Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends by Hong-Yu Jiang, Hong-Yu Jiang, Bo Shao, Bo Shao, Hong-Da Wang, Hong-Da Wang, Wen-Qi Zhao, Shao-Hua Ren, Shao-Hua Ren, Shao-Hua Ren, Yi-Ni Xu, Yi-Ni Xu, Tong Liu, Tong Liu, Cheng-Lu Sun, Cheng-Lu Sun, Yi-Yi Xiao, Yi-Yi Xiao, Yi-Cheng Li, Yi-Cheng Li, Qiang Chen, Qiang Chen, Peng-Yu Zhao, Peng-Yu Zhao, Guang-Mei Yang, Guang-Mei Yang, Xu Liu, Xu Liu, Yu-Fan Ren, Yu-Fan Ren, Hao Wang, Hao Wang, Hao Wang

“…Keyword analysis revealed that current research hotspots include drug delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, and nanovesicles.ConclusionThis study offers a comprehensive overview of global research landscape, emphasizing the rapid growth and increasing complexity of this field. …”
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Interfacial friction enabling ≤ 20 μm thin free-standing lithium strips for lithium metal batteries by Shaozhen Huang, Zhibin Wu, Bernt Johannessen, Kecheng Long, Piao Qing, Pan He, Xiaobo Ji, Weifeng Wei, Yuejiao Chen, Libao Chen

“…Meanwhile, the LiFePO4 (with single-sided load 10 mg/cm2) ||Li@ZDDP full cell can last over 350 cycles with a high-capacity retention of 82% after the formation cycles at 5 C (1 C = 170 mA/g) and 25 °C. …”
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Characterization and enhanced antibiofilm activity of Annona muricata extract in combination with fluconazole against Candida albicans by Abhay Mishra, Masande Yalo, Jennifer Nambooze, Carolina H. Pohl, Gabré Kemp, Lekgoana K. Setsiba, Motlalepula G. Matsabisa

“…SEM analysis revealed altered biofilm morphology and loss of cell integrity with the combination treatment. Phytochemicals showed high binding affinity (−9.7 to −8.0 kcal/mol) for the Sap3 enzyme, suggesting therapeutic potential. …”
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Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources by Magdalena Mititelu, Dumitru Lupuliasa, Sorinel Marius Neacșu, Gabriel Olteanu, Ștefan Sebastian Busnatu, Andreea Mihai, Violeta Popovici, Nicoleta Măru, Steluța Constanța Boroghină, Sebastian Mihai, Corina-Bianca Ioniță-Mîndrican, Alexandru Scafa-Udriște

“…Beyond the fact that they provide a substantial supply of energy to the body (a role that saturated fats can also perform), these unsaturated fatty acids and, especially, the essential ones are involved in cell membrane structure, blood pressure regulation, and coagulation; participate in the proper functioning of the immune system and assimilation of fat-soluble vitamins; influence the synthesis of pro- and anti-inflammatory substances; and protect the cardiovascular system. …”
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Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis by Andrea Costamagna, Eleonora Balzani, Matteo Marro, Erika Simonato, Alessandro Burello, Mauro Rinaldi, Luca Brazzi, Massimo Boffini, Vito Fanelli

“…PGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the association between the levels of proinflammatory biomarkers during EVLP and PGD3 development within the firsts 72 h post-Ltx. …”
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Fragment optimized chalcone derivatives targeting OmpA protein as a therapeutic approach against multidrug resistant Acinetobacter baumannii by Muhammad Naveed, Amina Abid, Tariq Aziz, Ayesha Saleem, Arooj Arshad, Khushbakht Javed, Hafiz Muzzammel Rehman, Ghulam Nabi, Mitub Al-harbi, Abdullah F. Alasmari

“…Abstract Acinetobacter baumannii is a notorious pathogen associated with life-threatening infections, with its outer membrane protein A (OmpA) being a key contributor to its pathogenicity by targeting epithelial cell apoptosis. The study presents an in silico analysis of chalcone derivatives as potential therapeutic agents against the outer membrane protein A (OmpA) of Acinetobacter baumannii. …”
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CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy by Samya Jezine Da Silva, Mauro Jorge Cabral-Castro, Luiz Claudio Faria, Carolina Rosadas, Maria Fernanda Lopes de Araújo, Ana Caroline Soares Dutra, Yoshihisa Yamano, Graham Taylor, Marzia Puccioni-Sohler

“…Results: Higher white cell counts and concentrations of protein, neopterin, and CXCL-10 in CSF were detected in group A (patients with HAM) and group B (<i>p</i> < 0.05). …”
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Characterization of the genomic landscape in liver oligometastatic NSCLC by Rongxin Liao, Guangming Yi, Lu Shen, Xiao Xiao, Chuan Zeng, Liangzhong Liu, Hongjun Tang, Shunping Huang, Xiaoyue Zhang, Zaicheng Xu, Zhenzhou Yang, Yuan Peng

“…Abstract Objectives Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. …”
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Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model by Radka Pecková, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Ivan Petřík, Wisnu Nurcahyo, Ivona Foitová

“…The cytotoxicity of the extracts was determined by the MTT Cell Viability Assay. Results We recorded a statistically-significant decrease in giardia trophozoites in two extracts: the methanolic extract of A. fagifolium (Kruskal-Wallis: p = 0.013) and the aqueous extract of P. betle (Kruskal-Wallis: p = 0.002). …”
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Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks by Jianhong Chen, Qun Fang, Baojiang Chen, Yi Zhou, Yanmin Luo

