Construction of a Macrophage-Tropic Subtype C HIV-1-mGreenLantern Reporter Virus for Studies on HIV-1 Replication and the Impact of Methamphetamine by Dina Mofed, Angelo Mandarino, Xuhong Wu, Yuekun Lang, Anjali Gowripalan, Ganjam V. Kalpana, Vinayaka R. Prasad

Subjects: Get full text

Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil by Joao Leandro Paula Ferreira, Rosangela Rodrigues, Andre Minhoto Lança, Valeria Correia de Almeida, Simone Queiroz Rocha, Taisa Grotta Ragazzo, Denise Lotufo Estevam, Luis Fernando de Macedo Brigido

“…HIV-1 B was the prevalent subtype (80%); other subtypes include HIV-1 F and C, mosaics BC, BF, and single cases of subtype A1 and CRF02_AG. …”
Get full text

Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…HIV-negative KS samples displayed the IE and IE/F TME subtypes, while HIV-positive samples exhibited IE, IE/F, and F subtypes. …”
Get full text

Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…Sub-Saharan Africa accounts for almost 70 % of people living with HIV (PLWH) worldwide, with the greatest numbers centred in South Africa where 98 % of infections are caused by subtype C (HIV-1C). However, HIV-1 subtype B (HIV-1B), prevalent in Europe and North America, has been the focus of most cure research and testing despite making up only 12 % of HIV-1 infections globally. …”
Get full text

Barriers to timely diagnosis and management of breast cancer in Africa: Implications for improved outcomes by Roland Muyisa, Emile Watumwa, Judith Malembe, Jacques Wahangire, Ghyslaine Kalivanda, Apollinaire Saa Sita, Soly Kamwira

“…Poor outcomes are often linked to advanced disease stages and larger tumor sizes, along with factors like the luminal B subtype and HIV status. Strategies to improve outcomes should focus on raising awareness, enhancing knowledge of hormonal tumor status, and implementing expedited referral pathways for women with concerning symptoms.Urgent measures for early detection and management are essential to address the breast cancer burden in Africa and improve patient outcomes.…”
Get full text

Tracing the Dispersal Pathway of HIV-1 Subtype C to Bahia: Phylogenetic Connections to Southern Brazil by Daniel Polita, Laise de Moraes, Marta Giovanetti, Filipe Ferreira de Almeida Rego, Luciane Amorim Santos, Dennis Maletich Junqueira, Ricardo Khouri

“…The HIV-1 epidemic in Brazil is predominantly characterized by subtype B, except in the southern states, where subtype C (HIV-1C) is more prevalent. Continuous monitoring of this profile is essential to maintain an accurate understanding of the molecular landscape of the HIV epidemic in Brazil. …”
Get full text

Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort by Ling Yue, Rui Xu, Samantha Mclnally, Qianhong Qin, Jake W. Rhodes, Erick Muok, Gisele Umviligihozo, Kelsie Brooks, Jiayi Zhang, Zhaohui Qin, Jean Bizimana, Jonathan Hare, Matthew A. Price, Susan A. Allen, Etienne Karita, Eric Hunter

“…This panel of well-characterized, authentic subtype A and AC recombinant IMCs provides a resource for studies on the role of the virus subtype in HIV-1 transmission, pathogenesis, and vaccine design.…”
Get full text