High levels of histone acetylation modifications promote the formation of PGCs by Ziduo Zhao, Yuhui Wu, Fufu Cheng, Zhe Wang, Qingqing Geng, Yingjie Niu, Qisheng Zuo, Yani Zhang

“…This study investigates the role of histone acetylation in the differentiation of chicken embryonic stem cells (ESCs) into primordial germ cells (PGCs). …”
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Intensified conditioning containing decitabine versus standard myeloablative conditioning for adult patients with KMT2A-rearranged leukemia: a multicenter retrospective study by Zhongli Hu, Zinan Feng, Shiqi Liu, Hai He, Ying Dong, Zhiping Fan, Yiqing Li, Fen Huang, Na Xu, Can Liu, Yunxin Zeng, Ping Zhu, Ren Lin, Hua Jin, Xiong Zhang, Ruijuan Sun, Qifa Liu, Li Xuan

“…Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended for patients with KMT2A-rearranged (KMT2A-r) leukemia whereas relapse remains high. …”
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Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases by Camila Ferreira de Souza, Alice Santana Morais, Miriam Galvonas Jasiulionis

“…At the present time, at least three hypotheses were identified that may explain melanoma aetiology, as follows: (1) a model of linear progression from differentiated melanocytes to metastatic cancer cells (2) a model involving the appearance of melanoma stem-like cells, and (3) an epigenetic progenitor model of cancer. …”
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Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications by Yukihiko Kinoshita, Hatsuhiko Maeda

“…In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Recent developments in the field of tissue engineering have led to a renewed interest in novel biomaterial alternatives such as stem cells. This might be attributable to their differentiation potential towards hepatic and pancreatic lineage. …”
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Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases by Ya-Min Ma, Lan Zhao

“…They can also increase or reduce neuronal damage by regulating the body’s signaling pathways, immune system, stem cells, gut microbiota, etc. They can not only affect the occurrence of diseases and exacerbate disease progression but also promote neuronal repair and reduce apoptosis, to prevent and slow down the development of diseases. …”
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Hypothesis: glyphosate-based herbicides can increase risk of hematopoietic malignancies through extended persistence in bone by Charles M. Benbrook

“…A novel two-part hypothesis is explored: first, the likely reason for the lack of variability in GLY levels in urine is that GLY stored in bone is excreted gradually over days to weeks, and augments the generally stable and modest levels of dietary exposure to GLY; and second, the prolonged systemic movement of GLY into bone marrow and bone extends contact between GLY and hematopoietic stem cells (HSC), increasing the risk of GLY-induced breaks and rearrangements in the DNA in HSCs. …”
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A mathematical model of mechanotransduction by Bradley J. Roth

“…Potential applications are discussed, such as predicting growth and remodeling in the diseased heart, analyzing stretch-induced arrhythmias, modeling shear forces in a vessel caused by blood flow, examining the role of mechanical forces in engineered sheets of tissue, studying differentiation in colonies of stem cells, and characterizing the response to localized forces applied to nanoparticles.…”
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Release of Copper / Magnesium Ions from Hydroxyapatite-Based Fiber Scaffolds Hasten Bone Healing and Regeneration by Adil Elrayah, Jie Weng, Dongqin Xiao, Azher S Barrak

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Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as In Vitro Cytotoxic and Antimicrobial Candidates by Hassan M. Faidallah, Sherif A. F. Rostom, Khalid A. Khan

“…They were evaluated for their in vitro cytotoxic effects against three different human tumor cell lines (human colon carcinoma HT29, hepatocellular carcinoma Hep-G2, and Caucasian breast adenocarcinoma MCF7). …”
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Biomaterials in Guided Bone and Tissue Regenerations: An Update by Reza Abdollahi Namanloo, Maedeh Ommani, Kamyar Abbasi, Mostafa Alam, Ashkan Badkoobeh, Mahdi Rahbar, Hadi Kokabi Arasteh, Emran Hajmohammadi, Reza Sayyad Soufdoost, Seyed Ali Mosaddad

“…Secondly, biomaterials are examined for their therapeutic uses such as growth factors, stem cells, and gene delivery vehicles. Conclusion. …”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…Different types of nanoparticles, such as liposomes, extracellular vehicles, and polymeric nanoparticles, have been studied for their effectiveness in targeting cancer cells. Nanotherapy has also been investigated for overcoming drug resistance, targeting cancer stem cells, bypassing efflux pumps, and gene silencing. …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Stemming from these observations, a worthwhile future goal in the treatment of HER2+ breast cancer is to promote combinatorial approaches that better eradicate HER2+ cancer cells via enhanced immunological mechanisms.…”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…PPAR ligands are endowed with antitumoral effects, mainly acting on cancer stem cells, and constitute a possible add-on therapy to antiblastic drugs, in particular for NB with unfavourable prognosis. …”
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Wound Healing Using Electrical Stimulation: A Review by Farah Jala Jaseem, Jameel Kadhim Abed, Ahmed Rashid Ajel, Noaman Mohammad Noaman

“…The healing of wounds is always attributed to the ability of the affected skin to produce an electric current that helps the migration of stem cells and platelets to the place of extraction For the sake of healing, this is why electrical stimulation ES devices played an important role in the process of stimulation and wound treatment through using the high voltage pulsed current HVPC, low voltage pulsed current LVPC, direct current DC or pulse current PC. …”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…To date, many studies report several determinants of resistance to this aggressive therapy: (1) O6-methylguanine-DNA methyltransferase (MGMT), (2) the complexity of several altered signaling pathways in GBM, (3) the existence of glioma stem-like cells (GSCs), and (4) the blood-brain barrier. …”
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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…A significant increase in the relative Abz activities associated with a specific reorganization of the immune system, including changes in the differentiation and proliferation of bone marrow hematopoietic stem cells and lymphocyte proliferation in different organs. …”
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The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention by A. V. Kononov

“…The activity of gastritis (infiltration of the mucosa with neutrophilic leukocytes) of any etiology is the theoretical justification for the use of bismuth tripotassium dicitrate pharmacological preparation to protect the genome of stem cells of the gastric epithelium as a secondary prevention of gastric cancer.…”
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Rat Sarcoma Virus Family Genes in Acute Myeloid Leukemia: Pathogenetic and Clinical Implications by Shaimaa Khattab, Adriatik Berisha, Natalia Baran, Pier Paolo Piccaluga

“…Acute myeloid leukemias (AMLs) comprise a group of genetically heterogeneous hematological malignancies that result in the abnormal growth of leukemic cells and halt the maturation process of normal hematopoietic stem cells. …”
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Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease by Vittoria Cammisotto, Emanuele Valeriani, Pasquale Pignatelli, Francesco Violi

“…NOX acts both in hepatocytes and in non-parenchymal hepatic cells, contributing to hepatocyte lipotoxicity, impaired hepatic microcirculation, hepatic stellate, and mesenchymal stem cells activation and proliferation. …”
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