Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease by Jared M. Fine, Jacob Kosyakovsky, Tate T. Bowe, Katherine A. Faltesek, Benjamin M. Stroebel, Juan E. Abrahante, Michael R. Kelly, Elizabeth A. Thompson, Claire M. Westby, Kiley M. Robertson, William H. Frey, Leah R. Hanson

“…Using RNA-sequencing and pathway analysis, STZ was shown to induce several pathways of cell death and neuroinflammation, and IN DFO engaged multiple transcriptomic pathways involved in hippocampal neuronal survival.DiscussionTo our knowledge this study is the first to assess the transcriptomic pathways and mechanisms associated with either the ICV STZ model or DFO treatment, and the first to demonstrate efficacy at this low dose.…”
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Additives in foods marketed to children in Uruguay, an emerging Latin American country by Florencia Alcaire, Ana Giménez, Gastón Ares

“…All packaged products available in each supermarket were surveyed using a cell phone app, except for culinary ingredients. …”
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Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer via Regulating PI3K/AKT/NFκB Pathway and Tumor‐Associated Macrophage by Xiaojiao Sun, Junling Zhang, Bingqi Dong, Qingqing Xiong, Xin Wang, Yanlun Gu, Zhiqi Wang, Huiyu Liu, Jixin Zhang, Xu He, Hongjin Liu, Yi Zhong, Chuxiao Yi, Xiaowei Chi, Zhenming Liu, Xiaocong Pang, Yimin Cui

“…Furthermore, the results from coculture models and single‐cell RNA sequencing analyses suggested SLITRK4 promoted tumor‐associated macrophages (TAMs) infiltration and polarization. …”
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Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation by Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao

“…In vivo, this valve scaffold promises to mitigate early inflammatory damage and provide a pro‐endothelialization niche for scaffolds' constructive remodeling. With the use of cell coculture systems and transcriptome sequencing, the mechanism of immune‐modulating scaffold accelerating endothelialization is being elucidated. …”
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Bacterial diversity determination using culture-dependent and culture-independent methods by M. Ghiasian, A. Akhavan Sepahy, M.A. Amoozegar, S. Saadatmand, M. Shavandi

“…Prokaryotes diversity in Mud volcano has been studied by cultivation techniques, fluorescence in situ hybridization, and denaturing gradient gel electrophoresis of PCR-amplified fragments of 16S rRNA genes. Total cell abundance in the mud volcano from 1×101-6×101per milliliter was determined by 4', 6-diamidino-2-phenylindole direct count. …”
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Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration by Huihui Du, Dongdong Zhang, Kui Xue, Limin Ma, Ru Xu, Ji Tan, Feng Peng, Xuanyong Liu

“…The results indicated that Cur-Fe nanoflower coating can promote protein adsorption, cell adhesion and proliferation, exhibiting excellent biocompatibility. …”
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On‐chip label‐free impedance‐based detection of antibiotic permeation by Jaspreet Kaur, Hamed Ghorbanpoor, Yasin Öztürk, Özge Kaygusuz, Hüseyin Avcı, Cihan Darcan, Levent Trabzon, Fatma D. Güzel

“…In particular, with the rise in antibiotic resistance amongst pathogenic bacteria, the study of antibiotic activity and transport across cell membranes in the field of biosensors has been gaining widespread importance. …”
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Scale effects of physically based TOPKAPI model in reservoir inflow flood forecasting for ungauged basins by Yihua Sheng, Zhijia Li, Zhiyu Liu, Yalei Han, Jie Wang, Junfu Gong, Ning Xu

“…New hydrological insights: The results reveal a strong correlation between geomorphological features and scale, with variations in grid cell size affecting the statistical characteristics of underlying surface data. …”
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Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study by Chia-Hung Chen, Wen-Chien Cheng, Biing-Ru Wu, Chih-Yu Chen, Wei-Chun Chen, Wei-Chih Liao, Chih-Yen Tu

“…A total of 92 patients (median age 64 years) were included in the study, most of whom were men (65.2%). Cytological cell block (CCB) and CPB made definitive diagnoses in 32/92 (34.8%) and 25/92 (27.5%), respectively; flexible forceps biopsy (FFB) and cryoprobe biopsy (CB) established definitive diagnoses in 84/92 (91.3%) and 91/92 (98.9%), respectively. …”
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Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer by Michelle Wilson, Naveen S Vasudev, Grant D Stewart, Adebanji Adeyoju, Jon Cartledge, Michael Kimuli, Shibendra Datta, Damian Hanbury, David Hrouda, Grenville Oades, Poulam Patel, Naeem Soomro, Mark Sullivan, Jeff Webster, Peter J Selby, Rosamonde E Banks

