Genomic characterization of foodborne Salmonella enterica and Escherichia coli isolates from Saboba district and Bolgatanga Municipality Ghana. by Gabriel Temitope Sunmonu, Frederick Adzitey, Erkison Ewomazino Odih, Boniface Awini Tibile, Rejoice Ekli, Martin Aduah, Anderson O Oaikhena, Olabisi C Akinlabi, Akebe Luther King Abia, Daniel Gyamfi Amoako, Iruka N Okeke

“…Most Salmonella isolates were pan-sensitive, but genes conferring resistance to fosfomycin (fosA7.2) and tetracycline (tet(A)) were detected in one and three isolates, respectively. …”
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Molecular basis for azetidine-2-carboxylic acid biosynthesis by Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll

“…AZE synthases catalyse the intramolecular 4-exo-tet cyclisation of S-adenosylmethionine (SAM), yielding a highly strained heterocycle. …”
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Evaluating bacterial resistance to antimicrobials in isolated bacteria from food contact surfaces by Paola Andrea Caro-Hernández, Juan Camilo Orozco-Mera, Olga Lucia Castaño-Henao, Mauricio Alberto Quimbaya-Gómez

“…El análisis de PCR encontró que el gen tet M fue el más frecuente. Además, se evidenció que, si bien el NaOCl es efectivo como desinfectante de superficies, Aerococcus urinae y Kocuria kristinae pudieron resistir hasta 10 minutos de exposición. …”
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Antimicrobial susceptibility, virulence characteristics, and incidence of class 1 and 2 integrons in salmonella infantis isolated from clinical cases in broilers by Özkan ASLANTAŞ, Süheyla TÜRKYILMAZ

“…WGS analysis revealed the presence of different resistome, but aac(6")-Iaa and tetA genes in all isolates, and mutations in gyrA and parC genes playing a role in quinolone resistance. …”
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Tristemma hirtum and Five Other Cameroonian Edible Plants with Weak or No Antibacterial Effects Modulate the Activities of Antibiotics against Gram-Negative Multidrug-Resistant Phe... by Gaëlle S. Nguenang, Armelle T. Mbaveng, Aimé G. Fankam, Hermione T. Manekeng, Paul Nayim, Brice E. N. Wamba, Victor Kuete

“…Furthermore, extracts of leaf of Tristemma hirtum and pericarps of Raphia hookeri (at their MIC/2 and MIC/4) strongly potentiated the activities of all antibiotics used in the study, especially those of chloramphenicol (CHL), ciprofloxacin (CIP), kanamycin (KAN), and tetracycline (TET) against 70% (7/10) to 100% (10/10) of the tested MDR bacteria, with the modulating factors ranging from 2 to 128. …”
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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. by Kelly Lim, Winnie L Kan, Pramod C Nair, Monika Kutyna, Angel F Lopez, Timothy Hercus, David M Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

“…Interestingly, 64% of patients presented with more than one CBL variant implying a complex subclonal architecture, often with co-occurrence of TET2 mutations. We found CBL mutations in CMML frequently clustered in the RING domain in contrast to JMML, where mutations frequently involve the linker helix region (P<0.0001). …”
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β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia by Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, Birgitte Holst, Thue W. Schwartz

“…Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter to selectively overexpress GPR39 in the β cells in a double transgenic mouse strain and challenge them with multiple low doses of streptozotocin, which in the wild-type littermates leads to a gradual increase in nonfasting glucose levels and glucose intolerance observed during both food intake and OGTT. …”
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EBV-Negative Monomorphic B-Cell Posttransplant Lymphoproliferative Disorder with Marked Morphologic Pleomorphism and Pathogenic Mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53 by Agata M. Bogusz

“…Next-generation sequencing studies (NGS) revealed numerous genetic alterations including 6 pathogenic mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53(x2) genes and 30 variants of unknown significance (VOUS) in ABL1, ASXL1, ATM, BCOR, BCORL1, BRNIP3, CDH2, CDKN2A, DNMT3A, ETV6, EZH2, FBXW7, KIT, NF1, RUNX1, SETPB1, SF1, SMC1A, STAG2, TET2, TP53, and U2AF2.…”
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Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation by Dylan J. Sebo, Irshad Ali, Audrey R. Fetsko, Aubrey A. Trimbach, Michael R. Taylor

“…To further test this concept, we generated a transgenic Tet-On inducible system to drive constitutively active β-catenin expression in neural progenitor cells (NPCs). …”
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Root exudates regulate soil antibiotic resistance genes via rhizosphere microbes under long-term fertilization by Xiujing Guan, Yuhui Li, Yanying Yang, Zihua Liu, Rongguang Shi, Yan Xu

“…The metabolome analysis evidenced that significant correlations were found between defensive root exudates and most ARGs abundance (p < 0.05), like, luteolin-7-glucoside was negatively correlated with tetA(58). These findings provide deeper insights into the dynamics of soil ARGs under long-term fertilization, and identify critical factors that influence ARGs colonization in soils, providing support for controlling the spread of ARGs in agriculture soils.…”
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Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic by Christian Diamant Mossoro-Kpinde, Alexandre Manirakiza, Jean-Robert Mbecko, Pembé Misatou, Alain Le Faou, Thierry Frank

