Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study by Li-Qiong Chen, Yong-Can Zhou, Fang Ning, Ming-Jin Zhu

“…The model group received normal saline, the western medicine group received lorazepam suspension, and the Chinese medicine group received Jiawei Suanzaoren decoction. The sham surgery group was given routine feeding. The sleep condition, the levels of blood hormone levels and the expression levels of 5-Hydroxytryptamine (5-HT) and Gamma-Aminobutyric Acid receptor A (GABAA) receptor in the hypothalamus were compared between groups.ResultsIn clinical observation, the sleep condition and the changes of hormone levels between the treatment group and the control group were statistically significant (P < 0.05). …”
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Impact of hearing loss and vestibular decline on cognition in Alzheimer’s disease: a prospective longitudinal study protocol (Gehoor, Evenwicht en Cognitie, GECkO) by Patrick Cras, Vincent Van Rompaey, Joyce Bosmans, Cathérine Jorissen, Angelique Van Ombergen, Sebastiaan Engelborghs, Annick Gilles, Eline Princen, Julie Moyaert, Griet Mertens

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Post-craniotomy infections: A point-by-point approach by Giovanni Carone, Marta Bonada, Evelyn Gisell Belotti, Eugenia D'Angeli, Annica Piccardi, Fabio Martino Doniselli, Guido Gubertini, Cecilia Casali, Francesco DiMeco, Massimiliano Del Bene

“…Significant risk factors identified include CSF leakage, emergency surgery, and certain tumour types, with infections typically manifesting post-discharge. …”
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The Effect of Blood-Derived Products on the Chondrogenic and Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Originated from Three Different Location... by Markus Neubauer, Olga Kuten, Christoph Stotter, Karina Kramer, Andrea De Luna, Thomas Muellner, Zsombor Lacza, Stefan Nehrer

“…Adipose-derived mesenchymal stem cells (AD-MSCs) from fat tissue considered “surgical waste” during joint surgery may provide a potent source for regenerative medicine. …”
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The cardiac function characteristics and nursing measures of endoscopic endonasal transsphenoidal approach for growth hormone-secreting pituitary adenoma complicated with cardiomyo... by YAN Ying (闫莹), HE Xin (贺欣)

“…Methods The clinical data of 38 cases of patients who underwent endoscopic endonasal transsphenoidal approach for the treatment of growth hormone-secreting pituitary adenoma complicated with cardiomyopathy were collected and analyzed, Using echocardiography to detect the growth hormone(GH) level, left ventricular end-diastolic diameter(LVEDD), septal thickness(ST), left ventricular posterior wall thickness(LVPWT), left ventricular ejection fraction(LVEF) to comparative analysis of cardiac function were made in these patients before surgery and after 3 months. Results GH level, LVIDD, ST, LVPWT and LVEF after resection of pituitary tumor were significantly improved compared with those before resection(P<0. 05). …”
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Incidence and Clinical Outcomes of Hip Fractures Involving Both the Subcapital Area and the Trochanteric or Subtrochanteric Area by Takayuki Tani, Hiroaki Kijima, Natsuo Konishi, Hitoshi Kubota, Shin Yamada, Hiroshi Tazawa, Norio Suzuki, Keiji Kamo, Yoshihiko Okudera, Masashi Fujii, Ken Sasaki, Tetsuya Kawano, Yosuke Iwamoto, Itsuki Nagahata, Naohisa Miyakoshi, Yoichi Shimada

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A Case Study Identified a New Mutation in the TTN Gene for Inherited Hypertrophic Cardiomyopathy by Dong J, Liu M, Chen Q, Zha L

“…Jiangtao Dong,1– 4,&ast; Meilin Liu,1– 3,&ast; Qianwen Chen,1– 3,5 Lingfeng Zha1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 3Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 4Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 5Department of Pediatric Cardiology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lingfeng Zha, Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, People’s Republic of China, Tel +86-15827177185, Email zhalf@hust.edu.cnBackground: Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy, with variable pathogenesis, clinical presentation, and prognosis. …”
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Association among high blood pressure health literacy, social support and health-related quality of life among a community population with hypertension: a community-based cross-sec... by Ting Chen, Wei Gan, Li Song, Yujie Wang, Huan Qi, Qinghua Zhang, Jinyu Yin

