Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

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Design of adhesively-bonded single lap joints for automotive applications under compressive loading by Ferhat Kadioglu, Murat Demiral

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Investigation of 3D steel frames with a reduced beam section and various web-opening shapes under internal column loss by Ali Altheeb, Ibrahim M. H. Alshaikh, Aref A. Abadel, Moncef L. Nehdi, B.H. Abu Bakar

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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling by Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu, Jilei Li, Kedeerya Aishanjiang, Yujie Ma, Chang Yu, Bo Yu, Chunhong Cui, Hui Wang, Xianming Kong, Shibo Li, Xiaoni Kong, Ying Tong, Hailong Wu

“…Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated. …”
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Research progress of Traditional Chinese Medicine characteristic nursing techniques for patients with pancreatic cancer (中医特色护理技术在胰腺癌中的应用研究进展) by GAO Donghua (高冬华), WANG Guiting (王贵婷), ZHANG Xinhui (张鑫辉), TIAN Wanqin (田婉琴), Tang Ling (唐玲)

“…Its clinical manifestations are mainly abdominal discomfort and dull pain, often accompanied by loss of appetite, loss of body shape and obstructive jaundice. With the progress of the disease, the quality of life, work and survival of patients are seriously affected. …”
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Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

“…We found that peritoneal Mp appeared as an “incomplete” OMp phenotype with decreased icGSH along with disease progression. The OMp showed reduced TNF-α, IL-12, and NO production as well as defective phagocytosis activity compared to nondiabetic controls; however, there was no significant difference with IL-6 production. …”
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PReventing Idiopathic SCOliosis PROgression (PRISCOPRO): A protocol for a quadruple-blinded, randomized controlled trial comparing 3D designed Boston brace to standard Boston brace. by Elias Diarbakerli, Anastasios Charalampidis, Allan Abbott, Paul Gerdhem

“…Treatment strategies aim to halt progression of the curve. Patients are treated mainly with thoracolumbosacral orthosis (TLSO) if indicated. …”
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MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…Emerging evidence indicates that long non-coding RNAs (lncRNAs) are crucial in the carcinogenesis and progression of various cancers, regulating multiple biological processes but the link between KRASG12D mutations and lncRNAs in CRC remains unclear. …”
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Research progress on the intervention of mobile health Apps in the health management of cancer patients (移动健康APP在癌症患者健康管理干预中的研究进展) by WANG Tian (王田), LI Juan (李娟), MEI Yafan (梅亚凡)

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Progress in voluntary medical male circumcision for HIV prevention supported by the US President’s Emergency Plan for AIDS Relief through 2017: longitudinal and recent cross-sectional programme data by Carlos Toledo, Melissa Habel, Stephanie M Davis, Jonas Z Hines, Jonathan M Grund, Renee Ridzon, Brittney Baack, Jonathan Davitte, Anne Thomas, Valerian Kiggundu, Naomi Bock, Paran Pordell, Caroline Cooney, Irum Zaidi

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Research progress in nursing of multiple myeloma complicated by peripheral neuropathy (多发性骨髓瘤并发周围神经病变患者的护理研究进展) by LI Lixia (李丽霞), BAN Jinchun (班锦青), LIANG Jinglin (梁静林), NONG Zhenzhen (农珍诊), WEI Ling (韦玲)

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Research progress of Traditional Chinese medicine nursing techniques for constipation in stroke patients (中医护理适宜技术在卒中后便秘患者中的应用进展) by WANG Fang (王芳), GENG Qingwen (耿庆文)

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Aging-enhanced autophagy activity promotes fibrotic progression via the TGF-β2/Smad signaling pathway in trabecular meshwork cells—a new insight from POAG by Jin Han, Jun Wang, Ling Shen, Yiting Cai, Xuze Wang, Ailixiati Wumaier, Wei Chen, Wei Han

“…Further investigation showed that enhanced autophagy activity promoted fibrotic progression via activation of the TGF-β2/Smad signaling pathway. …”
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The association between acute myocardial infarction and constipation and progress in nursing care studies (急性心肌梗死与便秘的相关性及护理研究进展) by FAN Yufei (范羽飞), YANG Yang (杨阳), ZANG Yaning (臧亚宁), ZHANG Dan (张丹)

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Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Cancer Treated with Carboplatin plus Etoposide by Hisao Imai, Keita Mori, Nodoka Watase, Sakae Fujimoto, Kyoichi Kaira, Masanobu Yamada, Koichi Minato

“…Type of relapse (refractory/sensitive) and the number of regimens administered after disease progression after the first-line chemotherapy were both significantly associated with PPS (p<0.05). …”
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替奈普酶治疗急性缺血性卒中的研究进展及展望 Research Progress and Prospect of Tenecteplase in the Treatment of Acute Ischemic Stroke by 徐露，董漪，董强 (XU Lu, DONG Yi, DONG Qiang)

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Research progress of clinical intervention for apnea in extremely and very preterm infants (极早和超早产儿呼吸暂停临床干预方法进展) by LU Lijun (陆丽君), FENG Xuemo (冯雪茉), LU Yunhong (卢运红)

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Research progress of continuous care of patients after percutaneous coronary intervention (经皮冠状动脉介入治疗术后患者延续性护理的研究进展) by JIA Hongwei (贾红薇), LIU Ning (刘宁), QI Yanchun (齐艳春), (韩平平), LI Rongyan (李荣艳), WANG Lijun (王丽君), SHAN Xiaoyan (单晓燕), YANG Lin (杨林)

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Comparative analysis of 2 approaches to monitor countries' progress towards full and equal access to sexual and reproductive health care, information, and education in 75 countries: An observational validation study. by Jewel Gausman, Richard Adanu, Delia A B Bandoh, Neena R Kapoor, Ernest Kenu, Ana Langer, Magdalene A Odikro, Thomas Pullum, R Rima Jolivet

“…This indicator plays a key role in tracking global progress toward achieving gender equity and empowerment, ensuring its validity is essential. …”
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Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review by Yuka Ogawa, Dai Kishida, Yasuhiro Shimojima, Koichi Hayashi, Yoshiki Sekijima

“…We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab). …”
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