Complex Study of Settlements Dating from the Paleolithic to Medieval Period in the Ural Mountains on the Border of Europe and Asia by Valentina Prikhodko, Nikita Savelev, Vyacheslav Kotov, Sergey Nikolaev, Evgeny Ruslanov, Mikhail Rumyantsev, Elena Manakhova

“…Cultural layers (<b>CLs</b>) are marked by finds of ceramics fragments, animal bones, stone, and metal tools. The properties of CLs include close-to-neutral pH, being well structured, the absence of salinity, enrichment with exchangeable calcium, and anthropogenic phosphorus (0.2–0.4%). …”
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Le port antique de Chelles (Seine-et-Marne) : une course après la rivière by Yann Le Jeune, Corinne Charamond, Christian Charamond

“…-Phase 4, around 70 AD: a much smaller structure, formed of two parallel stone walls associated with wooden posts, was established at the western border of the port area and more than 7 m from the original ancient riverbank. …”
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The effect of green management on sustainable marketing orientation in small and medium industrial businesses: the mediating role of social legitimacy by Heshmatollah Soroushnia, Jalal Haghighatmonfared, Anahita Salari

“…The new CVPAT index, instead of the Stone-Geisser Q2 index (>0.0), has been used. The new HTMT index also evaluates the divergent validity of the structural model. …”
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Editorial by Teddy Surya Gunawan

“…Let us embrace these breakthroughs as stepping stones to a brighter, more sustainable future.   …”
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Diseño tecnológico de un lugar de culto: valor histórico y constructivo = Technological design of a worship place: historical and constructive value by Antonella Violano, Antonio Maio

“…This is especially true for Christian places of worship, where every stone, spatial distribution, and ornament carries a deep symbolic, moral, and social meaning. …”
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Diagnostic value of the MZXBTCH scoring system for acute complex appendicitis by Tianyi Ma, Qian Zhang, Hongwei Zhao, Peng Zhang

“…Multivariate logistic regression analysis identified preoperative body temperature (odds ratio (OR) = 1.104; 95% confidence interval (CI) 1.067–1.143; P < 0.001), preoperative C-reactive protein (CRP) level (OR = 1.002; 95% CI 1.001–1.002; P < 0.001), lymphocyte percentage (OR = 0.994; 95% CI 0.990–0.996; P < 0.001), appendiceal fecal stones (OR = 1.127; 95% CI 1.068–1.190; P < 0.001), periappendiceal fat stranding (OR = 1.133; 95% CI 1.072–1.198; P < 0.001), and appendix diameter (OR = 1.013; 95% CI 1.004–1.022; P < 0.001) as independent risk factors for complex appendicitis. …”
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S’approprier, c’est résister. Appropriations spatiales et mobilisation infra-politique des femmes en immobilité résidentielle et sociale dans les bidonvilles de Salé (Maroc)... by Myriame Ali-Oualla

“…A relatively loose regime of urban regulation allowed sporadic settlement by small groups from the same districts, often from the same villages, creating communities that shared cultural references, ways of living, migratory routes and spatialised collective memory – attributes necessary for anchoring a new identity.Thanks to the evolving ambitions of the new arrivals, the shantytown has become a stepping stone to urban living, and one of the most viable housing alternatives, permitting easy and cheap access to urban amenities. …”
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Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia by Marlise R. Luskin, Shai Shimony, Julia Keating, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Elias Jabbour, Yael Flamand, Kristen Stevenson, Jeremy Ryan, Zhihong Zeng, Anthony Letai, Marina Konopleva, Nitin Jain, Daniel J. DeAngelo

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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-... by Caroline J. Stone, Geeta Ahuja, Lais Lopes Almeida Gomes, Joy Poroye, Daniella Forman Faden, Lillian Xie, Rui Feng, Barbara White, Victoria P. Werth

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Evaluation of variation in special educational needs provision and its impact on health and education using administrative records for England: umbrella protocol for a mixed-method... by Stuart Logan, Ruth Gilbert, Tamsin Ford, Johnny Downs, Jugnoo Rahi, Ania Zylbersztejn, Katie Harron, Kate Boddy, Bianca De Stavola, Vincent Nguyen, Isaac Winterburn, Kate Lewis, Lucy Karwatowska, Lorraine Dearden, Sarah Barnes, Jacob Matthews, Matthew Lilliman, Jennifer Saxton, Antony Stone, Kristine Black-Hawkins

