Clinical outcome of non-alcoholic fatty liver disease: an 11-year follow-up study by Steven Dooley, Juan Du, Xiaoping Tang, Lan Chen, Jinzhu Jia, Fujun Li, Yanyan Shi, Christoph Meyer, Zhongwei Zhu, Yanming Zhang, Roman Liebe, Keming Hu, Tingting Zhou, Huier Zhang, Hong-Lei Weng, Tong Huang

Get full text

Rationale and design for Healthy Hearts in Manufacturing (HHM): A pragmatic single-arm hybrid effectiveness-implementation study for hypertension management and tobacco cessation by Hanzi Jiang, Yao Tian, Jennifer Bannon, Amy E. Krefman, Lawrence C. An, Dustin D. French, Claude R. Maechling, Jane Holl, Richard Chagnon, Theresa L. Walunas, Christopher Burch, Anthony Musci, Darce Latsis, Dawn Carey, Megan McHugh

Get full text

The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

Get full text

Multiple and complex eye injuries in children by G.Sh. Arzhimatova, O.V. Karaseva, E.A. Koroleva, G.M. Chernakova

“…Botkin City Clinical Hospital, Moscow, Russian Federation </p> <p> ³Research Institute for Children's Emergency Surgery and Trauma, Moscow, </p> <p> Russian Federation </p> <p> <b>Aim: </b>to identify the medical and epidemiological hallmarks of eye damage in children with complex and multiple injuries in a specialized surgical department. …”
Get full text

Profiling of Somatic Mutations in Phaeochromocytoma and Paraganglioma by Targeted Next Generation Sequencing Analysis by Andrea Luchetti, Diana Walsh, Fay Rodger, Graeme Clark, Tom Martin, Richard Irving, Mario Sanna, Masahiro Yao, Mercedes Robledo, Hartmut P. H. Neumann, Emma R. Woodward, Farida Latif, Stephen Abbs, Howard Martin, Eamonn R. Maher

Get full text

Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…In the past history patient underwent surgery for chronic left-side achillobursitis. In postoperative period antibacterial treatment was prescribed that included first-generation cephalosporin. …”
Get full text

Intermediate risk prostate tumors contain lethal subtypes by William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, John M. Ryniawec, Gregory C. Rogers, Gregory C. Rogers, Noel A. Warfel, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress, Anne E. Cress

“…According to the National Comprehensive Cancer Network (NCCN) treatment guidelines, most cases (65%) are intermediate risk (Gleason sum score &lt;7 [3 + 4, 4 + 3], prostate organ-confined, and PSA &lt; 20) with treatment options limited to active surveillance, external beam radiation, and/or surgery to prevent metastasis in the long term (&gt;10 years). …”
Get full text

Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur by Xue Zheng, Yuhua Luo, Rui Huo, Yiwen Wang, Youbang Chen, Mianrong Chen, Qi Zhao, Kexin Li, Hanyi Zhang, Xiaotong Li, Xiang Li, Hui Zhang, Zaopeng He, Li Huang, Chun-tao Yang

Get full text

Unlocking the potential of serious games for rehabilitation in low and middle-income countries: addressing potential and current limitations by Diriba Dereje, Diriba Dereje, Dheeraj Lamba, Teklu Gemechu Abessa, Teklu Gemechu Abessa, Chala Kenea, Chala Kenea, Cintia Ramari, Cintia Ramari, Muhammad Osama, Muhammad Osama, Oyéné Kossi, Oyéné Kossi, Paul Muteb Boma, Paul Muteb Boma, Jules Panda, Jules Panda, Jules Panda, Anna Kushnir, Anna Kushnir, Joanna Mourad, Joanna Mourad, Jean Mapinduzi, Jean Mapinduzi, Maryam Fourtassi, Kim Daniels, Kim Daniels, Judith Deutsch, Bruno Bonnechère, Bruno Bonnechère, Bruno Bonnechère

Get full text

Refraction in adolescents with various severity of Internet addiction and intensity of device use by T.R. Mukhamadeev, R.R. Akhmadeev, E.F. Shaykhutdinova, A.R. Khusniyarova

“…Khusniyarova¹ </p> <p> ¹Bashkir State Medical University, Ufa, Russian Federation </p> <p> ²All-Russian Center for Eye and Plastic Surgery of the Bashkir State Medical University, Ufa, Russian Federation </p> <p> ³CJSC "Optimedservis", Ufa, Russian Federation </p> <p> <b>Aim:</b> to assess refraction in adolescent Internet users with various severity of Internet addiction and intensity of device use. …”
Get full text

Prevention Of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) trial: protocol for a randomised controlled trial by Robert Clarke, Emma J Crosbie, Basil G Issa, John Belcher, Helen Clarke, Anthony Howell, Michelle Harvie, Hannah Harrison, Cheryl Lombardelli, Suzanne Krizak, Katharine Sellers, Yit Y Lim, Caroline Parkin, Shruthi Patel, Anthony J Maxwell, Julie Wisely, Sacha J Howell