“…Nine resistance-associated genes, blaTEM, blaOXA, blaSHV, tetA, aadA1, catA1, dhfrA1, sul I, and sul II, were sought by genic amplification in seven S.e. …”
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Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway by Lei Huang, Zhaoyun Liu, Hui Liu, Kai Ding, Fu Mi, Chenhuan Xiang, Guanrou Wang, Yixuan Guo, Rong Fu

“…The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS. …”
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CHIP away at the marrow-clot connection: inflammation, clonal hematopoiesis, and thromboembolic disease by Angela Todorovski, Tzu-Fei Wang, Marc Carrier, Yan Xu

“…However, canakinumab showed promise in a post-hoc analyses of patients with TET2-mutated CHIP, and other anti-inflammasome agents are actively under development or evaluation. …”
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Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes by Paul Nayim, Armelle T. Mbaveng, Brice E. N. Wamba, Aimé G. Fankam, Joachim K. Dzotam, Victor Kuete

“…Some tested extracts included extracts from the leaves of T. cacao and P. vulgaris, and the seeds of D. edulis and barks A. indica has selectively improved (2- to 64-fold) the antibacterial activities of some of the tested antibiotics, chloramphenicol (CHL), tetracycline (TET), kanamycin (KAN), streptomycin (STR), and erythromycin (ERY), against more than 70% of tested MDR bacteria. …”
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Prevalence and antibiotic resistance of Escherichia coli in urban and peri-urban garden ecosystems in Bangladesh. by Pritom Kumar Pramanik, M Nazmul Hoque, Md Liton Rana, Md Saiful Islam, Md Ashek Ullah, Fahim Haque Neloy, Srinivasan Ramasamy, Pepijn Schreinemachers, Ricardo Oliva, Md Tanvir Rahman

“…The blaTEM gene was present in 81.48% of the isolates, while the tetA gene was detected in 3.70%. These findings underscore the urgent global health concern posed by the significant presence of E. coli in fresh vegetables, highlighting the need for improved safety measures and monitoring to prevent the spread of antimicrobial resistance through the food chain.…”
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Priestia flexa as a Novel Urinary Tract Pathogen in Daloa, Côte d’Ivoire: Insights From Genomic Sequencing by Dého Aristide Gbégbé, Okran Beyosse Christophe Kacou, N’goran Parfait N’zi, Djédoux Maxime Angaman

“…Two plasmids were predicted in the genomes of isolates 21LM367 and 21LM1136; however, rep7a and IncI2 were predicted to contain the tet(K) resistance gene. No typical multilocus sequences could be characterised in the genomes of the different strains.…”
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Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice by Tingting Cao, Yajie Guo, Liangqiang Lin, Dan Wang, Zhiyang Liu, Xuan Zou, Yuebin Ke, Ziquan Lv

“…Compared with the control group, the abundance of APH6-Ic and AAC6-Ie-APH2-Ia resistance genes in mice treated with folpet significantly increased. The abundance of tetQ, ermE, and BahA resistance genes was significantly reduced after folpet treatment. …”
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Risk assessment and photo-disinfection of antibiotic residues and antibiotic-resistant bacteria in water sources from Ede, Nigeria by Gloria O. Taylor, Aemere Ogunlaja, Olumide D. Olukanni, Oluwatosin M. Awopetu, Frances Okodua, Daniel O. Godson, Afolarin Otusile, Daniella Ekpe, Esther Deguenon, Kevin M. Sintondji, Victorien Dougnon, Olumuyiwa O. Ogunlaja, Chidinma G. Olorunnisola, Martins O. Omorogie, Moses O. Alfred, Emmanuel I. Unuabonah

“…Antibiotic residues detected included tetracycline-TET (14.2–135.8 μg/L), chloramphenicol-CHL (6.8–224.7 μg/L), metronidazole-MET (3.7–83.8 μg/L), sulfamethoxazole-SUL (0.56–18.6 μg/L), and ciprofloxacin-CIP (3.8–97 μg/L). …”
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野生动物笼舍环境中大肠埃希氏菌对抗生素和消毒剂的抗性分析 by 刘青, 郭玲, 仉伟, 赵国策, 朱云芸, 尹占龙, 谢绪昌

“…抗性基因共检测到<italic>mdfA</italic>、<italic>tet</italic>（<italic>A</italic>）、<italic>qnrS</italic>、<italic>dfrA</italic>、<italic>bla</italic>_TEM、<italic>sugE</italic>、<italic>emrE</italic>、<italic>qacE</italic>和<italic>qacH</italic>等29种。…”
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High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens by Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus, Koleka P. Mlisana

“…Concordance between molecular detection (real-time PCR and HRM) and resistance phenotype was ≥92% for blaTEM (HLR penicillin), rpsJ_V57M (tetracycline), tetM (tetracycline), and gyrA_S91F (ciprofloxacin). …”
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