and cardiac imaging show the progress of ARVC and these clinical milestones of disease are presented herein.…”
Get full text

Are Pitch-Class Profiles Really “Key for Key”? by Ian Quinn

“…Our alternative approach is based on two ideas: first, that chord progressions, understood rather loosely as pairs of neighboring harmonic states demarcated by note onsets, are sufficient as windows for key-finding, at least in the chorale context; and second, that the encapsulated identity of a chord progression (modulo pitch-class transposition and revoicing) is sufficient – that is, that reduction of progressions to pitch-class distributions is not necessary for key-finding. …”
Get full text

Finerenone in the management of diabetes kidney disease by Parijat De, May T Khine, Andrew Frankel, Gabrielle Goldet, Debasish Banerjee, Rosa M Montero, Tahseen A Chowdhury, Damien Fogarty, Janaka Karalliedde, Ritwika Mallik, Dipesh C Patel, Mona Wahba, Peter Winocour, Sagen Zac-Varghese, Stephen Bain, Adnan Sharif, Srikanth Bellary, Indranil Dasgupta

“…Abstract People with type 2 diabetes are at risk of developing progressive diabetic kidney disease (DKD) and end stage kidney failure. …”
Get full text

The Biomechanics of Cervical Spondylosis by Lisa A. Ferrara

“…The altered posture of the cervical spine will progress into kyphosis and continue if the load balance and lordosis is not restored. …”
Get full text

Analysis of HPV genotype differences in different stages of cervical intraepithelial neoplasia by YU Jingmin, CHEN Yan, YANG Xuewen

“…The patients were divided into three groups based on the progression of CIN: CIN Ⅰ (n=30), CIN Ⅱ (n=42), and CIN Ⅲ (n=41). …”
Get full text

The Evolution of Rehabilitation and Return to Sport Following Cartilage Surgery by Snehal Patel, William Marrone

“…This clinical viewpoint discusses the evolution of knee cartilage rehabilitation characterized by early but progressive weightbearing and early ROM while maintaining early homeostasis in the knee, and then its progression to return to sport and performance in the higher-level athlete…”
Get full text

Kinetic pH Titration to Predict the Acid and Hydrothermal Conditions for the Hydrolysis of Disaccharides: Use of a Microcapillary System by Toshinori Shimanouchi, Ryota Mano, Yu Yoshioka, Ayaka Fukuda, Kyung-Min Park, Yukitaka Kimura

“…The hydrolysis reaction showed a sigmoidal progression with time, especially under alkaline conditions. …”
Get full text

Treating Penile Cancer in the Immunotherapy and Targeted Therapy Era by Gavin Hui, Sanaz N. Ghafouri, John Shen, Sandy Liu, Alexandra Drakaki

“…We report a case series of two patients who improved on immunotherapy after progressing with standard chemotherapy regimens. The first case describes a 64-year-old male with a penile mass and significant lymphadenopathy who had surgical resection and adjuvant chemotherapy prior to continued disease progression. …”
Get full text

Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin by M. Tesauro, A. Mascali, O. Franzese, S. Cipriani, C. Cardillo, N. Di Daniele

“…Several elements contribute to determine a progression of the kidney injury, inducing a worsening of renal damage and accelerating the decline of renal function: obesity and hypertension are two known factors of kidney progression. …”
Get full text

A 15-Item modification of the PSP rating scale to improve clinical meaningfulness and statistical performance by Tien Dam, Lili Yang, Colin Gillis, Yumeng Li, John O’Gorman, Barbara Kolb, Adam L. Boxer, Lawrence Golbe, Samantha Budd Haeberlein, On behalf of the AL-108-231, PROSPERA, and 4RTNI investigators

“…Abstract Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder characterized by physical, cognitive, and behavioral impairments. …”
Get full text

Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation–Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE) by Chee Khoon Lee, PhD, Bin-Chi Liao, MD, Shalini Subramaniam, MMed (Clin Epi), Chao-Hua Chiu, MD, Antony J. Mersiades, MMed (Clin Epi), Chao-Chi Ho, MD, PhD, Chris Brown, MBiostats, Chun-Liang Lai, MD, PhD, Brett G.M. Hughes, M.B.B.S. (Hons), Tsung-Ying Yang, MD, PhD, Ken O’Byrne, MD, Yung-Hung Luo, MD, PhD, Sonia Yip, PhD, Ching-Liang Ho, MD, Victoria Bray, PhD, Wu-Chou Su, MD, PhD, Melissa Moore, PhD, Wei-Lien Feng, MS, Ya-Ying Bai, MS, Kate Ford, MHSc, Michelle M. Cummins, PhD, Martin R. Stockler, MSc (Clin Epi), Benjamin J. Solomon, PhD, Thomas John, PhD, James Chih-Hsin Yang, MD, PhD

“…Participants were divided into two cohorts: (1) EGFR exon 20 T790M negative (T790M−, progressing on either first-line osimertinib, or on a single line of first/second generation TKI), and (2) T790M positive (T790M+, progressing on greater than or equal to 1 lines of TKI, including osimertinib). …”
Get full text

Regulation of T Helper 17 by Bacteria: An Approach for the Treatment of Hepatocellular Carcinoma by Cecilia Ying Ju Sung, Nikki Pui-yue Lee, Hani El-Nezami

“…Its presence seems to be linked with HCC progression, possibly via facilitating angiogenesis. …”
Get full text