“…Introduction Obesity and overweight are strong potentially modifiable risk factors for postmenopausal breast and endometrial cancer. Bariatric surgery can achieve considerable weight loss and risk reduction of weight-related cancer but is unlikely to be a feasible cancer prevention strategy. …”
Get full text

TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets by John Quan Nguyen, Avery Goss, Helen Keshishian, Francis Berchard, Jonathan Parks, Conor Evans

Get full text

Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis by Zhencheng Xiong, Ping Yi, Jialiang Lin, Shengfeng Qiu, Li Shu, Chi Zhang

Get full text

The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

Get full text

Conjunctival component of computer vision syndrome — causes and mechanisms of subjective manifestations by R.R. Akhmadeev, T.R. Mukhamadeev, E.F. Shaykhutdinova, A.R. Khusniyarova

“…Khusniyarova⁴ </p> <p> ¹Bashkir State Medical University, Ufa, Russian Federation </p> <p> ²All-Russian Center for Eye and Plastic Surgery of the Bashkir State Medical University, Ufa, Russian Federation </p> <p> ³CJSC "Optimedservis", Ufa, Russian Federation </p> <p> ⁴Karmaskaly Central Regional Hospital, Karmaskaly, Russian Federation </p> <p> <b>Aim</b>: to evaluate the frequency and severity of subjective conjunctival signs of computer vision syndrome (CVS) and to discuss their possible causes and mechanisms. …”
Get full text

Somatic copy number deletion of chromosome 22q in papillary thyroid carcinoma by Olivia W Lee, Danielle M Karyadi, Stephen W Hartley, Weyin Zhou, Mitchell J Machiela, Shahriar A Zamani, Liudmyla Yu Zurnadzhy, John N Weinstein, Young Joo Park, Jeong-Sun Seo, Gerry A Thomas, Tetiana I Bogdanova, Mykola D Tronko, Lindsay M Morton, Stephen J Chanock

Get full text

Albumin corrected anion gap and clinical outcomes in elderly patients with acute kidney injury caused or accompanied by sepsis: a MIMIC-IV retrospective study by Yongbin Wang, Lei Zhong, Jie Min, Jianhong Lu, Jinyu Zhang, Jiajun Su

Get full text

Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…JiangFei Zhou,1,&ast; SongSong Jiao,1,&ast; Jian Huang,2,&ast; TianMing Dai,3,&ast; YangYang Xu,1,&ast; Dong Xia,4,&ast; ZhenCheng Feng,1 JunJie Chen,1 ZhiWu Li,5 LiQiong Hu,4 QingQi Meng1,3 1Department of Orthopedics, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 4Critical Care Medicine Department, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 5Department of Orthopedics, the 2nd People’s Hospital of Bijie, Guizhou, 551700, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: LiQiong Hu; QingQi Meng, Email 13929526981@163.com; mengqingqi@jnu.edu.cnBackground: Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. …”
Get full text

Clinical Study of Sentinel Lymph Node Detection to Evaluate Pelvic Lymph Node Metastasis to Determine the Prognosis of Patients with Early Cervical Cancer by Peipei Li, Shuai Feng, Guodong Zhou, Lu Zhang, Xiugui Sheng, Dapeng Li

“…Methylthioninium chloride was injected in combination with 99mtechnetium-labeled sulfur colloid prior to surgery to these patients. SLNs were identified intraoperatively, excised, and subsequently submitted to fast frozen section. …”
Get full text

Combination Treatment with Thread-Embedding Acupuncture and Electroacupuncture for Knee Osteoarthritis Patients with Postoperative Pain: A Randomized Controlled Feasibility Study by Lee YJ, Han CH, Jeon JH, Kim E, Park KH, Kim AR, Kim YI

“…Ye Ji Lee,1,&ast; Chang-Hyun Han,2,3,&ast; Ju Hyun Jeon,1 Eunseok Kim,4,5 Ki Hyun Park,6 Ae Ran Kim,7 Young Il Kim1 1Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea; 2KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 3Korean Convergence Medicine, University of Science and Technology (UST), Campus of Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 4Department of Acupuncture and Moxibustion Medicine, Pusan National University Korean Medicine Hospital, Yangsan, Republic of Korea; 5Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea; 6KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 7Clinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea&ast;These authors contributed equally to this workCorrespondence: Young Il Kim, Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea, Email omdkim01@dju.krPurpose: This study aimed to evaluate the effectiveness and safety of combination treatment with thread-embedding acupuncture (TEA) and electroacupuncture (EA) in patients with persistent knee pain after arthroscopic surgery, autologous chondrocyte implantation, or autologous osteochondral transplantation.Patients and Methods: Twelve patients with knee osteoarthritis (KOA) who experienced postoperative pain were randomized to either the treatment group (TG) or control group (CG) in a 1:1 ratio. …”
Get full text