“…The relationship between chromosomal abnormal karyotype and IGF-II gene imprinting status was analyzed by primary cell culture and G-banding chromosomal karyotype analysis. …”
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Machine learning-based identification of proteomic markers in colorectal cancer using UK Biobank data by Swarnima Kollampallath Radhakrishnan, Dipanwita Nath, Dominic Russ, Dominic Russ, Dominic Russ, Laura Bravo Merodio, Laura Bravo Merodio, Laura Bravo Merodio, Priyani Lad, Folakemi Kola Daisi, Animesh Acharjee, Animesh Acharjee, Animesh Acharjee

“…Using SHapley Additive exPlanations values, TFF3, LCN2, and CEACAM5 were found to be key biomarkers associated with cell adhesion and inflammation. Protein quantitative trait loci analyze studies provided further evidence for the involvement of TFF1, CEACAM5, and SELE in colorectal cancer, with possible connections to the PI3K/Akt and MAPK signaling pathways. …”
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Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model by Emma Steijvers, Yunshong Shi, Hong Lu, Weixin Zhang, Yitian Zhang, Feihu Zhao, Baichuan Wang, Louise Hughes, Jake E. Barralet, Giulia Degli-Alessandrini, Igor Kraev, Richard Johnston, Zengwu Shao, Frank H. Ebetino, James T. Triffitt, R. Graham G. Russell, Davide Deganello, Xu Cao, Zhidao Xia

“…To understand the biodegradation and the cellular activity at the cell/biomaterial interfaces, non-decalcified specimens were resin embedded and sections subjected to combined scanning electron microscopy (SEM)/electron backscatter diffraction (EBSD)/energy dispersive X-ray spectrometry (EDS) analysis. …”
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First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population by Tran Quang Binh, Pham Tran Phuong, Nguyen Thanh Chung, Bui Thi Nhung, Do Dinh Tung, Tran Quang Thuyen, Duong Tuan Linh, Bui Thi Thuy Nga, Nguyen Anh Ngoc, Le Danh Tuyen

“…Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. …”
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Anti-caries effect of a novel elastic silicone appliance material incorporating sodium fluoride by Shuxing Yu, Lingyu Zhang, Qizhao Ma, Jing Zhou, Yaqi Liu, Jing Zou, Qiong Zhang

“…The hardness of demineralized and remineralized bovine enamel was measured.ResultsIncorporating NaF (0.5, 1, and 1.5%) resulted in no cytotoxic effects, with cell viability &gt;85%. The fluoride release rate initially increased over 14 days, followed by a gradual decline, maintaining a steady release for approximately 28 days. …”
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Nephrotic Syndrome and Idiopathic Membranous Nephropathy Associated with Autosomal-Dominant Polycystic Kidney Disease by Ramón Peces, Jorge Martínez-Ara, Carlos Peces, Mariluz Picazo, Emilio Cuesta-López, Cristina Vega, Sebastián Azorín, Rafael Selgas

“…Findings in this patient also suggest that MFM might reduce cystic cell proliferation and fibrosis, preventing progressive renal scarring with preservation of renal function.…”
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Modern advancements of energy storage systems integrated with hybrid renewable energy sources for water pumping application by Marwa M. Ahmed, Haneen M. Bawayan, Mohamed A. Enany, Mahmoud M. Elymany, Ahmed A. Shaier

“…Basic areas discussed include photovoltaic water pumping systems (PVWPS), with a focus on solar cell technologies, DC-DC converters, motor-pump configurations, and maximum power point tracking (MPPT) techniques; wind energy water pumping systems (WEWPS), analyzing wind turbine designs, motor-pump compatibility, and hybrid configurations; and energy storage systems (ESSs), covering battery technologies, water tanks, and hybrid storage solutions to enhance reliability and mitigate renewable energy intermittency. …”
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Overexpression of StBBX14 Enhances Cold Tolerance in Potato by Heng Zhang, Mingjun Chen, Xiaobo Luo, Li Song, Fei Li

“…A Gene Ontology enrichment analysis revealed that photosynthesis, cell wall, thylakoid, transcription regulator activity, oxidoreductase activity and glucosyltransferase activity were significantly enriched in <i>OE-StBBX14</i> and WT. …”
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Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline by Ge Gao, Ge Gao, Caipeng Lin, Caipeng Lin, Ruibo Li, Xi Xie, Hai-Bin Luo, Hai-Bin Luo

“…Optimal ARE concentrations were established using the Cell Counting Kit-8. The impact of ARE on extracellular matrix (ECM)-related protein expression was assessed through RT-qPCR and Western blot techniques. …”
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Glutathione-dependent system in the blood of gastric cancer patients with various tumor histotypes and prevalence of the disease by I. A. Goroshinskaya, E. I. Surikova, E. M. Frantsiyants, L. A. Nemashkalova, P. S. Kachesova, D. E. Medvedeva, A. A. Maslov

“…The maximum increase was observed in patients with low-grade adenocarcinoma - by 42.5 %, while in signet ring cell carcinoma (SRCC) there was only a tendency to increase by 17.8 %. …”
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Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis? by Marie-Lise Gougeon, Valérie Seffer, Cezarela Hoxha, Elisabeth Maillart, Michel R. Popoff

“…Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system. Many possible causes of MS have been proposed, including genetic factors, environmental triggers, and infectious agents. …”
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