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Influencing factors of acute kidney injury in elderly patients with diabetic nephropathy and establishment of nomogram model by Ganlin Wu, Ganlin Wu, Yanli Ye, Meirong Xu, Yanxia Zhang, Zuopeng Lu, Lv Huang

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Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain by Christian Kirschneck, Erika Calvano Küchler, Michael Wolf, Gerrit Spanier, Peter Proff, Agnes Schröder

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Prediction model, risk factor score and ventilator-associated pneumonia: A two-stage case-control study by Hua Meng, Yuxin Shi, Kaming Xue, Di Liu, Xiongjing Cao, Yanyan Wu, Yunzhou Fan, Fang Gao, Ming Zhu, Lijuan Xiong

“…Results: LASSO, RF and XGBoost consistently revealed significant associations of length of stay before MV, MV time, surgery, tracheotomy, multiple drug resistant organism infection, C-reactive protein, PaO2, and APACHE II score with VAP. …”
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Savolitinib Induced Pathological Complete Response in Non-small Cell Lung Cancer with MET Amplification: A Case Report by Meng LU, Ran ZHANG, Baiwei LI, Haidi XU, Yongkuan GUO, Jian YOU, Bingsheng SUN

“…This report describes a case of a locally advanced NSCLC patient with dual driver gene mutations (EGFR L858R combined with primary METamp), the tumor did not shrink after 1 month of Gefitinib monotherapy, but significantly subsided after 4 months of Savolitinib monotherapy. After radical surgery, the pathological results proved pathological complete response (pCR) of the tumor, and the patient had a good response to postoperative continual Savolitinib treatment, with no recurrence nor metastasis observed to date. …”
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Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer by Akshara Singareeka Raghavendra, Nicole M. Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S. Gombos, Kelly K. Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

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Can screening for degenerative cervical myelopathy (SCREEN-DCM) be effectively undertaken based on signs, symptoms and known risk factors? Rationale and research protocol for a pro... by Benjamin Davies, Mark Kotter, Granit Molliqaj, Enrico Tessitore, Karl Schaller, Teresa Somma, Aria Nouri, Renato Gondar, Joseph S Cheng, Paolo Cappabianca, Alexandre Lavé, Gianpaolo Jannelli, Allan Martin, Justin Virojanapa, Carmen L A Vleggeert-Lankamp, Valerie ter Wengel, Torstein Meling

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Prospects of two-port vitrectomy in the treatment of patients with epiretinal fibrosis by D.V. Borisova, I.A. Frolychev, N.A. Pozdeeva

“…The maximum functional effect — a decrease in metamorphopsia expression and an increase in best-corrected visual acuity by 0.48±0.1 vs. that at the baseline was observed 3 months after the surgery. </p> <p> <b>Conclusion</b>: in addition to the classical three-port vitrectomy with xenon focal illuminator, it is possible to use the two-port vitrectomy with a mercury vapor chandelier illuminator. …”
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Efforts to strengthen anatomic pathology diagnostic services for cancer in sub-Saharan Africa: a scoping review protocol by Katherine Van Loon, Elia John Mmbaga, Marcia Edelweiss, Dianna L. Ng, Asteria Herman Kimambo, Edda Vuhahula, Beatrice Paul Mushi, Omolade Adegoke, Johanna Goldberg, Pendo M. Ibrahim, Zainab Illonga, Julia Jackman, Luisa Jamisse

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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

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Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

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Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance by Sirui Xu, Chuanyao Dong, Xiaolin Yu, Tianshu Lv, Dapeng Zeng, Ruiyan Li, Xingfu Bao, Kan Zhang

“…In fracture fixation surgery, an ideal bone nail implant should initially provide stable support for the fractured bone and subsequently promote callus formation and bone remodeling. …”
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Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis by Xinyan Hao, Yucheng Tang, Wenjie Xu, Ming Wang, Jiayi Liu, Yongjiang Li, Jun He, Yanjin Peng, Pengcheng Sun, Dehua Liao, Xiongbin Hu, Tiantian Tang, Min Zhou, Ruyue Han, Jiemin Wang, João Conde, Daxiong Xiang, Junyong Wu

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