RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli by Charlotte Roux, Marvin Ramos-Hue, Marjorie Audonnet, Marie-Pierre Duviau, Sébastien Nouaille, Agamemnon J. Carpousis, Sandrine Laguerre, Eliane Hajnsdorf, Muriel Cocaign-Bousquet, Laurence Girbal

“…These results clearly demonstrate that PAP I mediates an energy-dependent RNA stabilization, which may contribute to cell energy homeostasis under energy-limited conditions.IMPORTANCEPoly(A) polymerases are prime targets for understanding the interactions between RNA polyadenylation, RNA stability, and cellular energy. …”
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Safety profile of sacituzumab govitecan in patients with breast cancer: A systematic review and meta-analysis by Maria Inez Dacoregio, Isabella Michelon, Caio Ernesto do Rego Castro, Francisco Cezar Aquino de Moraes, Guilherme Rossato de Almeida, Lis Victória Ravani, Maysa Vilbert, Ricardo Lima Barros Costa

“…Background: Sacituzumab Govitecan (SG), a first-in-class anti-trophoblast cell surface antigen-2-directed antibody-drug conjugate (ADC), has shown clinically meaningful improvement in outcomes of patients with breast cancer (BC). …”
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Antibacterial Potential of Honeybee Venom and <i>Monascus purpureus</i> Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria by Islam I. Teiba, Yasser S. A. Mazrou, Abeer H. Makhlouf, Yasser Nehela, Abdallah E. Mohamed, Ahmed M. Abbas, Islam Mamdouh, Emad H. El-Bilawy

“…Scanning electron microscopy (SEM) revealed that BV and RD extracts disrupted the bacterial plasma membrane, suggesting that the bioactive compounds penetrate the bacterial cell wall and alter its integrity. Furthermore, GC–MS-based analysis revealed that the chemical composition of BV and RD extracts exhibited highly diverse structures, including complex polycyclic systems, porphyrins, steroids, and esters. …”
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Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats by Li WU, Yuan ZHANG, Chunhong TANG, Huan YOU, Haijun CHANG, Shuai ZHANG

“…The phenomenon of inflammatory cell infiltration in hepatocytes improved, homogeneous thickening of glomerular basement membranes and the increase in the stroma of glomerular tethered membranes were ameliorated, and the morphology of islets showed improvement with reduced autolysis phenomenon. …”
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Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

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Implementasi Data Mining untuk Deteksi Penyakit Ginjal Kronis (PGK) menggunakan K-Nearest Neighbor (KNN) dengan Backward Elimination by Ikhsan Wisnuadji Gamadarenda, Indra Waspada

“…System recommendations produce 10 attributes selected from the 24 initial attributes used, namely: specific gravity (sg), albumin (al), blood urea (bu), serum creatinine (sc), sodium (soil), hemoglobin (hemo), cell red blood (rbc), hypertension (htn), diabetes mellitus (dm), and appetite (appetite). …”
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Evaluation of Six Novel Protein Sources on Apparent Digestibility in Pacific White Shrimp, Litopenaeus vannamei by Xiaoyue Li, Yongkang Chen, Chaozhong Zheng, Shuyan Chi, Shuang Zhang, Beiping Tan, Shiwei Xie

“…To conclude, newly developed protein sources such as single-cell protein (CAP, BPM, and CM) showed great potential as a fishmeal alternative, and insect protein meals (TM and BSFLM) were less effective for shrimp compared to the CD. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Abstract Background Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxic stress such as tau accumulation, a characteristic feature of Alzheimer's disease (AD) and other tauopathies. …”
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Hubungan Aktivitas Fisik dengan Kadar Nitric Oxide (NO) Plasma pada Masyarakat di Kota Padang by Ghozi Natul Isral, Afriwardi ., Delmi Sulastri

“…<br />Kata kunci: Aktivitas fisik, NO</p><p>Abstract<br />Nitric oxide is relaxan factor that is synthesized by endothelial cell of blood vessel. From previous research showed that plasma NO level influenced by physical activity. …”
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Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study... by Akshatha Shetty, Shama Prasada K, Diya Rajasekhar Chinta, Ganesh Shenoy, Amruth Kiran, Vasudha Devi, Arul Amuthan, Smita Shenoy, Manjunath Shetty, Mohandas Rao K G, Nitesh Kumar