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Syphilis reactivity among blood donors in Brazil: associated factors and implications for public health monitoring by Natalia A. Braga, Sheila de Oliveira Garcia Mateos, Renata Buccheri, Vivian I. Avelino-Silva, Donald E. Warden, Cesar de Almeida-Neto, Maisa Ribeiro, Luiz Amorim, Paula Loureiro, Nelson Fraiji, Marcio K. Oikawa, Eduard Grebe, Mars Stone, Ester C. Sabino, Brian Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)

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Construction of “Biomigration – Regional Cooling” Multi-functional Ecological Network in Wuhan Urban Agglomeration by Jiajie LI, Yuanyuan GU, Zhong XING

“…To address this, ecological networks composed of source sites, corridors, and stepping-stone patches are proposed to restore landscape connectivity and integrity, thereby ensuring ecological security. …”
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Les réseaux d’alimentation en eau des pentes de la Croix-Rousse et de la presqu’île de Lyon by Jules Ramona

“…They are quite similar, generally circular and lined with local stones, with a diameter of between 0.60 and 1.20 m. …”
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Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats by Axelle Amen, Randy Yoo, Amanda Fabra-García, Judith Bolscher, William JR Stone, Isabelle Bally, Sebastián Dergan-Dylon, Iga Kucharska, Roos M de Jong, Marloes de Bruijni, Teun Bousema, C Richter King, Randall S MacGill, Robert W Sauerwein, Jean-Philippe Julien, Pascal Poignard, Matthijs M Jore

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Supervised Injecting Room Cohort Study (SIRX): study protocol by Lisa Maher, Thomas Kerr, Matthew Hickman, Alexander Thompson, Peter Higgs, Paul Dietze, Paul A Agius, Nick Scott, Daniel O’Keefe, Mark A Stoové, Jack Stone, Dylan Vella-Horne, Ashleigh C Stewart, Amanda Roxburgh, Sione Crawford, Josephine Norman, Zachary Lloyd, Nico Clark

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Aides à la navigation, pratique de la navigation et construction des paysages maritimes en Atlantique du Nord-Est : quelques éléments de réflexion by Pascal Arnaud

“…A variety of solutions existed: stone-built benchmarks at harbour entrances, aligned daymarks to indicate the navigation channel, marking of the channel with piles or floats. …”
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L’aqueduc du Gier : nouvelles données sur le pont-siphon de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by David Baldassari, François Blondel, Stéphane Gaillot

“…One type was oolitic Bathonian limestone from Beaujolais (Lucenay stone), the outcrops of which are located in the Beaujolais hills on the right bank of the Saône, about 20 km as the crow flies north of the site. …”
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The Great Lakes Winter Grab: Limnological data from a multi‐institutional winter sampling campaign on the Laurentian Great Lakes by Ge Pu, Kirill Shchapov, Nolan J. T. Pearce, Kelly Bowen, Andrew Bramburger, Andrew Camilleri, Hunter Carrick, Justin D. Chaffin, William Cody, Maureen L. Coleman, Warren J. S. Currie, David C. Depew, Jonathan P. Doubek, Rachel Eveleth, Mark Fitzpatrick, Paul W. Glyshaw, Casey M. Godwin, R. Michael McKay, Mohiuddin Munawar, Heather Niblock, Maci Quintanilla, Michael Rennie, Matthew W. Sand, Kimberly J. Schraitle, Michael R. Twiss, Donald G. Uzarski, Henry A. Vanderploeg, Trista J. Vick‐Majors, Judy A. Westrick, Bridget A. Wheelock, Marguerite A. Xenopoulos, Arthur Zastepa, Ted Ozersky

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WUJUD ARSITEKTUR RUMAH TRADISIONAL DI DELTA LAKKANG KOTA MAKASSAR by Marwati Marwati, A. Eka Oktawati

“…The shape of the structure and the material was the foundation of a stone base, the connection of wood and roof material is zinc. …”
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