“…Objectives To describe the frequency and nature of symptoms in patients presenting with suspected renal cell carcinoma (RCC) and examine their reliability in achieving early diagnosis.Design Multicentre prospective observational cohort study.Setting and participants Eleven UK centres recruiting patients presenting with suspected newly diagnosed RCC. …”
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Chokeberry juice affects membrane lipid status and cellular antioxidant enzymes in healthy women with aerobic training activity by Nevena Vidović, Ana Pantović, Vuk Stevanović, Ivana Šarac, Kristina Robal, Stevan Stevanović, Maria Glibetic

“…Our study indicates that supplementation with chokeberry juice may induce favorable changes in cell fatty acid composition and antioxidant response in women performing aerobic training.…”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…Isoquinoline alkaloids from Corydalis yanhusuo, hangeshashinto, osthol, and cannabidiol inhibited Na+ currents in cell models, primarily affecting Nav1.7 and Nav1.5. …”
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Effect of opercular deformity on morphological and transcriptomic profiling of gills in golden pompano (Trachinotus ovatus) by Yuwei Wu, Qian Ma, Dihao Huang, Liuyong Wang, Qiling Zhou, Chunli Ran, Gang Chen

“…KEGG pathway enrichment analysis of the DEGs indicated notable enrichment in pathways related to immune response and inflammation, including Staphylococcus aureus infection, leukocyte transendothelial migration, tight junction, and cell adhesion molecules pathways. These enrichment analysis results suggest that functions associated with immunity and disease, ion homeostasis, energy metabolism, and apoptosis may be influenced by the opercular deformity.…”
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LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36 by Yingrong Leng, Yanqiu Zhang, Yang Cheng, Shengtao Ye, Ying Zheng, Mengmeng He, Enyi Wu, Lingyi Kong, Hao Zhang

“…Furthermore, LIX1L deficiency-mediated downregulation of CD36 reprograms the tumor-prone liver microenvironment with increased cytotoxic T lymphocytes and reduced immunosuppressive cell proportions. These data indicate a systematic function of LIX1L in the pathogenesis of MASH and underscore targeting PARP1/LIX1L/CD36 axis as a feasible strategy for treatment of MASH and associated HCC.…”
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The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes by Luuk A. de Wert, Margot Geerts, Sander van der Brug, Laura Adriaansen, Martijn Poeze, Nicolaas Schaper, Nicole D. Bouvy

“…A laser Doppler flowmeter measured cutaneous blood cell flux (CBF) as a measure of the reactive hyperaemic skin response. …”
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Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer by Solmaz AghaAmiri, Jo Simien, Alastair M. Thompson, Julie Voss, Sukhen C. Ghosh, Servando Hernandez Vargas, Sarah Kim, Ali Azhdarinia, Hop S. Tran Cao

“…In vitro binding was evaluated in HER2-overexpressing (BT474, SKBR3) and HER2-negative (MCF7) cell lines. BT474 and MCF7 xenografts were used for in vivo and ex vivo fluorescence imaging. …”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…This issue stems from the complex nature of diseases, which involve altered interactions among thousands of genes across multiple cell types and organs. Disease progression can vary between patients and over time, influenced by genetic and environmental factors. …”
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Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

“…Immunodeficiency, centromeric instability, and facial anomalies syndrome (ICF) is a rare genetic disease characterized by hypogammaglobulinemia, T cell immune deficiency with age, pericentromeric hypomethylation, facial abnormalities, and intellectual disability. …”
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Effective Resistivity in Relativistic Reconnection: A Prescription Based on Fully Kinetic Simulations by Abigail Moran, Lorenzo Sironi, Aviad Levis, Bart Ripperda, Elias R. Most, Sebastiaan Selvi

“…In this work, we analyze a suite of fully kinetic particle-in-cell (PIC) simulations of relativistic pair-plasma reconnection—where the magnetic energy is greater than the rest mass energy—for different strengths of the guide field orthogonal to the alternating component. …”
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Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights by Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

“…To assess the immunological landscape, we employed the xCell algorithm. Through logistic regression analysis, the four core HRGs (CCT2, HSPA6, DNAJB14, and DNAJC5) were confirmed as potential biomarkers for AS. …”
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