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Perfluorooctanoic acid induces abnormal heart development via aryl hydrocarbon receptor-mediated oxidative stress and apoptosis in zebrafish larvae by Xueyi CHEN, Tianchi MA, Kang WANG, Tao CHEN, Yan JIANG

“…The aryl hydrocarbon receptor (AHR) is a critical environmental sensor capable of inducing oxidative stress and cell apoptosis. ObjectiveTo explore the role of AHR in the cardiac developmental toxicity of PFOA by using zebrafish embryo as an in vivo model. …”
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Bases cérébrales de la motivation chez le singe rhésus : études pharmacologiques et neurophysiologiques by Chiara Varazzani, Aurore San‑Galli, Caroline Jahn, Nicolas Borderies, Sébastien Bouret

“…Une fois les singes entrainés, nous mesurons l’activité des neurones du cortex préfrontal, ainsi que celle des neurones à dopamine (DA) de la substance noire (SN) et des neurones à noradrénaline (NA) du locus coeruleus (LC). …”
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Effect of Exercise Preconditioning on Protein Expression of VEGF and NeuN in Rats with Cerebral Ischemia-reperfusion by Fei PEI, Xuedong WANG, Baolong LI, Qiang TANG, Luwen ZHU

“…Compared with the model group, the neurological deficit scores of the exercise model group at 24 hours and 3 days after cerebral ischemia-reperfusion decreased, and the comparison between the two groups was statistically significant (<italic>P</italic>&lt; 0.05). 2) 24 hours after cerebral ischemia-reperfusion, a small amount of VEGF expression were seen in the sham operation group, the positive cell bodies were small, and the protrusions were thin; compared with the positive rate of the exercise model group (14.40%), the positive rate of the sham-operation group (4.70%), the positive rate of the model group (9.80%), the positive rate of the exercise sham-operation group (8.80%) were low, and the differences were statistically significant respectively (<italic>P</italic>&lt; 0.05). …”
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Assessing Heat Resistance and Selecting Heat-Resistant Individuals of Largemouth Bass (<i>Micropterus salmoides</i>) with Tiered Thermal Exposure by Haijie Chen, Hui Qiao, Zhicheng Xv, Guili Song, Shuning Liu, Cheng Luo, Yong Long, Shimei Lin

“…The liver tissues of the heat-sensitive individuals showed significant damage and increased cell apoptosis (<i>p</i> < 0.05) relative to those of the resistant ones. …”
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Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…Comparison of the other genetic characteristics including immune cell infiltration score, tumor mutation burden (TMB), and microsatellite instability (MSI). …”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…Chemotherapy-free option lenvatinib plus anti-programmed cell death protein-1 (PD-1) combination therapy has shown promising results in several malignancies including ovarian cancer, but the toxicity of a high starting dose of lenvatinib is also notable and needs to be improved. …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…The CIBERSORT algorithm assessed the correlation between MAP17 and immune cell infiltration within the tumor microenvironment (TME), while the TIDE algorithm predicted responses to immunotherapy. …”
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Linear association between high-sensitivity C-reactive protein and postoperative delirium after general anesthesia: a cross-sectional study by Xiao Qin, Junming Ren, Chunping Xing, Lijiao Chen, Renjie Wang, Shouyuan Tian

“…Compared to the lower Hs-CRP group, patients in the higher Hs-CRP group exhibited higher age, heart rate, white blood cell count, blood urea nitrogen, creatinine, uric acid, fasting glucose, hemoglobin A1c, fibrinogen, D-dimer, and a higher prevalence of CKD, but lower hemoglobin, high-density lipoprotein cholesterol, albumin and estimated glomerular filtration rate. …”
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Linearly Polarized <i>γ</i> Photon Generation from Unpolarized Electron Bunch Interacting with Laser by Yang He, Burabigul Yakup, Mamat Ali Bake

“…We investigate the scheme by considering the electron bunch of various initial energies and various laser intensities using two-dimensional particle-in-cell simulation and the theory of quantum electrodynamics. …”
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Physicochemical characterization of biodegradable polymer polyhydroxybutyrate from halophilic bacterium local strain Halomonas elongata by W.O.S. Rizki, E. Ratnaningsih, D.G.T. Andini, S. Komariah, A.T. Simbara, R. Hertadi

“…The maximum polyhydroxybutyrate production in this medium reached 2.93 ± 0.03 gram per liter dry cell weight and 78 ± 1 percent polyhydroxybutyrate concentration. …”
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